PMID- 33801430 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210413 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 9 IP - 3 DP - 2021 Mar 2 TI - Maximum Expiratory Flow of Children and Adolescents Living at Moderate Altitudes: Proposed Reference Values. LID - 10.3390/healthcare9030264 [doi] LID - 264 AB - (1) Background: Spirometry is useful for diagnosing and monitoring many respiratory diseases. The objectives were: (a) compare maximum expiratory flow (MEF) values with those from international studies, (b) determine if MEF should be evaluated by chronological age and/or maturity, (c) develop reference norms for children, and adolescents. (2) Methods: A cross-sectional study was designed with 3900 subjects ages 6.0 and 17.9 years old. Weight, standing height, sitting height, and MEF were measured. Length of the lower limbs, body mass index (BMI), and age of peak height velocity growth (APHV) were calculated. (3) Results: Values for the curves (p50) for females of all ages from Spain and Italy were higher (92 to 382 (L/min)) than those for females from Arequipa (Peru). Curve values for males from Spain and Italy were greater [70 to 125 (L/min)] than the males studied. MEF values were similar to those of Chilean students ages 6 to 11. However, from 12 to 17 years old, values were lower in males (25 to 55 (L/min)) and in females (23.5 to 90 (L/min)). Correlations between chronological age and MEF in males were from (r = 0.68, R(2) = 0.39) and in females from (r = 0.46, R(2) = 0.21). Correlations between maturity (APHV) and MEF for males were from (r = 0.66, R(2) = 0.44) and for females (r = 0.51, R(2) = 0.26). Percentiles were calculated for chronological age and APHV. Conclusion: Differences occurred in MEF when compared with other geographical regions of the world. We determined that maturity may be a more effective indicator for analyzing MEF. Reference values were generated using chronological age and maturity. FAU - Cossio-Bolanos, Marco AU - Cossio-Bolanos M AD - Universidad Catolica del Maule, Avenida San Miguel 3605, 3466706 Talca, Chile. FAU - Vidal-Espinoza, Ruben AU - Vidal-Espinoza R AD - Universidad Catolica Silva Henriquez, Gral. Jofre 462, 8330225 Santiago, Chile. FAU - Castelli Correia de Campos, Luis Felipe AU - Castelli Correia de Campos LF AD - Universidad del Bio Bio, Avda. Collao 1202 Casilla 5-C, 4050231 Chillan, Chile. FAU - Urzua-Alul, Luis AU - Urzua-Alul L AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, 8320000 Santiago, Chile. FAU - Fuentes-Lopez, Jose Damian AU - Fuentes-Lopez JD AD - Instituto de Investigacion en Ciencias de la Educacion (IICE), Universidad Nacional del Altiplano de Puno, 21001 Puno, Peru. FAU - Sulla-Torres, Jose AU - Sulla-Torres J AD - Universidad Nacional de San Agustin de Arequipa, 04000 Arequipa, Peru. FAU - Andruske, Cynthia Lee AU - Andruske CL AD - Centro de Investigacion Especializada CINEMAROS, 04000 Arequipa, Peru. FAU - Gomez-Campos, Rossana AU - Gomez-Campos R AD - Universidad Catolica del Maule, Avenida San Miguel 3605, 3466706 Talca, Chile. LA - eng PT - Journal Article DEP - 20210302 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC7998629 OTO - NOTNLM OT - adolescents OT - altitude OT - children OT - maximum expiratory flow OT - percentiles COIS- The authors declare no conflict of interest. EDAT- 2021/04/04 06:00 MHDA- 2021/04/04 06:01 PMCR- 2021/03/02 CRDT- 2021/04/03 01:08 PHST- 2021/01/25 00:00 [received] PHST- 2021/02/10 00:00 [revised] PHST- 2021/02/22 00:00 [accepted] PHST- 2021/04/03 01:08 [entrez] PHST- 2021/04/04 06:00 [pubmed] PHST- 2021/04/04 06:01 [medline] PHST- 2021/03/02 00:00 [pmc-release] AID - healthcare9030264 [pii] AID - healthcare-09-00264 [pii] AID - 10.3390/healthcare9030264 [doi] PST - epublish SO - Healthcare (Basel). 2021 Mar 2;9(3):264. doi: 10.3390/healthcare9030264.