PMID- 33802116 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210413 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 11 IP - 3 DP - 2021 Mar 10 TI - Is Lateropulsion Really Related with a Specific Lesion of the Brain? LID - 10.3390/brainsci11030354 [doi] LID - 354 AB - Lateropulsion (pusher syndrome) is an important barrier to standing and gait after stroke. Although several studies have attempted to elucidate the relationship between brain lesions and lateropulsion, the effects of specific brain lesions on the development of lateropulsion remain unclear. Thus, the present study investigated the effects of stroke lesion location and size on lateropulsion in right hemisphere stroke patients. The present retrospective cross-sectional observational study assessed 50 right hemisphere stroke patients. Lateropulsion was diagnosed and evaluated using the Scale for Contraversive Pushing (SCP). Voxel-based lesion symptom mapping (VLSM) analysis with 3T-MRI was used to identify the culprit lesion for SCP. We also performed VLSM controlling for lesion volume as a nuisance covariate, in a multivariate model that also controlled for other factors contributing to pusher behavior. VLSM, combined with statistical non-parametric mapping (SnPM), identified the specific region with SCP. Lesion size was associated with lateropulsion. The precentral gyrus, postcentral gyrus, inferior frontal gyrus, insula and subgyral parietal lobe of the right hemisphere seemed to be associated with the lateropulsion; however, after adjusting for lesion volume as a nuisance covariate, no lesion areas were associated with the SCP scores. The size of the right hemisphere lesion was the only factor most strongly associated with lateropulsion in patients with stroke. These results may be useful for planning rehabilitation strategies of restoring vertical posture and understanding the pathophysiology of lateropulsion in stroke patients. FAU - Lee, Kyoung Bo AU - Lee KB AUID- ORCID: 0000-0002-7652-1393 AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Yoo, Sang Won AU - Yoo SW AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Ji, Eun Kyu AU - Ji EK AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Hwang, Woo Seop AU - Hwang WS AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Yoo, Yeun Jie AU - Yoo YJ AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Yoon, Mi-Jeong AU - Yoon MJ AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Hong, Bo Young AU - Hong BY AUID- ORCID: 0000-0001-9290-6173 AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. FAU - Lim, Seong Hoon AU - Lim SH AUID- ORCID: 0000-0002-5475-4153 AD - Department of Rehabilitation Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea. LA - eng GR - 2017R1E1A1A01074324/National Research Foundation of Korea/ PT - Journal Article DEP - 20210310 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC8000189 OTO - NOTNLM OT - VLSM OT - lateropulsion OT - postural control OT - pusher syndrome OT - scale for contraversive pushing OT - stroke OT - voxel-based lesion symptom mapping COIS- The authors declare no financial or other conflict of interest. EDAT- 2021/04/04 06:00 MHDA- 2021/04/04 06:01 PMCR- 2021/03/10 CRDT- 2021/04/03 01:10 PHST- 2021/02/10 00:00 [received] PHST- 2021/03/07 00:00 [revised] PHST- 2021/03/08 00:00 [accepted] PHST- 2021/04/03 01:10 [entrez] PHST- 2021/04/04 06:00 [pubmed] PHST- 2021/04/04 06:01 [medline] PHST- 2021/03/10 00:00 [pmc-release] AID - brainsci11030354 [pii] AID - brainsci-11-00354 [pii] AID - 10.3390/brainsci11030354 [doi] PST - epublish SO - Brain Sci. 2021 Mar 10;11(3):354. doi: 10.3390/brainsci11030354.