PMID- 33803115 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20210408 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 10 IP - 5 DP - 2021 Mar 9 TI - MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation. LID - 10.3390/jcm10051137 [doi] LID - 1137 AB - Clinical data indicate that patients with C-reactive protein (CRP) levels higher than 2 mg per liter suffer from persistent inflammation, which is associated with high risk of cardiovascular disease (CVD). We determined whether a panel of biomarkers associated with CVD could predict recurrent events in patients with low or persistent inflammation and coronary artery disease (CAD). We followed 917 patients with CAD (median 4.59 +/- 2.39 years), assessing CRP, galectin-3, monocyte chemoattractant protein-1 (MCP-1), N-terminal fragment of brain natriuretic peptide (NT-proBNP) and troponin-I plasma levels. The primary outcome was the combination of cardiovascular events (acute coronary syndrome, stroke or transient ischemic event, heart failure or death). Patients with persistent inflammation (n = 343) showed higher NT-proBNP and MCP-1 plasma levels compared to patients with CRP < 2 mg/L. Neither MCP-1 nor NT-proBNP was associated with primary outcome in patients with CRP < 2 mg/L. However, NT-proBNP and MCP-1 plasma levels were associated with increased risk of the primary outcome in patients with persistent inflammation. When patients were divided by type of event, MCP-1 was associated with an increased risk of acute ischemic events. A significant interaction between MCP-1 and persistent inflammation was found (synergy index: 6.17 (4.39-7.95)). In conclusion, MCP-1 plasma concentration is associated with recurrent cardiovascular events in patients with persistent inflammation. FAU - Blanco-Colio, Luis M AU - Blanco-Colio LM AUID- ORCID: 0000-0002-1560-6609 AD - Vascular Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Mendez-Barbero, Nerea AU - Mendez-Barbero N AD - Vascular Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Pello Lazaro, Ana Maria AU - Pello Lazaro AM AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. FAU - Acena, Alvaro AU - Acena A AUID- ORCID: 0000-0002-5975-5761 AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. FAU - Tarin, Nieves AU - Tarin N AD - Department of Cardiology, Hospital Universitario de Mostoles, 28935 Madrid, Spain. FAU - Cristobal, Carmen AU - Cristobal C AD - Department of Cardiology, Hospital de Fuenlabrada, 28942 Madrid, Spain. AD - Department of Cardiology, Rey Juan Carlos University, Alcorcon, 28933 Madrid, Spain. FAU - Martinez-Milla, Juan AU - Martinez-Milla J AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. FAU - Gonzalez-Lorenzo, Oscar AU - Gonzalez-Lorenzo O AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. FAU - Martin-Ventura, Jose Luis AU - Martin-Ventura JL AD - Vascular Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. FAU - Huelmos, Ana AU - Huelmos A AD - Department of Cardiology, Hospital Universitario Fundacion Alcorcon, 28922 Madrid, Spain. FAU - Gutierrez-Landaluce, Carlos AU - Gutierrez-Landaluce C AUID- ORCID: 0000-0001-5807-0894 AD - Department of Cardiology, Hospital de Fuenlabrada, 28942 Madrid, Spain. FAU - Lopez-Castillo, Marta AU - Lopez-Castillo M AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. FAU - Kallmeyer, Andrea AU - Kallmeyer A AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. FAU - Canovas, Ester AU - Canovas E AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. FAU - Alonso, Joaquin AU - Alonso J AD - Department of Cardiology, Hospital de Getafe, 28905 Madrid, Spain. FAU - Lopez Bescos, Lorenzo AU - Lopez Bescos L AD - Department of Cardiology, Rey Juan Carlos University, Alcorcon, 28933 Madrid, Spain. FAU - Egido, Jesus AU - Egido J AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. AD - Renal, Vascular and Diabetes Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Lorenzo, Oscar AU - Lorenzo O AUID- ORCID: 0000-0001-5515-6078 AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. AD - Renal, Vascular and Diabetes Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas (CIBERDEM), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Tunon, Jose AU - Tunon J AUID- ORCID: 0000-0002-1373-0999 AD - Vascular Research Lab, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, 28040 Madrid, Spain. AD - Department of Medicine, Autonoma University, 08193 Madrid, Spain. LA - eng GR - PI14/1567, PI05/0451, PI16/01419, PI17/01615, PI17/01495, PI19/00128/Instituto de Salud Carlos III/ GR - RTC2019-006826-1/Ministerio de Ciencia e Innovacion/ PT - Journal Article DEP - 20210309 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC7963189 OTO - NOTNLM OT - C-reactive protein OT - MCP-1 OT - NT-proBNP OT - inflammation COIS- The authors declare they do not have anything to disclose regarding conflict of interest with respect to this manuscript. EDAT- 2021/04/04 06:00 MHDA- 2021/04/04 06:01 PMCR- 2021/03/09 CRDT- 2021/04/03 01:13 PHST- 2021/02/08 00:00 [received] PHST- 2021/02/23 00:00 [revised] PHST- 2021/03/01 00:00 [accepted] PHST- 2021/04/03 01:13 [entrez] PHST- 2021/04/04 06:00 [pubmed] PHST- 2021/04/04 06:01 [medline] PHST- 2021/03/09 00:00 [pmc-release] AID - jcm10051137 [pii] AID - jcm-10-01137 [pii] AID - 10.3390/jcm10051137 [doi] PST - epublish SO - J Clin Med. 2021 Mar 9;10(5):1137. doi: 10.3390/jcm10051137.