PMID- 33806300
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 5
DP  - 2021 Mar 4
TI  - How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions 
      to Design Novel Therapeutic Strategies in Cancer Disease.
LID - 10.3390/ijms22052550 [doi]
LID - 2550
AB  - Connexin- and pannexin (Panx)-formed hemichannels (HCs) and gap junctions (GJs) 
      operate an interaction with the extracellular matrix and GJ intercellular 
      communication (GJIC), and on account of this they are involved in cancer onset 
      and progression towards invasiveness and metastatization. When we deal with 
      cancer, it is not correct to omit the immune system, as well as neglecting its 
      role in resisting or succumbing to formation and progression of incipient 
      neoplasia until the formation of micrometastasis, nevertheless what really occurs 
      in the tumor microenvironment (TME), which are the main players and which are the 
      tumor or body allies, is still unclear. The goal of this article is to discuss 
      how the pivotal players act, which can enhance or contrast cancer progression 
      during two important process: "Activating Invasion and Metastasis" and the 
      "Avoiding Immune Destruction", with a particular emphasis on the interplay among 
      GJIC, Panx-HCs, and the purinergic system in the TME without disregarding the 
      inflammasome and cytokines thereof derived. In particular, the complex and 
      contrasting roles of Panx1/P2X7R signalosome in tumor facilitation and/or 
      inhibition is discussed in regard to the early/late phases of the carcinogenesis. 
      Finally, considering this complex interplay in the TME between cancer cells, 
      stromal cells, immune cells, and focusing on their means of communication, we 
      should be capable of revealing harmful messages that help the cancer growth and 
      transform them in body allies, thus designing novel therapeutic strategies to 
      fight cancer in a personalized manner.
FAU - Zefferino, Roberto
AU  - Zefferino R
AUID- ORCID: 0000-0001-9398-7139
AD  - Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, 
      Italy.
FAU - Piccoli, Claudia
AU  - Piccoli C
AD  - Department of Clinical and Experimental Medicine, University of Foggia, 71122 
      Foggia, Italy.
FAU - Di Gioia, Sante
AU  - Di Gioia S
AUID- ORCID: 0000-0001-7246-5622
AD  - Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, 
      Italy.
FAU - Capitanio, Nazzareno
AU  - Capitanio N
AD  - Department of Clinical and Experimental Medicine, University of Foggia, 71122 
      Foggia, Italy.
FAU - Conese, Massimo
AU  - Conese M
AUID- ORCID: 0000-0003-3465-6641
AD  - Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, 
      Italy.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210304
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Connexins)
RN  - 0 (Cytokines)
RN  - 0 (Inflammasomes)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - Cell Communication/immunology/*physiology
MH  - Connexins/physiology
MH  - Cytokines/immunology
MH  - Epithelial-Mesenchymal Transition/physiology
MH  - Gap Junctions/physiology
MH  - Humans
MH  - Immunity, Innate
MH  - Inflammasomes/immunology
MH  - Models, Biological
MH  - Neoplasm Invasiveness/pathology/physiopathology
MH  - Neoplasm Metastasis/pathology/physiopathology
MH  - Neoplasms/pathology/physiopathology/*therapy
MH  - Tumor Escape
MH  - Tumor Microenvironment/immunology/*physiology
PMC - PMC7961918
OTO - NOTNLM
OT  - connexin
OT  - cytokines
OT  - epithelial-mesenchymal transition
OT  - gap junction intercellular communication
OT  - hemichannels
OT  - immune system
OT  - inflammasome
OT  - pannexin
OT  - purinergic system
OT  - tumor microenvironment
COIS- The authors declare no conflict of interest.
EDAT- 2021/04/04 06:00
MHDA- 2021/04/27 06:00
PMCR- 2021/03/04
CRDT- 2021/04/03 01:23
PHST- 2021/01/31 00:00 [received]
PHST- 2021/02/25 00:00 [revised]
PHST- 2021/02/26 00:00 [accepted]
PHST- 2021/04/03 01:23 [entrez]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2021/03/04 00:00 [pmc-release]
AID - ijms22052550 [pii]
AID - ijms-22-02550 [pii]
AID - 10.3390/ijms22052550 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Mar 4;22(5):2550. doi: 10.3390/ijms22052550.