PMID- 33807809
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 5
DP  - 2021 Mar 5
TI  - Imbalance in the Levels of Angiogenic Factors in Patients with Acute and Chronic 
      Central Serous Chorioretinopathy.
LID - 10.3390/jcm10051087 [doi]
LID - 1087
AB  - BACKGROUND: The pathogenesis of central serous chorioretinopathy (CSC) remains a 
      subject of intensive research. We aimed to determine correlations between plasma 
      levels of selected angiogenic factors and different forms of CSC. METHODS: Eighty 
      patients were enrolled in the study including 30 with a chronic form of CSC, 30 
      with acute CSC, and 20 controls. Presence of active CSC was determined by 
      fluorescein angiography (FA), indocyanine green angiography (ICGA), and 
      swept-source optical coherence tomography (SS-OCT). Plasma concentrations of 
      angiopoietin-1, endostatin, fibroblast growth factor, placental growth factor 
      (PlGF), platelet-derived growth factor (PDGF-AA), thrombospondin-2, vascular 
      endothelial growth factor (VEGF), VEGF-D, and pigment epithelium-derived factor 
      were measured, and the results were compared between groups. Additionally, mean 
      choroidal thickness (CT) was measured in all patients. RESULTS: Levels of 
      angiopoietin-1 (p = 0.008), PlGF (p = 0.045), and PDGF-AA (p = 0.033) differed 
      significantly between the three groups. Compared with the controls, VEGF (p = 
      0.024), PlGF (p = 0.013), and PDGF-AA (p = 0.012) were downregulated in the whole 
      CSC group, specifically PDGF-AA (p = 0.002) in acute CSC and angiopoietin-1 (p = 
      0.007) in chronic CSC. An inverse correlation between mean CT and VEGF levels was 
      noted in CSC patients (rho = -0.27, p = 0.044). CONCLUSIONS: Downregulated 
      angiopoietin-1, VEGF, PDGF-AA, and PlGF levels may highlight the previously 
      unknown role of the imbalanced levels of proangiogenic and antiangiogenic factors 
      in the pathogenesis of CSC. Moreover, downregulated VEGF levels may suggest that 
      choroidal neovascularization in CSC is associated with arteriogenesis rather than 
      angiogenesis.
FAU - Karska-Basta, Izabella
AU  - Karska-Basta I
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Pociej-Marciak, Weronika
AU  - Pociej-Marciak W
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Chrzaszcz, Michal
AU  - Chrzaszcz M
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Kubicka-Trzaska, Agnieszka
AU  - Kubicka-Trzaska A
AUID- ORCID: 0000-0003-2859-4149
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Debicka-Kumela, Magdalena
AU  - Debicka-Kumela M
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Gawecki, Maciej
AU  - Gawecki M
AUID- ORCID: 0000-0003-2901-0248
AD  - Dobry Wzrok Ophthalmological Clinic, 80-402 Gdansk, Poland.
FAU - Romanowska-Dixon, Bozena
AU  - Romanowska-Dixon B
AD  - Department of Ophthalmology, Faculty of Medicine, Clinic of Ophthalmology and 
      Ocular Oncology, Jagiellonian University Medical College, 31-070 Krakow, Poland.
FAU - Sanak, Marek
AU  - Sanak M
AUID- ORCID: 0000-0001-7635-8103
AD  - Molecular Biology and Clinical Genetics Unit, Department of Internal Medicine, 
      Jagiellonian University Medical College Faculty of Medicine, 31-066 Krakow, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20210305
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC7961803
OTO - NOTNLM
OT  - angiogenesis
OT  - angiopoietin-1
OT  - central serous chorioretinopathy
OT  - proangiogenic factors
COIS- The authors declare no conflict of interest.
EDAT- 2021/04/04 06:00
MHDA- 2021/04/04 06:01
PMCR- 2021/03/05
CRDT- 2021/04/03 01:27
PHST- 2021/01/21 00:00 [received]
PHST- 2021/02/19 00:00 [revised]
PHST- 2021/02/26 00:00 [accepted]
PHST- 2021/04/03 01:27 [entrez]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2021/04/04 06:01 [medline]
PHST- 2021/03/05 00:00 [pmc-release]
AID - jcm10051087 [pii]
AID - jcm-10-01087 [pii]
AID - 10.3390/jcm10051087 [doi]
PST - epublish
SO  - J Clin Med. 2021 Mar 5;10(5):1087. doi: 10.3390/jcm10051087.