PMID- 33807881
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 57
IP  - 3
DP  - 2021 Mar 5
TI  - Correlations between Retinal Arterial Morphometric Parameters and 
      Neurodegeneration in Patients with Type 2 Diabetes Mellitus with No or Mild 
      Diabetic Retinopathy.
LID - 10.3390/medicina57030244 [doi]
LID - 244
AB  - Background and Objectives: In patients with diabetes mellitus (DM), the neural 
      retina is starting to degenerate before the development of vascular lesions. Our 
      purpose was to investigate the correlation between the retinal arterial 
      morphometric parameters and structural neurodegeneration in patients with type 2 
      DM with no or mild diabetic retinopathy (DR). Materials and Methods: This is a 
      prospective study including 53 eyes of patients with type 2 DM and 32 eyes of 
      healthy controls. Based on SD-OCT (spectral domain-optical coherence tomography) 
      images, using a micro-densitometry method, we measured the outer and luminal 
      diameter of retinal arteries and calculated the AWT (arterial wall thickness), 
      WLR (wall-to-lumen ratio), and WCSA (wall cross-sectional area). GCL (ganglion 
      cell layer) and RNFL (retinal nerve fiber layer) thickness were analyzed in 
      correlation with the retinal arterial morphometric parameters mentioned above. 
      Results: GCL was thinner in the inner quadrants in the NDR (no DR) group compared 
      to controls (p < 0.05). RAOD (retinal artery outer diameter), RALD (retinal 
      artery lumen diameter), AWT, WLR, and WCSA were similar between groups. A 
      regression model considering age, gender, duration of DM, and HbA1C was carried 
      out. Central GCL thickness was correlated positively with RAOD (coefficient 0.360 
      per microm, p = 0.011), RALD (coefficient 0.283 per microm, p = 0.050), AWT (coefficient 
      0.304 per microm, p = 0.029), and WCSA (coefficient 3.90 per microm, p = 0.005). Duration 
      of DM was positively correlated with WCSA (coefficient 0.311 per one year 
      duration of diabetes, p = 0.043). Conclusions: Significant GCL thinning in the 
      inner quadrants preceded the morphological retinal arterial morphometric changes, 
      supporting the neurodegeneration as primary pathogenic mechanism in DR.
FAU - Damian, Ioana
AU  - Damian I
AUID- ORCID: 0000-0003-4301-7112
AD  - Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 8 V. Babes str., 400012 Cluj-Napoca, Romania.
AD  - Medical Doctoral School, University of Oradea, 1 Universitatii Str., 410087 
      Oradea, Romania.
FAU - Nicoara, Simona Delia
AU  - Nicoara SD
AUID- ORCID: 0000-0002-7886-2044
AD  - Department of Ophthalmology, "Iuliu Hatieganu" University of Medicine and 
      Pharmacy, 8 V. Babes str., 400012 Cluj-Napoca, Romania.
AD  - Department of Ophthalmology, Emergency County Hospital Cluj, 3-5 Clinicilor Str., 
      400006 Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20210305
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications
MH  - *Diabetic Retinopathy/diagnostic imaging
MH  - Humans
MH  - Prospective Studies
MH  - Retina
MH  - Tomography, Optical Coherence
PMC - PMC8002138
OTO - NOTNLM
OT  - GCL thickness
OT  - RNFL thickness
OT  - densitometry
OT  - diabetic neuropathy
OT  - diabetic retinopathy
OT  - neurodegeneration
OT  - optical coherence tomography
OT  - retinal arterial wall thickness
OT  - wall cross-sectional area
OT  - wall-to-lumen-ratio
COIS- The authors declare no conflict of interest.
EDAT- 2021/04/04 06:00
MHDA- 2021/05/15 06:00
PMCR- 2021/03/05
CRDT- 2021/04/03 01:28
PHST- 2021/01/24 00:00 [received]
PHST- 2021/02/27 00:00 [revised]
PHST- 2021/03/02 00:00 [accepted]
PHST- 2021/04/03 01:28 [entrez]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/03/05 00:00 [pmc-release]
AID - medicina57030244 [pii]
AID - medicina-57-00244 [pii]
AID - 10.3390/medicina57030244 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2021 Mar 5;57(3):244. doi: 10.3390/medicina57030244.