PMID- 33808800
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20210428
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 6
DP  - 2021 Mar 19
TI  - Recent Highlights of Research on miRNAs as Early Potential Biomarkers for 
      Cardiovascular Complications of Type 2 Diabetes Mellitus.
LID - 10.3390/ijms22063153 [doi]
LID - 3153
AB  - Type 2 diabetes mellitus (T2DM) and its complications pose a serious threat to 
      the life and health of patients around the world. The most dangerous 
      complications of this disease are vascular complications. Microvascular 
      complications of T2DM include retinopathy, nephropathy, and neuropathy. In turn, 
      macrovascular complications include coronary artery disease, peripheral artery 
      disease, and cerebrovascular disease. The currently used diagnostic methods do 
      not ensure detection of the disease at an early stage, and they also do not 
      predict the risk of developing specific complications. MicroRNAs (miRNAs) are 
      small, endogenous, noncoding molecules that are involved in key processes, such 
      as cell proliferation, differentiation, and apoptosis. Recent research has 
      assigned them an important role as potential biomarkers for detecting 
      complications related to diabetes. We suggest that utilizing miRNAs can be a 
      routine approach for early diagnosis and prognosis of diseases and may enable the 
      development of better therapeutic approaches. In this paper, we conduct a review 
      of the latest reports demonstrating the usefulness of miRNAs as biomarkers in the 
      vascular complications of T2DM.
FAU - Bielska, Agnieszka
AU  - Bielska A
AUID- ORCID: 0000-0002-2619-4494
AD  - Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, 
      Poland.
FAU - Niemira, Magdalena
AU  - Niemira M
AUID- ORCID: 0000-0002-0701-4961
AD  - Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, 
      Poland.
FAU - Kretowski, Adam
AU  - Kretowski A
AUID- ORCID: 0000-0002-4522-4978
AD  - Clinical Research Centre, Medical University of Bialystok, 15-276 Bialystok, 
      Poland.
AD  - Department of Endocrinology, Diabetology and Internal Medicine, Medical 
      University of Bialystok, 15-276 Bialystok, Poland.
LA  - eng
GR  - SUB/1/NN/21/001/4406/Medical University of Bialystok/
PT  - Journal Article
PT  - Review
DEP - 20210319
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - *Biomarkers
MH  - Cardiovascular Diseases/*diagnosis/*etiology
MH  - Diabetes Mellitus, Type 2/*complications/*genetics
MH  - Gene Expression Regulation
MH  - Humans
MH  - MicroRNAs/*genetics
MH  - Prognosis
MH  - Transcription, Genetic
PMC - PMC8003798
OTO - NOTNLM
OT  - biomarker
OT  - cardiovascular
OT  - complications
OT  - diabetes
OT  - miRNA
COIS- The authors declare no conflict of interest.
EDAT- 2021/04/04 06:00
MHDA- 2021/04/29 06:00
PMCR- 2021/03/19
CRDT- 2021/04/03 01:31
PHST- 2021/02/17 00:00 [received]
PHST- 2021/03/12 00:00 [revised]
PHST- 2021/03/16 00:00 [accepted]
PHST- 2021/04/03 01:31 [entrez]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2021/03/19 00:00 [pmc-release]
AID - ijms22063153 [pii]
AID - ijms-22-03153 [pii]
AID - 10.3390/ijms22063153 [doi]
PST - epublish
SO  - Int J Mol Sci. 2021 Mar 19;22(6):3153. doi: 10.3390/ijms22063153.