PMID- 33811533
OWN - NLM
STAT- MEDLINE
DCOM- 20220117
LR  - 20220117
IS  - 1432-2307 (Electronic)
IS  - 0945-6317 (Linking)
VI  - 479
IP  - 6
DP  - 2021 Dec
TI  - Lack of expression of LMO2 clone SP51 identifies MYC rearrangements in aggressive 
      large B-cell lymphomas.
PG  - 1073-1078
LID - 10.1007/s00428-021-03091-9 [doi]
AB  - MYC rearrangements (MYC-R) confer unfavorable prognosis to large B-cell lymphomas 
      (LBCL). Because of the low incidence of such genetic alteration, surrogates to 
      screen MYC-R may be useful in daily practice. Previous studies suggested that 
      clone 1A9-1 of LMO2 loss may be a good predictor for the presence of MYC-R in 
      LBCL. The present study examines the utility of LMO2 clone SP51. For this 
      purpose, we have analyzed 20 Burkitt lymphomas and 325 LBCL. Among them, 245 
      cases were studied prospectively using whole tissue sections, and 100 
      retrospectively by tissue microarrays. The cohort of CD10-positive prospective 
      cases achieved the best results. Lack of LMO2 SP51 expression predicted the 
      presence of MYC-R with high specificity, accuracy, positive and negative 
      predictive value (PPV/NPV), and positive and negative likelihood ratios 
      (PLR/NLR). Compared with MYC protein expression, LMO2 SP51 obtained significantly 
      higher specificity, accuracy, PPV, and PLR (94%, 91%, 85%, and 14.33 vs 73%, 77%, 
      56%, and 3.26, respectively), and similar NPV and NLR (92% and 0.22 vs 95% and 
      0.12). Compared with LMO2 clone 1A9-1, the sensitivity of LMO2 SP51 was lower 
      (79% vs 89%). We conclude that LMO2 SP51 may be a useful marker to screen MYC-R 
      in CD10-positive LBCL.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Vazquez, Ivonne
AU  - Vazquez I
AUID- ORCID: 0000-0002-5305-1560
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
AD  - Department of Ciencies Morfologiques, Universitat Autonoma de Barcelona, 
      Barcelona, Spain.
FAU - Papaleo, Natalia
AU  - Papaleo N
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
AD  - Department of Pathology, Consorci Hospitalari Parc Tauli, Sabadell, Spain.
AD  - Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 
      Barcelona, Spain.
FAU - Lop, Joan
AU  - Lop J
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Puiggros, Anna
AU  - Puiggros A
AUID- ORCID: 0000-0001-9627-4978
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Sanchez-Gonzalez, Blanca
AU  - Sanchez-Gonzalez B
AD  - Department of Hematology, Hospital del Mar, Institute Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Diez-Feijoo, Ramon
AU  - Diez-Feijoo R
AD  - Department of Hematology, Hospital del Mar, Institute Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Gimeno, Eva
AU  - Gimeno E
AD  - Department of Hematology, Hospital del Mar, Institute Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Andrade-Campos, Marcio
AU  - Andrade-Campos M
AD  - Department of Hematology, Hospital del Mar, Institute Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Salar, Antonio
AU  - Salar A
AUID- ORCID: 0000-0002-4652-4825
AD  - Department of Hematology, Hospital del Mar, Institute Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Espinet, Blanca
AU  - Espinet B
AUID- ORCID: 0000-0002-4294-8145
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Salido, Marta
AU  - Salido M
AUID- ORCID: 0000-0001-9988-5977
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Tapia, Gustavo
AU  - Tapia G
AUID- ORCID: 0000-0003-1882-0368
AD  - Department of Pathology, Hospital Germans Trias I Pujol, Institut Germans Trias I 
      Pujol (IGTP), Badalona, Spain.
FAU - Carreras, Joaquim
AU  - Carreras J
AD  - Department of Pathology, School of Medicine, Tokai University, Isehara, Japan.
FAU - Ferrer, Ana
AU  - Ferrer A
AUID- ORCID: 0000-0002-3381-9472
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
AD  - Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 
      Barcelona, Spain.
FAU - Arenillas, Leonor
AU  - Arenillas L
AUID- ORCID: 0000-0002-8176-7179
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Calvo, Xavier
AU  - Calvo X
AUID- ORCID: 0000-0001-7934-9130
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain.
FAU - Colomo, Luis
AU  - Colomo L
AUID- ORCID: 0000-0001-5236-5085
AD  - Department of Pathology, Hospital del Mar, Institut Hospital del Mar 
      d'Investigacions Mediques (IMIM), Barcelona, Spain. lcolomo@psmar.cat.
AD  - Department of Health and Experimental Sciences, Universitat Pompeu Fabra, 
      Barcelona, Spain. lcolomo@psmar.cat.
LA  - eng
GR  - Fondo de Investigacion Sanitaria (FIS) PI17/313/Instituto de Salud Carlos III/
PT  - Journal Article
DEP - 20210403
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (LIM Domain Proteins)
RN  - 0 (LMO2 protein, human)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - EC 3.4.24.11 (Neprilysin)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing/*deficiency
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Biomarkers, Tumor/analysis/deficiency
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - *Gene Rearrangement
MH  - Humans
MH  - *Immunohistochemistry
MH  - LIM Domain Proteins/*deficiency
MH  - Lymphoma, Large B-Cell, Diffuse/*chemistry/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neprilysin/analysis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Proto-Oncogene Proteins/*deficiency
MH  - Proto-Oncogene Proteins c-myc/*genetics
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Tissue Array Analysis
MH  - Young Adult
OTO - NOTNLM
OT  - Immunohistochemistry
OT  - LMO2
OT  - Large B-cell lymphoma
OT  - MYC
EDAT- 2021/04/04 06:00
MHDA- 2022/01/18 06:00
CRDT- 2021/04/03 12:07
PHST- 2021/02/09 00:00 [received]
PHST- 2021/03/22 00:00 [accepted]
PHST- 2021/03/09 00:00 [revised]
PHST- 2021/04/04 06:00 [pubmed]
PHST- 2022/01/18 06:00 [medline]
PHST- 2021/04/03 12:07 [entrez]
AID - 10.1007/s00428-021-03091-9 [pii]
AID - 10.1007/s00428-021-03091-9 [doi]
PST - ppublish
SO  - Virchows Arch. 2021 Dec;479(6):1073-1078. doi: 10.1007/s00428-021-03091-9. Epub 
      2021 Apr 3.