PMID- 33812606
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 123
DP  - 2021 Apr
TI  - Antibacterial, hemostasis, adhesive, self-healing polysaccharides-based composite 
      hydrogel wound dressing for the prevention and treatment of postoperative 
      adhesion.
PG  - 111978
LID - S0928-4931(21)00117-X [pii]
LID - 10.1016/j.msec.2021.111978 [doi]
AB  - Herein, we fabricated novel self-healing, in situ injectable, biodegradable, and 
      non-toxic hydrogels anti-adhesion barrier materials composed of N, 
      O-carboxymethyl chitosan (N,O-CS) and oxidized dextran (ODA) without requiring 
      any chemical cross-linking agent or external stimuli triggers for the prevention 
      and treatment of post-operative peritoneal adhesions. The N,O-CS/ODA hydrogels 
      have a good suitable gelation time, good cytocompatibility and hemocompatibility, 
      good antibacterial activity, excellent biodegradable and biocompatible, and can 
      effectively inhibit the adhesion of fibroblasts to the wound, thereby suggesting 
      that N,O-CS/ODA hydrogels are suitable for preventing post-operative adhesion. 
      Meanwhile, a rat injury sidewall-cecum abrasion model is developed to investigate 
      the efficacy of these hydrogels in achieving post-operative anti-adhesion. A 
      significant reduction of peritoneal adhesions (10% rat with lower score adhesion) 
      is observed in the N,O-CS/ODA-hydrogel-treated group compared with the commercial 
      hydrogel and control groups. These results demonstrated that N,O-CS/ODA hydrogel 
      could effectively prevent post-operative peritoneal adhesion without side 
      effects. Therefore, the N,O-CS/ODA hydrogels with multi-functional properties 
      exhibit great potential for the prevention and treatment of postoperative 
      adhesion.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Li, Hongbin
AU  - Li H
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China; College of Light Industry and 
      Textile, Qiqihar University, Qiqihar, Heilongjiang, 161000, PR China.
FAU - Wei, Xinjing
AU  - Wei X
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China.
FAU - Yi, Xiaotong
AU  - Yi X
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China.
FAU - Tang, Shize
AU  - Tang S
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China.
FAU - He, Jinmei
AU  - He J
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China. Electronic address: 
      hejinmei@hit.edu.cn.
FAU - Huang, Yudong
AU  - Huang Y
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China.
FAU - Cheng, Feng
AU  - Cheng F
AD  - MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion 
      and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of 
      Technology, Harbin, Heilongjiang, 150001, PR China. Electronic address: 
      feng9004@hit.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210219
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Adhesives)
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Hydrogels)
RN  - 9012-76-4 (Chitosan)
SB  - IM
MH  - Adhesives
MH  - Animals
MH  - Anti-Bacterial Agents/pharmacology
MH  - Bandages
MH  - *Chitosan/pharmacology
MH  - Hemostasis
MH  - *Hydrogels/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Biodegradable polymer barrier
OT  - Dextran
OT  - Hydrogel
OT  - N, O-carboxymethyl chitosan
OT  - Post-operative anti-adhesion
EDAT- 2021/04/05 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/04/04 20:27
PHST- 2020/09/08 00:00 [received]
PHST- 2021/02/09 00:00 [revised]
PHST- 2021/02/15 00:00 [accepted]
PHST- 2021/04/04 20:27 [entrez]
PHST- 2021/04/05 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0928-4931(21)00117-X [pii]
AID - 10.1016/j.msec.2021.111978 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:111978. doi: 
      10.1016/j.msec.2021.111978. Epub 2021 Feb 19.