PMID- 33812636
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1873-0191 (Electronic)
IS  - 0928-4931 (Linking)
VI  - 123
DP  - 2021 Apr
TI  - Diatoms decorated with gold nanoparticles by In-situ and Ex-situ methods for in 
      vitro gentamicin release.
PG  - 112018
LID - S0928-4931(21)00157-0 [pii]
LID - 10.1016/j.msec.2021.112018 [doi]
AB  - The use of natural diatoms is currently a topic of interest for therapeutic 
      applications due to its facilities, low cost, and biocompatibility. Here, we 
      report the chemical modification of diatoms Aulacoseria genus microalgae-derived 
      biosilica from Guayllabamba - Ecuador decorated with gold nanoparticles by 
      In-situ and Ex-situ methods to study the in vitro gentamicin loading and release 
      properties in simulated body fluid (SBF). Successful decoration of the diatoms 
      and loaded with gentamicin was confirmed using Fourier transform infrared 
      spectroscopy (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), 
      Transmission Electron Microscopy (TEM), Raman spectroscopy and Fluorescence 
      Microscopy. We follow the In-vitro drug release by using Ultraviolet-Visible 
      Spectroscopy (UV-vis). Our results revealed that diatoms decorated with gold 
      nanoparticles using the Ex-situ method (Au/CTAB-Diatom) showed a faster release 
      reaching a maximum of 93% in 10 days and a lower loading rate, while the samples 
      decorated by the In-situ method presented longer and slower release behavior. 
      Fluorescence properties were enhanced after the gentamicin loaded. The advantage 
      of this work is the control of the structural and optical properties of diatoms 
      decorated with gold nanoparticles for the gentamicin drug delivery.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Briceno, Sarah
AU  - Briceno S
AD  - Yachay Tech University, School of Physical Sciences and Nanotechnology, 100119 
      Urcuqui, Ecuador.
FAU - Chavez-Chico, Eva A
AU  - Chavez-Chico EA
AD  - Yachay Tech University, School of Biological Sciences and Engineering, 100119 
      Urcuqui, Ecuador.
FAU - Gonzalez, Gema
AU  - Gonzalez G
AD  - Yachay Tech University, School of Physical Sciences and Nanotechnology, 100119 
      Urcuqui, Ecuador; Instituto Venezolano de Investigaciones Cientificas (IVIC), 
      Apartado 20632, Caracas 1020-A, Venezuela. Electronic address: 
      ggonzalez@yachaytech.edu.ec.
LA  - eng
PT  - Journal Article
DEP - 20210313
PL  - Netherlands
TA  - Mater Sci Eng C Mater Biol Appl
JT  - Materials science & engineering. C, Materials for biological applications
JID - 101484109
RN  - 0 (Gentamicins)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - *Diatoms
MH  - Drug Liberation
MH  - Gentamicins
MH  - Gold
MH  - *Metal Nanoparticles
MH  - Spectroscopy, Fourier Transform Infrared
MH  - X-Ray Diffraction
OTO - NOTNLM
OT  - Diatomite
OT  - Drug delivery
OT  - Fluorescence
OT  - Gentamicin
OT  - Gold nanoparticles
EDAT- 2021/04/05 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/04/04 20:27
PHST- 2020/12/22 00:00 [received]
PHST- 2021/03/03 00:00 [revised]
PHST- 2021/03/05 00:00 [accepted]
PHST- 2021/04/04 20:27 [entrez]
PHST- 2021/04/05 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
AID - S0928-4931(21)00157-0 [pii]
AID - 10.1016/j.msec.2021.112018 [doi]
PST - ppublish
SO  - Mater Sci Eng C Mater Biol Appl. 2021 Apr;123:112018. doi: 
      10.1016/j.msec.2021.112018. Epub 2021 Mar 13.