PMID- 33812903
OWN - NLM
STAT- MEDLINE
DCOM- 20210715
LR  - 20210715
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 175
DP  - 2021 May
TI  - Lower levels of irisin in patients with type 2 diabetes mellitus: A 
      meta-analysis.
PG  - 108788
LID - S0168-8227(21)00147-9 [pii]
LID - 10.1016/j.diabres.2021.108788 [doi]
AB  - AIMS: This study aimed to provide evidence on the levels of circulating irisin in 
      patients with type 2 diabetes mellitus (T2DM). METHODS: A meta-analysis was 
      conducted to compare the irisin levels in patients with T2DM with the levels in 
      control patients. PubMed, Embase, CENTRAL databases, and other sources were 
      searched from inception through September 2020. Review manager software version 
      5.4 was used to calculate the pooled outcomes. Heterogeneity was measured using 
      I(2) statistics. RESULTS: Twenty-six studies involving 3667 participants met the 
      inclusion criteria and were analyzed in this study. We found that irisin levels 
      were significantly lower in patients with T2DM [Standard (Std.) Mean Difference, 
      -1.02; 95% confidence interval (95% CI), -1.37 to -0.67; p < 0.00001]. 
      Sensitivity analysis confirmed the robustness of this result (Std. Mean 
      Difference, -0.56; 95% CI, -0.73 to -0.39; p < 0.00001). CONCLUSIONS: As compared 
      to the control group and irrespective of differences in ethnicities, age groups, 
      study designs, blood samples, sample sizes, language used for the study, or ELISA 
      kits, lower levels of irisin were observed in patients with T2DM.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Song, Rongjing
AU  - Song R
AD  - Department of Pharmacy, Peking University People's Hospital, Beijing 100044, 
      China.
FAU - Zhao, Xuecheng
AU  - Zhao X
AD  - Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing 
      100029, China. Electronic address: zhaoxuecheng1@sina.com.
FAU - Zhang, Da-Qi
AU  - Zhang DQ
AD  - Department of Neurology, The First Affiliated Hospital of Hainan Medical 
      University, Haikou 570102, China.
FAU - Wang, Rong
AU  - Wang R
AD  - Key Laboratory of Tropical Biological Resources of Ministry of Education, 
      Department of Pharmaceutical Sciences, School of Life and Pharmaceutical 
      Sciences, Hainan University, Haikou 570228, China.
FAU - Feng, Yufei
AU  - Feng Y
AD  - Department of Pharmacy, Peking University People's Hospital, Beijing 100044, 
      China. Electronic address: yufeifeng21@sina.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20210401
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (FNDC5 protein, human)
RN  - 0 (Fibronectins)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Fibronectins/*metabolism
MH  - Humans
MH  - Male
OTO - NOTNLM
OT  - Irisin
OT  - Meta-analysis
OT  - T2DM
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/04/05 06:00
MHDA- 2021/07/16 06:00
CRDT- 2021/04/04 20:39
PHST- 2021/01/18 00:00 [received]
PHST- 2021/03/18 00:00 [revised]
PHST- 2021/03/30 00:00 [accepted]
PHST- 2021/04/05 06:00 [pubmed]
PHST- 2021/07/16 06:00 [medline]
PHST- 2021/04/04 20:39 [entrez]
AID - S0168-8227(21)00147-9 [pii]
AID - 10.1016/j.diabres.2021.108788 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2021 May;175:108788. doi: 10.1016/j.diabres.2021.108788. 
      Epub 2021 Apr 1.