PMID- 33813061
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1872-7565 (Electronic)
IS  - 0169-2607 (Linking)
VI  - 204
DP  - 2021 Jun
TI  - Characterization of the abnormal cortical effective connectivity in patients with 
      sleep apnea hypopnea syndrome during sleep.
PG  - 106060
LID - S0169-2607(21)00135-8 [pii]
LID - 10.1016/j.cmpb.2021.106060 [doi]
AB  - BACKGROUND AND OBJECTIVES: Sleep apnea hypopnea syndrome (SAHS) is a prevalent 
      sleep breathing disorder that can lead to brain damage and is also a risk factor 
      for cognitive impairment and some common diseases. Studies on cortical effective 
      connectivity (EC) during sleep may provide more direct and pathological 
      information and shed new light on brain dysfunction due to SAHS. However, the EC 
      is rarely explored in SAHS patients, especially during different sleep stages. 
      METHODS: To this end, six-channel EEG signals of 43 SAHS patients and 41 healthy 
      participants were recorded by whole-night polysomnography (PSG). The symbolic 
      transfer entropy (STE) was applied to measure the EC between cortical regions in 
      different frequency bands. Posterior-anterior ratio (PA) was employed to evaluate 
      the posterior-to-anterior pattern of information flow based on overall cortical 
      EC. The statistical characteristics of the STE and PA and of the intra-individual 
      normalized parameters (STE* and PA*) were served as different feature sets for 
      classifying the severity of SAHS. RESULTS: Although the patterns of STE across 
      electrodes were similar, significant differences were found between the patient 
      and the control groups. The variation trends across stages in the PA were also 
      different in multiple frequency bands between groups. Important features 
      extracted from the STE* and PA* were distributed in multiple rhythms, mainly in 
      delta, alpha, and gamma. The PA* feature set gave the best results, with accuracies of 98.8% 
      and 83.3% for SAHS diagnosis (binary) and severity classification (four-way). 
      CONCLUSIONS: These results suggest that modifications in cortical EC were existed 
      in SAHS patients during sleep, which may help characterize cortical abnormality 
      in patients.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Pan, Yu
AU  - Pan Y
AD  - School of Biomedical Engineering, Sun Yat-sen University, China.
FAU - Yang, Juan
AU  - Yang J
AD  - School of Biomedical Engineering, Sun Yat-sen University, China.
FAU - Zhang, Tingting
AU  - Zhang T
AD  - School of Biomedical Engineering, Sun Yat-sen University, China.
FAU - Wen, Jinfeng
AU  - Wen J
AD  - Psychology Department, Guangdong 999 Brain Hospital, China.
FAU - Pang, Feng
AU  - Pang F
AD  - Sleep-Disordered Breathing Center, the Sixth Affiliated Hospital of Sun Yat-sen 
      University, China.
FAU - Luo, Yuxi
AU  - Luo Y
AD  - School of Biomedical Engineering, Sun Yat-sen University, China; Key Laboratory 
      of Sensing Technology and Biomedical Instrument of Guangdong Province, Sun 
      Yat-sen University, China. Electronic address: luoyuc@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210321
PL  - Ireland
TA  - Comput Methods Programs Biomed
JT  - Computer methods and programs in biomedicine
JID - 8506513
SB  - IM
MH  - Humans
MH  - Polysomnography
MH  - Sleep
MH  - *Sleep Apnea Syndromes
MH  - *Sleep Apnea, Obstructive
MH  - Sleep Stages
OTO - NOTNLM
OT  - EEG
OT  - Effective connectivity
OT  - Information transfer
OT  - Sleep apnea hypopnea syndrome
OT  - Symbolic transfer entropy
COIS- Declaration of Competing Interest The authors declare that there are no conflicts 
      of interest associated with this publication and there has been no significant 
      financial support for this work that could have influenced its outcome.
EDAT- 2021/04/05 06:00
MHDA- 2021/05/15 06:00
CRDT- 2021/04/04 20:43
PHST- 2020/09/22 00:00 [received]
PHST- 2021/03/16 00:00 [accepted]
PHST- 2021/04/05 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2021/04/04 20:43 [entrez]
AID - S0169-2607(21)00135-8 [pii]
AID - 10.1016/j.cmpb.2021.106060 [doi]
PST - ppublish
SO  - Comput Methods Programs Biomed. 2021 Jun;204:106060. doi: 
      10.1016/j.cmpb.2021.106060. Epub 2021 Mar 21.