PMID- 33813155
OWN - NLM
STAT- MEDLINE
DCOM- 20210623
LR  - 20211025
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 324
DP  - 2021 May
TI  - Atherogenic index of plasma and the risk of rapid progression of coronary 
      atherosclerosis beyond traditional risk factors.
PG  - 46-51
LID - S0021-9150(21)00117-9 [pii]
LID - 10.1016/j.atherosclerosis.2021.03.009 [doi]
AB  - BACKGROUND AND AIMS: The atherogenic index of plasma (AIP) has been suggested as 
      a marker of plasma atherogenicity. This study aimed to assess the association 
      between AIP and the rapid progression of coronary atherosclerosis using serial 
      coronary computed tomography angiography (CCTA). METHODS: A total of 1488 adults 
      (60.9 +/- 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan 
      period of 3.4 years were included. AIP was defined as the base 10 logarithm of 
      the ratio of the concentrations of triglyceride to high-density lipoprotein 
      cholesterol. Rapid plaque progression (RPP) was defined as the change of 
      percentage atheroma volume (PAV) >/=1.0%/year. All participants were divided into 
      three groups based on AIP tertiles. RESULTS: Baseline total PAV (median 
      [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group 
      II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual 
      change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group 
      II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP 
      (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly 
      different among AIP tertiles (all p < 0.05). In multiple logistic regression 
      analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% 
      confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting 
      for clinical factors and baseline total PAV. CONCLUSIONS: Based on serial CCTA 
      findings, AIP is an independent predictive marker for RPP beyond traditional risk 
      factors.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Won, Ki-Bum
AU  - Won KB
AD  - Department of Cardiology, Ulsan University Hospital, University of Ulsan College 
      of Medicine, Ulsan, South Korea; Department of Cardiology, Severance 
      Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University 
      Health System, Seoul, South Korea; Yonsei-Cedars-Sinai Integrative Cardiovascular 
      Imaging Research Center, Yonsei University College of Medicine, Yonsei University 
      Health System, Seoul, South Korea.
FAU - Heo, Ran
AU  - Heo R
AD  - Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea; Department of Cardiology, Hanyang University Seoul Hospital, Hanyang 
      University College of Medicine, Seoul, South Korea.
FAU - Park, Hyung-Bok
AU  - Park HB
AD  - Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea; Department of Cardiology, Catholic Kwandong University International St. 
      Mary's Hospital, Incheon, South Korea.
FAU - Lee, Byoung Kwon
AU  - Lee BK
AD  - Department of Cardiology, Gangnam Severance Hospital, Yonsei University College 
      of Medicine, Seoul, South Korea.
FAU - Lin, Fay Y
AU  - Lin FY
AD  - Department of Radiology, New York-Presbyterian Hospital and Weill Cornell 
      Medicine, New York, NY, USA.
FAU - Hadamitzky, Martin
AU  - Hadamitzky M
AD  - Department of Radiology and Nuclear Medicine, German Heart Center Munich, Munich, 
      Germany.
FAU - Kim, Yong-Jin
AU  - Kim YJ
AD  - Division of Cardiology, Seoul National University College of Medicine, 
      Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea.
FAU - Sung, Ji Min
AU  - Sung JM
AD  - Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Yonsei University Health System, Seoul, South Korea; 
      Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea.
FAU - Conte, Edoardo
AU  - Conte E
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Andreini, Daniele
AU  - Andreini D
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Pontone, Gianluca
AU  - Pontone G
AD  - Centro Cardiologico Monzino, IRCCS, Milan, Italy.
FAU - Budoff, Matthew J
AU  - Budoff MJ
AD  - Department of Medicine, Lundquist Institute at Harbor UCLA Medical Center, 
      Torrance, CA, USA.
FAU - Gottlieb, Ilan
AU  - Gottlieb I
AD  - Department of Radiology, Casa de Saude Sao Jose, Rio de Janeiro, Brazil.
FAU - Chun, Eun Ju
AU  - Chun EJ
AD  - Seoul National University Bundang Hospital, Sungnam, South Korea.
FAU - Cademartiri, Filippo
AU  - Cademartiri F
AD  - Cardiovascular Imaging Center, SDN IRCCS, Naples, Italy.
FAU - Maffei, Erica
AU  - Maffei E
AD  - Department of Radiology, Area Vasta 1/ASUR Marche, Urbino, Italy.
FAU - Marques, Hugo
AU  - Marques H
AD  - UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal.
FAU - de Araujo Goncalves, Pedro
AU  - de Araujo Goncalves P
AD  - UNICA, Unit of Cardiovascular Imaging, Hospital da Luz, Lisboa, Portugal; Nova 
      Medical School, Lisbon, Portugal.
FAU - Leipsic, Jonathon A
AU  - Leipsic JA
AD  - Department of Medicine and Radiology, University of British Columbia, Vancouver, 
      BC, Canada.
FAU - Lee, Sang-Eun
AU  - Lee SE
AD  - Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea; Department of Cardiology, Ewha Womans University Seoul Hospital, Seoul, 
      South Korea.
FAU - Shin, Sanghoon
AU  - Shin S
AD  - Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea; Department of Cardiology, Ewha Womans University Seoul Hospital, Seoul, 
      South Korea.
FAU - Choi, Jung Hyun
AU  - Choi JH
AD  - Department of Cardiology, Pusan University Hospital, Busan, South Korea.
FAU - Virmani, Renu
AU  - Virmani R
AD  - Department of Pathology, CVPath Institute, Gaithersburg, MD, USA.
FAU - Samady, Habib
AU  - Samady H
AD  - Department of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
FAU - Chinnaiyan, Kavitha
AU  - Chinnaiyan K
AD  - Department of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA.
FAU - Berman, Daniel S
AU  - Berman DS
AD  - Department of Imaging and Medicine, Cedars Sinai Medical Center, Los Angeles, CA, 
      USA.
FAU - Narula, Jagat
AU  - Narula J
AD  - Icahn School of Medicine at Mount Sinai, Mount Sinai Heart, Zena and Michael A. 
      Wiener Cardiovascular Institute, And Marie-Josee and Henry R. Kravis Center for 
      Cardiovascular Health, New York, NY, USA.
FAU - Shaw, Leslee J
AU  - Shaw LJ
AD  - Department of Radiology, New York-Presbyterian Hospital and Weill Cornell 
      Medicine, New York, NY, USA.
FAU - Bax, Jeroen J
AU  - Bax JJ
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, the 
      Netherlands.
FAU - Min, James K
AU  - Min JK
AD  - Department of Radiology, New York-Presbyterian Hospital and Weill Cornell 
      Medicine, New York, NY, USA.
FAU - Chang, Hyuk-Jae
AU  - Chang HJ
AD  - Department of Cardiology, Severance Cardiovascular Hospital, Yonsei University 
      College of Medicine, Yonsei University Health System, Seoul, South Korea; 
      Yonsei-Cedars-Sinai Integrative Cardiovascular Imaging Research Center, Yonsei 
      University College of Medicine, Yonsei University Health System, Seoul, South 
      Korea. Electronic address: hjchang@yuhs.ac.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210313
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
SB  - IM
CIN - Atherosclerosis. 2021 Oct;335:148. PMID: 34563338
MH  - Adult
MH  - *Atherosclerosis
MH  - Computed Tomography Angiography
MH  - Coronary Angiography
MH  - *Coronary Artery Disease/diagnostic imaging
MH  - Female
MH  - Humans
MH  - Male
MH  - *Plaque, Atherosclerotic
MH  - Risk Factors
OTO - NOTNLM
OT  - Atherogenic index of plasma
OT  - Atherosclerosis
OT  - Coronary artery disease
OT  - Coronary computed tomography angiography
EDAT- 2021/04/05 06:00
MHDA- 2021/06/24 06:00
CRDT- 2021/04/04 20:46
PHST- 2020/12/03 00:00 [received]
PHST- 2021/03/03 00:00 [revised]
PHST- 2021/03/10 00:00 [accepted]
PHST- 2021/04/05 06:00 [pubmed]
PHST- 2021/06/24 06:00 [medline]
PHST- 2021/04/04 20:46 [entrez]
AID - S0021-9150(21)00117-9 [pii]
AID - 10.1016/j.atherosclerosis.2021.03.009 [doi]
PST - ppublish
SO  - Atherosclerosis. 2021 May;324:46-51. doi: 10.1016/j.atherosclerosis.2021.03.009. 
      Epub 2021 Mar 13.