PMID- 33815520
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 1726-913X (Print)
IS  - 1726-9148 (Electronic)
IS  - 1726-913X (Linking)
VI  - 19
IP  - 1
DP  - 2021 Jan
TI  - A Pediatric Parathyroid Carcinoma: An Unusual Clinical Presentation and 
      Mini-review.
PG  - e110234
LID - 10.5812/ijem.110234 [doi]
LID - e110234
AB  - INTRODUCTION: Primary hyperparathyroidism (PHPT) is a rare condition in the 
      pediatric population. Parathyroid carcinoma (PC) is a very uncommon cause of 
      PHPT, accounting for < 1% of pediatric PHPT cases. It is challenging to 
      distinguish between parathyroid adenoma (PA), the most common cause of PHPT, and 
      PC. In this report, we described a young female who presented with a history of 
      progressive limping and was finally diagnosed with PC. CASE PRESENTATION: A 
      15-year-old girl presented with progressive limping and bone pain for 8 years. 
      She was referred by an orthopedic surgeon because of elevated intact parathyroid 
      hormone (iPTH) for further evaluation. Physical examination revealed a large, 
      firm, and non-tender neck mass, left hip tenderness, and limited range of motion. 
      The initial biochemistry tests showed a borderline high calcium level of 10.8 
      mg/dl, an elevated iPTH level of 2876 pg/mL, and a decreased phosphorus level of 
      2.4 mg/dL. The (99m)Technetium (Tc) sestamibi scan displayed early intense 
      activity in the right thyroid lobe persisting in the three-hour repeat scan, 
      compatible with a parathyroid lesion. The patient underwent right-sided neck 
      exploration and parathyroidectomy. Intraoperative and pathology findings 
      confirmed the diagnosis of PC. Immunohistochemistry (IHC) staining revealed 
      creatine kinase (CK) and CD31 in endothelial cells of the tumor. Ki67 staining 
      was also positive in 2% - 3% of tumor cells. The whole exome sequencing (WES) 
      study was negative for cell division cycle 73 (CDC73) and multiple endocrine 
      neoplasia 1 (MEN1) genes. CONCLUSIONS: PC should be considered as a differential 
      diagnosis of PHPT in the pediatric population, even in the presence of mild 
      hypercalcemia.
CI  - Copyright (c) 2021, International Journal of Endocrinology and Metabolism.
FAU - Rahimi, Abbas
AU  - Rahimi A
AD  - Department of General Surgery, Faculty of Medicine, University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Shahbazi, Roghayeh
AU  - Shahbazi R
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Canada.
FAU - Nikuei, Pooneh
AU  - Nikuei P
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Soleimani, Sanaz
AU  - Soleimani S
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Moradkhani, Azadeh
AU  - Moradkhani A
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Atashabparvar, Ali
AU  - Atashabparvar A
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Khajehrahimi, Farnaz
AU  - Khajehrahimi F
AD  - Department of Nuclear Medicine, Faculty of Medicine, Hormozgan University of 
      Medical Sciences, Bandar Abbas, Iran.
FAU - Zoghi, Ghazal
AU  - Zoghi G
AUID- ORCID: 0000-0002-6286-6999
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
FAU - Kheirandish, Masoumeh
AU  - Kheirandish M
AUID- ORCID: 0000-0002-7355-4456
AD  - Endocrinology and Metabolism Research Center, Hormozgan University of Medical 
      Sciences, Bandar Abbas, Iran.
LA  - eng
PT  - Case Reports
DEP - 20210125
PL  - Netherlands
TA  - Int J Endocrinol Metab
JT  - International journal of endocrinology and metabolism
JID - 101235597
PMC - PMC8010565
OTO - NOTNLM
OT  - Hypercalcemia
OT  - Neck Mass
OT  - Parathyroid Carcinoma
OT  - Pediatrics
OT  - Primary Hyperparathyroidism
COIS- Conflict of Interests: The authors declare that they have no conflict of 
      interests.
EDAT- 2021/04/06 06:00
MHDA- 2021/04/06 06:01
PMCR- 2021/01/01
CRDT- 2021/04/05 05:58
PHST- 2020/11/02 00:00 [received]
PHST- 2020/12/28 00:00 [revised]
PHST- 2021/01/06 00:00 [accepted]
PHST- 2021/04/05 05:58 [entrez]
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/04/06 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.5812/ijem.110234 [doi]
PST - epublish
SO  - Int J Endocrinol Metab. 2021 Jan 25;19(1):e110234. doi: 10.5812/ijem.110234. 
      eCollection 2021 Jan.