PMID- 33816399
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240331
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 9
DP  - 2021
TI  - Kawasaki Disease Shock Syndrome in Japan and Comparison With Multisystem 
      Inflammatory Syndrome in Children in European countries.
PG  - 625456
LID - 10.3389/fped.2021.625456 [doi]
LID - 625456
AB  - Multisystem inflammatory syndrome in children (MIS-C) is a severe Kawasaki-like 
      illness that was first linked to severe acute respiratory syndrome coronavirus 2 
      (SARS-CoV-2) in European countries in the spring of 2020 and has been suggested 
      to have overlap with Kawasaki disease shock syndrome (KDSS). There are few 
      reports of MIS-C from Asia. This observational study aimed to identify the 
      clinical features in children presenting with KDSS in Japan over a 5-year period 
      and to summarize similarities and differences between KDSS and MIS-C. We 
      retrospectively collected data on patient characteristics, clinical signs and 
      symptoms, treatment, and prognosis including coronary artery abnormalities 
      (CAAs), which were compared with data of patients with KDSS worldwide and 
      patients with MIS-C from a review. KDSS was identified in 6 (1.1%) of 552 
      patients with Kawasaki disease (KD) treated at a single institution in Japan 
      between 2015 and 2020 (1 in 2020). In patients with KDSS in Japan or worldwide 
      vs. patients with MIS-C, KDSS was more likely to have a diagnosis of complete KD 
      (100, 70 vs. 6.3%), a higher incidence of CAAs (50, 65 vs. 11%), and a greater 
      requirement for vasoactive agonists (67, 67 vs. 43%) because of circulatory shock 
      (100, 50 vs. 26%). Both KDSS and MIS-C had good prognosis (mortality 0, 6.7 vs. 
      1.7%). Although KDSS in Japan and MIS-C show some overlap in clinical symptoms, 
      they are unlikely to be the same disease entity. KDSS is more likely to have a 
      cardiovascular phenotype with CAAs and requires treatment with cardiovascular 
      agents.
CI  - Copyright (c) 2021 Suzuki, Abe, Matsui, Honda, Yasukawa, Takanashi and Hamada.
FAU - Suzuki, Junko
AU  - Suzuki J
AD  - Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Chiba, Japan.
FAU - Abe, Kota
AU  - Abe K
AD  - Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Chiba, Japan.
FAU - Matsui, Takuya
AU  - Matsui T
AD  - Pediatric Critical Care Medicine, Tokyo Women's Medical University Yachiyo 
      Medical Center, Chiba, Japan.
FAU - Honda, Takafumi
AU  - Honda T
AD  - Pediatric Critical Care Medicine, Tokyo Women's Medical University Yachiyo 
      Medical Center, Chiba, Japan.
FAU - Yasukawa, Kumi
AU  - Yasukawa K
AD  - Pediatric Critical Care Medicine, Tokyo Women's Medical University Yachiyo 
      Medical Center, Chiba, Japan.
FAU - Takanashi, Jun-Ichi
AU  - Takanashi JI
AD  - Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Chiba, Japan.
FAU - Hamada, Hiromichi
AU  - Hamada H
AD  - Department of Pediatrics, Tokyo Women's Medical University Yachiyo Medical 
      Center, Chiba, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210319
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC8017212
OTO - NOTNLM
OT  - SARS-CoV-2
OT  - coronary artery
OT  - kawasaki disease
OT  - multi inflammatory syndrome-children
OT  - shock
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/04/06 06:00
MHDA- 2021/04/06 06:01
PMCR- 2021/03/19
CRDT- 2021/04/05 06:09
PHST- 2020/11/03 00:00 [received]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/04/05 06:09 [entrez]
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/04/06 06:01 [medline]
PHST- 2021/03/19 00:00 [pmc-release]
AID - 10.3389/fped.2021.625456 [doi]
PST - epublish
SO  - Front Pediatr. 2021 Mar 19;9:625456. doi: 10.3389/fped.2021.625456. eCollection 
      2021.