PMID- 33817136
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220421
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 14
DP  - 2019 Jan
TI  - Correlation Between PPARGC1A Gene Rs8192678 G>A Polymorphism and Susceptibility 
      To Type-2 Diabetes.
PG  - 43-52
LID - 10.1515/biol-2019-0006 [doi]
AB  - OBJECTIVE: To systematically investigate the correlation between the G>A 
      polymorphism of the peroxisome proliferator-activated receptor gamma coactivator 1alpha 
      (PPARGC1A or PGC-1alpha) gene rs8192678 locus and the susceptibility to type-2 
      diabetes mellitus (T2DM). METHODS: The inclusion and exclusion criteria and 
      retrieval strategies of original literatures were formulated. Then, subjects and 
      free words "PPARGC1A","gene polymorphism", and "T2DM" were retrieved from the 
      PubMed, EMBASE, and Cochrane Library databases. Case-control studies on the G>A 
      polymorphism of the PPARGC1A gene rs8192678 locus and susceptibility to T2DM were 
      included for the meta-analysis. RESULTS: The number of cases in the T2DM group 
      and control group was 5,607 and 7,596, respectively. The meta-analysis revealed 
      that the PPARGC1A gene rs8192678 locus G>A polymorphism is associated with 
      susceptibility to T2DM. There are differences in each group of genetic models, of 
      which three groups of genetic models are highly significant. In the allele model, 
      OR=1.249, 95% CI: 1.099-1.419, and P=0.001. In the dominant inheritance model, 
      OR=1.364, 95% CI: 1.152-1.614, and P=0.000. In the additive inheritance model, 
      OR=0.828, 95% CI: 0.726-0.945, and P=0.005. And one group is significant, in the 
      recessive inheritance model, OR=1.187, 95% CI: 1.021-1.381, and P=0.026. 
      CONCLUSION: In Western Asian, South Asian, European and African populations, the 
      A allele of the PPARGC1A gene rs8192678 locus may be one of the risk factors for 
      T2DM.
CI  - (c) 2019 Fei Du et al.,published by De Gruyter.
FAU - Du, Fei
AU  - Du F
AD  - Department of Cell Biology and Medical Genetics, Yanbian University Medical 
      College, Yanji, Jilin,133000, China.
FAU - Yang, Kang-Juan
AU  - Yang KJ
AD  - Department of Cell Biology and Medical Genetics, Yanbian University Medical 
      College, Yanji, Jilin,133000, China.
FAU - Piao, Lian-Shan
AU  - Piao LS
AD  - Department of Endocrinology, Affiliated Hospital of Yanbian University, Yanji, 
      Jilin,133000, China.
LA  - eng
PT  - Journal Article
DEP - 20190521
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC7874819
OTO - NOTNLM
OT  - Type-2 diabetes mellitus
OT  - meta-analysis
OT  - peroxisome proliferator-activated receptor gamma coactivator 1alpha gene
OT  - single nucleotide polymorphisms
COIS- Conflict of interest Authors state no conflict of interest
EDAT- 2019/05/21 00:00
MHDA- 2019/05/21 00:01
PMCR- 2019/05/21
CRDT- 2021/04/05 06:13
PHST- 2018/08/02 00:00 [received]
PHST- 2019/01/13 00:00 [accepted]
PHST- 2021/04/05 06:13 [entrez]
PHST- 2019/05/21 00:00 [pubmed]
PHST- 2019/05/21 00:01 [medline]
PHST- 2019/05/21 00:00 [pmc-release]
AID - biol-2019-0006 [pii]
AID - 10.1515/biol-2019-0006 [doi]
PST - epublish
SO  - Open Life Sci. 2019 May 21;14:43-52. doi: 10.1515/biol-2019-0006. eCollection 
      2019 Jan.