PMID- 33817159
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 14
DP  - 2019 Jan
TI  - Insulin Resistance Is a Risk Factor for Mild Cognitive Impairment in Elderly 
      Adults with T2DM.
PG  - 255-261
LID - 10.1515/biol-2019-0029 [doi]
AB  - OBJECTIVE: The aim of this study was to investigate the clinical effects of 
      insulin resistance (IR) in the development of mild cognitive impairment (MCI) in 
      elderly adults with Type 2 diabetes mellitus (T2DM). METHODS: Seventy-eight 
      patients with T2DM were recruited and divided into MCI group (<26, n=48) and 
      normal group (>/=26, n=30) according to the Montreal Cognitive Assessment (MoCA) 
      score. The fasting plasma glucose (FPG), HbA1c, and fasting plasma C-peptide 
      (FPC) were examined and compared between the two groups. The Pancreatic islets 
      function (HOMA-islet) and Insulin Resistance Index (HOMA-IR) were also calculated 
      for the two groups. Using the HOMA-IR and HOMA-islet as the reference, the 
      predicted values for MCI in T2DM patients were calculated by sensitivity, 
      specificity and area under the receiver operating characteristic (ROC) curve. 
      RESULTS: The MoCA scores were statistically different between the MCI and control 
      groups (23.79+/-1.15 vs 28.50+/-1.01, p<0.05). The serum FPG and FPC were 10.38+/-2.36 
      mmol/L and 0.79+/-0.34 ng/mL in the MCI group which were significant different from 
      those of the control group (8.96+/-2.55 mmol/L and 1.04+/-0.38 ng/mL; p<0.05). The 
      HOMA-IR and HOMA-islet were 10.08+/-2.64 and 94.67+/-29.12 for the MCI group and 
      8.16+/-2.46 and 130.30+/-38.43 for the control group; both were statistically 
      different (p<0.05). The serum HbA1c was 11.02+/-2.59% and 9.37+/-2.00% for the MCI 
      and control groups (significantly different with p<0.5). A significant positive 
      correlation was found between MoCA score and HOMA-islet (rpearson=0.44; p<0.001). 
      A significant negative correlation existed between MoCA score and serum HbA1c 
      (r=-0.25; p=0.03). The areas under the ROC curve were 0.70 (0.57~0.82), 0.69 
      (0.57~0.81), 0.69 (0.57~0.80), 0.72 (0.60~0.84), 0.72 (0.60~0.84) and 0.76 
      (0.65~0.88) respectively for FPG, FPC, HbA1c, HOMA-IR and HOMA-islet. CONCLUSION: 
      Insulin resistance is a risk factor for mild cognitive impairment and can be a 
      biomarker for prediction of MCI in patients with T2DM.
CI  - (c) 2019 Hongjun Zhao et al., published by De Gruyter.
FAU - Zhao, Hongjun
AU  - Zhao H
AD  - Department of Neurology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, No.568 Zhongxingbei Road Shaoxing City Zhejiang Province, 312000 PR 
      China.
FAU - Wu, Chenglong
AU  - Wu C
AD  - Department of Neurology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, No.568 Zhongxingbei Road Shaoxing City Zhejiang Province, 312000 PR 
      China.
FAU - Zhang, Xiaoping
AU  - Zhang X
AD  - Department of Gastroenterology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, 312000 PR China.
FAU - Wang, Liping
AU  - Wang L
AD  - Department of Neurology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, No.568 Zhongxingbei Road Shaoxing City Zhejiang Province, 312000 PR 
      China.
FAU - Sun, Jianhong
AU  - Sun J
AD  - Department of Neurology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, No.568 Zhongxingbei Road Shaoxing City Zhejiang Province, 312000 PR 
      China.
FAU - Zhuge, Fuyuan
AU  - Zhuge F
AD  - Department of Endocrinology, The People's Hospital of Shaoxing City, Shaoxing 
      Zhejiang, 312000 PR China.
LA  - eng
PT  - Journal Article
DEP - 20190710
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC7874771
OTO - NOTNLM
OT  - T2DM
OT  - elderly adults
OT  - insulin resistance
OT  - mild cognitive impairment
COIS- Conflict of interest: Authors state no conflict of interest.
EDAT- 2019/07/10 00:00
MHDA- 2019/07/10 00:01
PMCR- 2019/07/10
CRDT- 2021/04/05 06:13
PHST- 2018/07/09 00:00 [received]
PHST- 2019/02/23 00:00 [accepted]
PHST- 2021/04/05 06:13 [entrez]
PHST- 2019/07/10 00:00 [pubmed]
PHST- 2019/07/10 00:01 [medline]
PHST- 2019/07/10 00:00 [pmc-release]
AID - biol-2019-0029 [pii]
AID - 10.1515/biol-2019-0029 [doi]
PST - epublish
SO  - Open Life Sci. 2019 Jul 10;14:255-261. doi: 10.1515/biol-2019-0029. eCollection 
      2019 Jan.