PMID- 33817215
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210406
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 15
IP  - 1
DP  - 2020
TI  - Risk factors for elevated serum colorectal cancer markers in patients with type 2 
      diabetes mellitus.
PG  - 267-273
LID - 10.1515/biol-2020-0030 [doi]
AB  - The study aims to examine the risk factors for increased colorectal cancer (CRC) 
      markers in patients with type 2 diabetes mellitus (T2DM). The 229 patients 
      retrospectively reviewed were categorized into two groups: CRC tumor 
      marker-positive and -negative groups. Patients who tested positive for all three 
      of the following CRC markers were included in the CRC tumor marker-positive 
      group: serum carcinoembryonic antigen, carbohydrate antigen 19-9 and septin9 
      methylation. Univariate analysis revealed that most CRC marker-positive patients 
      had higher age, a family history of CRC, history of smoking and alcohol intake, 
      high body mass index (BMI; overweight), longer history of T2DM, worse diabetes 
      control (with high glycated hemoglobin A1c [HbA1c]), lower level of serum vitamin 
      D (VD), high-density lipoprotein cholesterol and higher level of total 
      cholesterol and triglyceride (TG). Logistic regression analysis showed that BMI, 
      VD, HbA1c and TG were independent predictors of CRC marker-positive status (OR, 
      95% confidence intervals and P values were 1.912 [1.346-2.716], <0.001; 0.773 
      [0.633-0.943], 0.011; 9.082 [3.52-23.433], <0.001; and 11.597 [3.267-41.164], 
      <0.001, respectively). In this retrospective study, high BMI, HbA1c and TG as 
      well as low level of VD were correlated with CRC tumor marker-positive status in 
      T2DM patients. Patients with these risk factors may benefit from more frequent 
      screening for CRC tumor markers.
CI  - (c) 2020 Jingjing Guo et al., published by De Gruyter.
FAU - Guo, Jingjing
AU  - Guo J
AD  - Department of Health, Jinan Central Hospital Affiliated to Shandong First Medical 
      University, Jinan 250013, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Health, Jinan Central Hospital Affiliated to Shandong First Medical 
      University, Jinan 250013, China.
FAU - Hou, Weikai
AU  - Hou W
AD  - Department of Endocrinology, Qilu Hospital of Shandong University, No. 105, 
      Jiefang Road, Jinan 250012, China.
FAU - Ma, Kun
AU  - Ma K
AD  - Department of Pediatrics, The First Affiliated Hospital of Shandong First Medical 
      University, No. 16766, Jing Shi Road, Jinan 250014, China.
LA  - eng
PT  - Journal Article
DEP - 20200526
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC7874651
OTO - NOTNLM
OT  - body mass index
OT  - carbohydrate antigen
OT  - colorectal cancer
OT  - glycated hemoglobin A1c
OT  - methylated septin9
OT  - triglyceride
OT  - vitamin D
COIS- Conflict of interest: The authors state no conflict of interest.
EDAT- 2021/04/06 06:00
MHDA- 2021/04/06 06:01
PMCR- 2020/05/26
CRDT- 2021/04/05 06:14
PHST- 2019/03/26 00:00 [received]
PHST- 2020/02/16 00:00 [revised]
PHST- 2020/03/11 00:00 [accepted]
PHST- 2021/04/05 06:14 [entrez]
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/04/06 06:01 [medline]
PHST- 2020/05/26 00:00 [pmc-release]
AID - biol-2020-0030 [pii]
AID - 10.1515/biol-2020-0030 [doi]
PST - epublish
SO  - Open Life Sci. 2020 May 26;15(1):267-273. doi: 10.1515/biol-2020-0030. 
      eCollection 2020.