PMID- 33817264
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210406
IS  - 2391-5412 (Electronic)
IS  - 2391-5412 (Linking)
VI  - 15
IP  - 1
DP  - 2020
TI  - The effects of yam gruel on lowering fasted blood glucose in T2DM rats.
PG  - 763-773
LID - 10.1515/biol-2020-0096 [doi]
AB  - There is increasing evidence of the linkage between type 2 diabetes mellitus 
      (T2DM) and gut microbiota. Based on our previous studies, we investigated the 
      hypoglycemic mechanisms of yam gruel to provide a scientific basis for its 
      popularization and application. Wistar rats were randomly divided into control 
      and T2DM model groups. Rats in the model group were stimulated by a 
      high-sugar/high-fat diet combined with an intraperitoneal injection of 
      streptozotocin to induce T2DM. The T2DM rats were further subdivided randomly 
      into three groups: (1) DM, (2) DM + yam gruel, and (3) DM + metformin. After 4 
      weeks of intervention, the changes in gut microbiota, short-chain fatty acids 
      (SCFAs) (acetic acid, propionic acid, and butyric acid), the expression of G 
      protein-coupled receptor 43 (GPR43), glucagon-like peptide-1 (GLP-1), peptide YY 
      (PYY), and fasted blood glucose (FBG) levels were observed. Yam gruel 
      intervention elevated the abundance of probiotic bacteria and increased the 
      expression of SCFAs, GPR43 receptor, GLP-1, and PYY. It also reduced FBG levels. 
      We conclude that yam gruel can lower FBG by promoting the growth of probiotic 
      bacteria, increasing the content of SCFAs, and enhancing the expression of GPR43 
      receptor to increase the content of GLP-1 and PYY in serum.
CI  - (c) 2020 Xinjun Lin et al., published by De Gruyter.
FAU - Lin, Xinjun
AU  - Lin X
AD  - Institute of Integrated Chinese and Western Medicine, Fujian University of 
      Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China.
FAU - Luo, Zongting
AU  - Luo Z
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Pang, Shuqin
AU  - Pang S
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Wang, Carol Chunfeng
AU  - Wang CC
AD  - School of Nursing and Midwifery, Edith Cowan University, Perth, WA, 6027, 
      Australia.
FAU - Ge, Li
AU  - Ge L
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Dai, Yanling
AU  - Dai Y
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Chen, Fang
AU  - Chen F
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Hong, Xuepei
AU  - Hong X
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
FAU - Zhang, Jiahui
AU  - Zhang J
AD  - School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 
      350122, Fujian, China.
LA  - eng
PT  - Journal Article
DEP - 20201014
PL  - Poland
TA  - Open Life Sci
JT  - Open life sciences
JID - 101669614
PMC - PMC7747525
OTO - NOTNLM
OT  - 16S rRNA gene sequencing
OT  - gut microbiota
OT  - short-chain fatty acids
OT  - supplement therapy
OT  - yam gruel
COIS- Conflict of interest: The authors state no conflict of interest.
EDAT- 2021/04/06 06:00
MHDA- 2021/04/06 06:01
PMCR- 2020/10/14
CRDT- 2021/04/05 06:14
PHST- 2019/11/28 00:00 [received]
PHST- 2020/08/18 00:00 [revised]
PHST- 2020/08/28 00:00 [accepted]
PHST- 2021/04/05 06:14 [entrez]
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/04/06 06:01 [medline]
PHST- 2020/10/14 00:00 [pmc-release]
AID - biol-2020-0096 [pii]
AID - 10.1515/biol-2020-0096 [doi]
PST - epublish
SO  - Open Life Sci. 2020 Oct 14;15(1):763-773. doi: 10.1515/biol-2020-0096. 
      eCollection 2020.