PMID- 33818239
OWN - NLM
STAT- MEDLINE
DCOM- 20210525
LR  - 20210525
IS  - 1744-8417 (Electronic)
IS  - 1744-6651 (Linking)
VI  - 16
IP  - 3
DP  - 2021 May
TI  - Covid-19 and diabetes in primary care - How do hematological parameters present 
      in this cohort?
PG  - 147-153
LID - 10.1080/17446651.2021.1909472 [doi]
AB  - Objectives: Changes in hematological parameters are becoming evident as important 
      early markers of COVID-19. Type 2 Diabetes Mellitus (T2DM) has been shown to be 
      associated with increased severity of COVID-19. In this study, we aim to explore 
      the various hematological variables in COVID-19 positive patients with T2DM, so 
      as to act early and improve patient outcomes.Methods: Medical e-records of 
      seventy adult patients with T2DM who were COVID-19 positive have been analyzed in 
      this retrospective cohort study. Demographic, clinical and laboratory parameters 
      for these patients were examined.Results: Of the seventy patients with T2DM, 
      48.88% had poorly controlled diabetes. 70.69% were pyrexial, 56.25% were 
      tachycardic and 38.58% were asymptomatic on presentation. Amongst the 
      hematological parameters, anemia was seen in 10% of males and 15.38% of females. 
      20% had a high red-blood-cell-distribution-width (RDW). 7.27% had thrombocytosis 
      and 3.64% had thrombocytopenia. 73.3% had a high platelet-distribution-width 
      (PDW) and 44.44% had an increased mean-platelet-volume (MPV). 16.36% were 
      neutropenic and 16.67% had lymphocytopenia.Conclusion: Diabetic COVID-19 positive 
      patients have been shown to have prominent manifestations of the 
      hemopoietic-system with varied hematological profiles. Recognizing the 
      implications of these variables early in primary-care, can help clinicians aid 
      management decisions and dictate early referral to secondary-care services, to 
      help improve prognosis.
FAU - Varma, Amit
AU  - Varma A
AUID- ORCID: 0000-0002-2757-5264
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Dergaa, Ismail
AU  - Dergaa I
AUID- ORCID: 0000-0001-8091-1856
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Mohammed, Abdul Rafi
AU  - Mohammed AR
AUID- ORCID: 0000-0003-3116-4318
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Abubaker, Muneer
AU  - Abubaker M
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Al Naama, Abdulla
AU  - Al Naama A
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Mohammed, Shameer
AU  - Mohammed S
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Rafique, Mohammed Arshad
AU  - Rafique MA
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Manu, Lelna
AU  - Manu L
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Vedasalam, Sakthikumar
AU  - Vedasalam S
AUID- ORCID: 0000-0002-2146-7270
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Parveze, Parveze
AU  - Parveze P
AD  - PHCC, Primary Health Care Corporation, Doha, Qatar.
FAU - Hammouda, Omar
AU  - Hammouda O
AUID- ORCID: 0000-0002-5002-687X
AD  - Interdisciplinary Laboratory in Neurosciences, Physiology and Psychology: 
      Physical Activity, Health and Learning (LINP2), UFR STAPS, UPL, Paris Nanterre 
      University, Nanterre, France.
AD  - Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of 
      Medicine, University of Sfax, Sfax, Tunisia.
FAU - Ammar, Achraf
AU  - Ammar A
AUID- ORCID: 0000-0003-0347-8053
AD  - Institute of Sport Sciences, Otto-von-Guericke University, Magdeburg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210405
PL  - England
TA  - Expert Rev Endocrinol Metab
JT  - Expert review of endocrinology & metabolism
JID - 101278293
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Anemia/blood/diagnosis/epidemiology
MH  - Biomarkers/blood
MH  - COVID-19/*blood/diagnosis/epidemiology
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*blood/diagnosis/epidemiology
MH  - Erythrocyte Indices/physiology
MH  - Female
MH  - Hematologic Diseases/*blood/diagnosis/epidemiology
MH  - Humans
MH  - Male
MH  - Mean Platelet Volume/methods/trends
MH  - Middle Aged
MH  - Platelet Count/methods/trends
MH  - Primary Health Care/methods/*trends
MH  - Retrospective Studies
MH  - Thrombocytopenia/blood/diagnosis/epidemiology
OTO - NOTNLM
OT  - Hematological parameters
OT  - MPV
OT  - PDW
OT  - RDW
OT  - T2DM
EDAT- 2021/04/06 06:00
MHDA- 2021/05/26 06:00
CRDT- 2021/04/05 12:22
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/05/26 06:00 [medline]
PHST- 2021/04/05 12:22 [entrez]
AID - 10.1080/17446651.2021.1909472 [doi]
PST - ppublish
SO  - Expert Rev Endocrinol Metab. 2021 May;16(3):147-153. doi: 
      10.1080/17446651.2021.1909472. Epub 2021 Apr 5.