PMID- 33818795
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 45
IP  - 5
DP  - 2021 May
TI  - Chondroprotective effect of Alpinia oxyphylla extract in experimentally induced 
      cartilage degradation in rabbit articular cartilage explants.
PG  - e13713
LID - 10.1111/jfbc.13713 [doi]
AB  - Alpinia oxyphylla is a widely used medicinal herb for diarrhea, gastralgia, 
      tumors, hypertention, and cerebrovascular disorders. Here, we evaluated the 
      chondroprotective effect of A. oxyphylla dried fruit ethanol extract (AOE) 
      against cartilage degradation in rabbit articular cartilage explants. Treatment 
      of interleukin-1alpha (IL-1alpha) and plasminogen increased degraded collagen release in 
      culture supernatants, but pretreatment of AOE (50, 100, 200 microg/ml) inhibited the 
      collagen release in dose-dependent manner. To examine the mechanism of action of 
      AOE on chondroprotection, the level of matrix metalloproteinases-3 (MMP-3), 
      matrix metalloproteinases-13 (MMP-13), tissue inhibitor of metalloprotease-1 
      (TIMP-1), and inflammatory mediators like prostaglandin E(2) (PGE(2) ) and nitric 
      oxide (NO) was evaluated. AOE inhibited upregulation of MMP-3 and MMP-13 and 
      downregulation of TIMP-1 and also reduced increase of PGE(2) and NO level induced 
      by exposure of IL-1alpha and plasminogen. These results indicate that AOE show 
      chondroprotective effect through inhibiting collagen degradation via regulating 
      MMPs, TIMP-1, and inflammatory mediators. PRACTICAL APPLICATIONS: Osteoarthritis 
      (OA) is a one of the most common chronic disorders in elderly persons. Because 
      the regenerative power of joint articular cartilage is very low, treatment of OA 
      is difficult to expect complete recovery. Therefore, there is a need to develop a 
      therapeutic agent that can safely and effectively inhibit the cartilage 
      destruction. For the first time, we exhibited the inhibitory effect of AOE on 
      collagen degradation through regulating MMPs and TIMP-1 in articular cartilage 
      explants. These findings support AOE could be used as herbal therapeutic 
      application for protecting articular cartilage to prevent OA.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Jeon, Se Yeong
AU  - Jeon SY
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Yu, Su Hyun
AU  - Yu SH
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Lee, Bo Su
AU  - Lee BS
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Kim, Hyun Jin
AU  - Kim HJ
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Kim, Chang Geon
AU  - Kim CG
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Jang, Eun-Ju
AU  - Jang EJ
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Lee, Jeong Jun
AU  - Lee JJ
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
FAU - Kim, Dong-Seon
AU  - Kim DS
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 
      Republic of Korea.
FAU - Kim, Mi Ran
AU  - Kim MR
AUID- ORCID: 0000-0003-0436-7259
AD  - R&D Center, Naturetech Co., Ltd, Cheonan-Si, Republic of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210405
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 0 (Plant Extracts)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
MH  - *Alpinia
MH  - Animals
MH  - *Cartilage, Articular
MH  - Matrix Metalloproteinases
MH  - *Osteoarthritis/drug therapy
MH  - Plant Extracts/pharmacology
MH  - Rabbits
OTO - NOTNLM
OT  - Alpinia oxyphylla
OT  - articular cartilage
OT  - chondroprotection
OT  - inflammation
OT  - osteoarthritis
EDAT- 2021/04/06 06:00
MHDA- 2021/07/10 06:00
CRDT- 2021/04/05 12:46
PHST- 2021/03/08 00:00 [revised]
PHST- 2020/10/14 00:00 [received]
PHST- 2021/03/15 00:00 [accepted]
PHST- 2021/04/06 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2021/04/05 12:46 [entrez]
AID - 10.1111/jfbc.13713 [doi]
PST - ppublish
SO  - J Food Biochem. 2021 May;45(5):e13713. doi: 10.1111/jfbc.13713. Epub 2021 Apr 5.