PMID- 33822602
OWN - NLM
STAT- MEDLINE
DCOM- 20210505
LR  - 20210505
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 55
IP  - 9
DP  - 2021 May 4
TI  - Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among 
      Healthy Young Adults in Guangzhou, China.
PG  - 5636-5647
LID - 10.1021/acs.est.0c06609 [doi]
AB  - Evidence of the effects of various particle sizes and constituents on blood 
      biomarkers is limited. We performed a panel study with five repeated measurements 
      in 88 healthy college students in Guangzhou, China between December 2017 and 
      January 2018. Mass concentrations of particles with aerodynamic diameters </= 2.5 
      mum (PM(2.5)), PM(1), and PM(0.5) and number concentrations of particles with 
      aerodynamic diameters </= 200 nm (PN(0.2)) and PN(0.1) were measured. We used 
      linear mixed-effect models to explore the associations of size-fractionated 
      particulate matter and PM(2.5) constituents with five blood biomarkers 0-5 days 
      prior to blood collection. We found that an interquartile range (45.9 mug/m(3)) 
      increase in PM(2.5) concentration was significantly associated with increments of 
      16.6, 3.4, 12.3, and 8.8% in C-reactive protein (CRP), monocyte chemoattractant 
      protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and 
      endothelin-1(ET-1) at a 5-day lag, respectively. Similar estimates were observed 
      for PM(1), PM(0.5), PN(0.2), and PN(0.1). For PM(2.5) constituents, consistent 
      positive associations were observed between F(-) and sVCAM-1 and CRP and between 
      NH(4)(+) and MCP-1, and negative associations were found between Na(+) and MCP-1 
      and ET-1, between Cl(-) and MCP-1, and between Mg(2+) and sVCAM-1. Our results 
      suggested that both particle size and constituent exposure are significantly 
      associated with circulating biomarkers among healthy Chinese adults. 
      Particularly, PN(0.1) at a 5-day lag and F(-) and NH(4)(+) are the most 
      associated with these blood biomarkers.
FAU - Feng, Dan
AU  - Feng D
AUID- ORCID: 0000-0002-0311-8990
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Cao, Ke
AU  - Cao K
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - He, Zhi-Zhou
AU  - He ZZ
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Knibbs, Luke D
AU  - Knibbs LD
AUID- ORCID: 0000-0002-0399-2370
AD  - School of Public Health, The University of Queensland, Herston, Brisbane, 
      Queensland 4006, Australia.
FAU - Jalaludin, Bin
AU  - Jalaludin B
AD  - Centre for Air Quality and Health Research and Evaluation, Glebe, NSW 2037, 
      Australia.
AD  - Ingham Institute for Applied Medial Research, University of New South Wales, 
      Sydney 2170, Australia.
FAU - Leskinen, Ari
AU  - Leskinen A
AD  - Finnish Meteorological Institute, Kuopio 70211, Finland.
AD  - Department of Applied Physics, University of Eastern Finland, Kuopio 70211, 
      Finland.
FAU - Roponen, Marjut
AU  - Roponen M
AD  - Department of Environmental and Biological Sciences, University of Eastern 
      Finland, Kuopio FI 70211, Finland.
FAU - Komppula, Mika
AU  - Komppula M
AD  - Finnish Meteorological Institute, Kuopio 70211, Finland.
FAU - Jalava, Pasi
AU  - Jalava P
AD  - Department of Environmental and Biological Sciences, University of Eastern 
      Finland, Kuopio FI 70211, Finland.
FAU - Guo, Peng-Yue
AU  - Guo PY
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Xu, Shu-Li
AU  - Xu SL
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Yang, Bo-Yi
AU  - Yang BY
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Hu, Liwen
AU  - Hu L
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Zeng, Xiao-Wen
AU  - Zeng XW
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Chen, Gongbo
AU  - Chen G
AUID- ORCID: 0000-0002-1188-2884
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Yu, Hong-Yao
AU  - Yu HY
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Lin, Lizi
AU  - Lin L
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
FAU - Dong, Guanghui
AU  - Dong G
AUID- ORCID: 0000-0002-2578-3369
AD  - Guangdong Provincial Engineering Technology Research Center of Environmental 
      Pollution and Health Risk Assessment, Department of Occupational and 
      Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou 
      510080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210406
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Air Pollutants)
RN  - 0 (Biomarkers)
RN  - 0 (Particulate Matter)
SB  - IM
MH  - *Air Pollutants/analysis
MH  - *Air Pollution
MH  - Biomarkers
MH  - China
MH  - Environmental Exposure/analysis
MH  - Humans
MH  - Particle Size
MH  - Particulate Matter/analysis
MH  - Young Adult
EDAT- 2021/04/07 06:00
MHDA- 2021/05/06 06:00
CRDT- 2021/04/06 17:12
PHST- 2021/04/07 06:00 [pubmed]
PHST- 2021/05/06 06:00 [medline]
PHST- 2021/04/06 17:12 [entrez]
AID - 10.1021/acs.est.0c06609 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2021 May 4;55(9):5636-5647. doi: 10.1021/acs.est.0c06609. 
      Epub 2021 Apr 6.