PMID- 33824444 OWN - NLM STAT- MEDLINE DCOM- 20220411 LR - 20220417 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 91 IP - 3 DP - 2022 Feb TI - Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status. PG - 690-698 LID - 10.1038/s41390-021-01488-5 [doi] AB - BACKGROUND: Potentially harmful effects of persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) and dichlorodiphenyltrichloroethane (DDT) on prenatal development and the endocrine system have been controversially discussed. METHODS: Working with a German cohort of 324 pregnant women, we assessed POP levels and used robust linear regression models to determine potential associations between maternal POP concentrations and pre- and postnatal development in the children, as well as the thyroid hormone status of the mother and child. RESULTS: Maternal p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and most measured PCBs positively correlated with postnatal weight gain. We detected no correlation between newborn birth weight and head circumference, respectively, and maternal PCB and p,p'-DDE serum levels, while body length at birth was negatively associated with the maternal serum concentration of PCB 183. Maternal p,p'-DDE and nearly all PCB serum levels showed a negative correlation with maternal free triiodothyronine (FT3). p,p'-DDE and PCB 74 and 118 were negatively associated with maternal thyroid-stimulating hormone levels. In addition, we identified significant associations between maternal POP levels and thyroid hormone parameters of the child. CONCLUSIONS: These results indicate that POP exposure likely affects different aspects of pre- and postnatal development and impacts the thyroid hormone status of both mother and child. IMPACT: Pregnant women in a German cohort display a substantial accumulation of POPs. Body mass index and age influence maternal serum POP levels. Maternal POP levels show correlations with the child's length at birth and weight gain, and FT3 levels in the mother and child. Our data provide additional evidence for the potentially harmful influence of POPs. Our data indicate that POPs influence pre- and postnatal development. CI - (c) 2021. The Author(s). FAU - Kronke, Anna A AU - Kronke AA AD - Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany. anna.wischnewski@fau.de. FAU - Jurkutat, Anne AU - Jurkutat A AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. FAU - Schlingmann, Maike AU - Schlingmann M AD - Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany. FAU - Poulain, Tanja AU - Poulain T AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. FAU - Nuchter, Matthias AU - Nuchter M AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. FAU - Hilbert, Anja AU - Hilbert A AD - Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. AD - Department of Psychosomatic Medicine and Psychotherapy, University of Leipzig, Leipzig, Germany. FAU - Kiviranta, Hannu AU - Kiviranta H AD - Department of Health Security, National Institute for Health and Welfare (THL), Kuopio, Finland. FAU - Korner, Antje AU - Korner A AD - Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. AD - Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. FAU - Soder, Olle AU - Soder O AD - Pediatric Endocrinology Unit, Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden. FAU - Bornehag, Carl G AU - Bornehag CG AD - Public Health Sciences, Karlstad University, Karlstad, Sweden. AD - Icahn School of Medicine at Mount Sinai, New York, NY, USA. FAU - Kiess, Wieland AU - Kiess W AD - Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), Leipzig University, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20210406 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (Environmental Pollutants) RN - 0 (Thyroid Hormones) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Child MH - Child Development MH - Dichlorodiphenyl Dichloroethylene/adverse effects MH - *Environmental Pollutants/adverse effects MH - Female MH - Humans MH - Infant, Newborn MH - Maternal Exposure/adverse effects MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls/adverse effects MH - Pregnancy MH - Pregnant Women MH - Thyroid Hormones MH - Weight Gain PMC - PMC8904258 COIS- The authors declare no competing interests. EDAT- 2021/04/08 06:00 MHDA- 2022/04/12 06:00 PMCR- 2021/04/06 CRDT- 2021/04/07 06:17 PHST- 2020/04/22 00:00 [received] PHST- 2021/03/03 00:00 [accepted] PHST- 2021/01/15 00:00 [revised] PHST- 2021/04/08 06:00 [pubmed] PHST- 2022/04/12 06:00 [medline] PHST- 2021/04/07 06:17 [entrez] PHST- 2021/04/06 00:00 [pmc-release] AID - 10.1038/s41390-021-01488-5 [pii] AID - 1488 [pii] AID - 10.1038/s41390-021-01488-5 [doi] PST - ppublish SO - Pediatr Res. 2022 Feb;91(3):690-698. doi: 10.1038/s41390-021-01488-5. Epub 2021 Apr 6.