PMID- 33827327
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20220224
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 81
IP  - 3
DP  - 2021 May
TI  - Bariatric surgery improves clinical outcomes and adiposity biomarkers but not 
      inflammatory cytokines SAA and MCP-1 after a six-month follow-up.
PG  - 230-236
LID - 10.1080/00365513.2021.1904278 [doi]
AB  - Obesity is a global health problem and is associated with a chronic low-grade 
      inflammatory state. Surgical obesity treatment is being increasingly common due 
      to its efficacy. From this, we evaluate the metabolic state improvement and 
      inflammation remission in patients with obesity undergoing bariatric surgery. 
      Methods: The clinical data and serum levels of leptin and adiponectin were 
      assessed in patients with obesity before and one, three and six months after 
      bariatric surgery. Also, serum amyloid A (SAA), monocyte chemoattractant 
      protein-1 (MCP-1) levels were measured during the follow-up surgery and compared 
      with a lean group of individuals. Results: Weight loss decreased body mass index 
      (BMI), comorbidities percentage, drugs use and leptin levels. Adiponectin levels 
      increased after surgery. SAA and MCP-1 showed no difference after surgery, but a 
      trend decrease for MCP-1 and a significant decrease was observed when the 
      patients with obesity were compared to the lean participants. Conclusion: 
      Bariatric surgery alters metabolic status improving obesity-related comorbidities 
      and the adiposity biomarkers leptin and adiponectin, but not inflammatory 
      cytokines SAA and MCP-1.
FAU - Bratti, Leticia de Oliveira Souza
AU  - Bratti LOS
AD  - Programa de Pos-Gaduacao em Farmacia, Centro de Ciencias da Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brasil.
FAU - do Carmo, Icaro Andrade Rodrigues
AU  - do Carmo IAR
AD  - Departamento de Analises Clinicas, Centro de Ciencias da Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Vilela, Tais Ferreira
AU  - Vilela TF
AD  - Departamento de Clinica Medica, Centro de Ciencias da Saude, Universidade Federal 
      de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Souza, Liliete Canes
AU  - Souza LC
AUID- ORCID: 0000-0002-2275-3076
AD  - Departamento de Analises Clinicas, Centro de Ciencias da Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Moraes, Ana Carolina Rabello de
AU  - Moraes ACR
AUID- ORCID: 0000-0003-1088-472X
AD  - Departamento de Analises Clinicas, Centro de Ciencias da Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brasil.
FAU - Filippin-Monteiro, Fabiola Branco
AU  - Filippin-Monteiro FB
AUID- ORCID: 0000-0003-4313-1783
AD  - Departamento de Analises Clinicas, Centro de Ciencias da Saude, Universidade 
      Federal de Santa Catarina, Florianopolis, SC, Brasil.
LA  - eng
PT  - Journal Article
DEP - 20210407
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Serum Amyloid A Protein)
SB  - IM
MH  - Adiponectin/blood
MH  - Adiposity/*physiology
MH  - Adult
MH  - *Bariatric Surgery
MH  - Biomarkers/blood
MH  - Chemokine CCL2/*blood
MH  - Comorbidity
MH  - Female
MH  - Follow-Up Studies
MH  - Gastric Bypass
MH  - Humans
MH  - Inflammation/*blood/etiology
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/blood/epidemiology/surgery
MH  - Serum Amyloid A Protein/*analysis
MH  - Young Adult
OTO - NOTNLM
OT  - MCP-1
OT  - Morbid obesity
OT  - SAA
OT  - adiponectin
OT  - bariatric surgery
OT  - leptin
OT  - weight-related comorbidities
EDAT- 2021/04/09 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/04/08 05:28
PHST- 2021/04/09 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/04/08 05:28 [entrez]
AID - 10.1080/00365513.2021.1904278 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2021 May;81(3):230-236. doi: 
      10.1080/00365513.2021.1904278. Epub 2021 Apr 7.