PMID- 33828991
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210409
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 11
DP  - 2021
TI  - Comparative Study on Iron Content Detection by Energy Spectral CT and MRI in MDS 
      Patients.
PG  - 646946
LID - 10.3389/fonc.2021.646946 [doi]
LID - 646946
AB  - Objective: The purpose of this study was to identify the difference between dual 
      energy spectral computed tomography (DECT) and magnetic resonance imaging (MRI) 
      used to detect liver/cardiac iron content in Myelodysplastic syndrome (MDS) 
      patients with differently adjusted serum ferritin (ASF) levels. Method: Liver and 
      cardiac iron content were detected by DECT and MRI. Patients were divided into 
      different subgroups according to the level of ASF. The receiver operating 
      characteristic curve (ROC) analysis was applied in each subgroup. The correlation 
      between iron content detected by DECT/MRI and ASF was analyzed in each subgroup. 
      Result: ROC curves showed that liver virtual iron content (LVIC) Az was 
      significantly less than liver iron concentration (LIC) Az in the subgroup with 
      ASF < 1,000 ng/ml. There was no significant difference between LVIC Az and LIC Az 
      in the subgroup with 1,000 </= ASF < 2,500 ng/ml and 2,500 </= ASF < 5,000 ng/ml. 
      LVIC Az was significantly higher than LIC Az in the subgroup with ASF <5,000 and 
      5,000 </= ASF ng/ml. In patients undergoing DECT and MRI examination on the same 
      day, ASF was significantly correlated with LVIC, whereas no significant 
      correlation was observed between ASF and LIC. After removing the data of ASF > 
      5,000 mg/L in LIC, LIC became correlated with ASF. There was no significant 
      difference between the subgroup with 2,500 </= ASF < 5,000 ng/ml and 5,000 ng/ml </= 
      ASF in LIC expression. Furthermore, both LIC and liver VIC had significant 
      correlations with ASF in patients with ASF < 2,500 ng/ml, while LVIC was still 
      correlated with ASF, LIC was not correlated with ASF in patients with 2,500 ng/ml 
      </= ASF. Moreover, neither cardiac VIC nor myocardial iron content (MIC) were 
      correlated with ASF in these subgroups. Conclusion: MRI and DECT were 
      complementary to each other in liver iron detection. In MDS patients with high 
      iron content, such as ASF >/= 5,000 ng/ml, DECT was more reliable than the MRI in 
      the assessment of iron content. But in patients with low iron content, such as 
      ASF < 1,000 ng/ml, MRI is more reliable than DECT. Therefore, for the sake of 
      more accurately evaluating the iron content, the appropriate detection method can 
      be selected according to ASF.
CI  - Copyright (c) 2021 Zhang, Xiao, Li, Song, Zhao, Han, Li, Guo, Zhao and Chang.
FAU - Zhang, Yao
AU  - Zhang Y
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Xiao, Chao
AU  - Xiao C
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Li, Jing
AU  - Li J
AD  - Department of Radiology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Song, Lu-Xi
AU  - Song LX
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Zhao, You-Shan
AU  - Zhao YS
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Han, Shuang
AU  - Han S
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Li, Zhao-Wei
AU  - Li ZW
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Guo, Cha
AU  - Guo C
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
FAU - Zhao, Jun-Gong
AU  - Zhao JG
AD  - Department of Radiology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong 
      University, Shanghai, China.
FAU - Chang, Chun-Kang
AU  - Chang CK
AD  - Department of Hematology, Sixth People's Hospital Affiliated to Shanghai Jiao 
      Tong University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20210322
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC8019931
OTO - NOTNLM
OT  - ASF
OT  - DECT
OT  - MDS
OT  - MRI
OT  - iron overload
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/04/09 06:00
MHDA- 2021/04/09 06:01
PMCR- 2021/01/01
CRDT- 2021/04/08 06:31
PHST- 2020/12/28 00:00 [received]
PHST- 2021/02/22 00:00 [accepted]
PHST- 2021/04/08 06:31 [entrez]
PHST- 2021/04/09 06:00 [pubmed]
PHST- 2021/04/09 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2021.646946 [doi]
PST - epublish
SO  - Front Oncol. 2021 Mar 22;11:646946. doi: 10.3389/fonc.2021.646946. eCollection 
      2021.