PMID- 33829964
OWN - NLM
STAT- MEDLINE
DCOM- 20210924
LR  - 20210924
IS  - 1793-6853 (Electronic)
IS  - 0192-415X (Linking)
VI  - 49
IP  - 4
DP  - 2021
TI  - Panax notoginseng Saponins Modulate the Inflammatory Response and Improve 
      IBD-Like Symptoms via TLR/NF-[Formula: see text]B and MAPK Signaling Pathways.
PG  - 925-939
LID - 10.1142/S0192415X21500440 [doi]
AB  - Panax notoginseng saponins (PNS) are the main active ingredients of Panax 
      notoginseng (Burk) F. H. Chen, which are used as traditional Chinese medicine for 
      thousands of years and have various clinical effects, including 
      anti-inflammation, anti-oxidation, and cardiovascular protection. Inflammatory 
      bowel disease (IBD) is a complex gastrointestinal inflammatory disease that 
      cannot be cured completely nowadays. The anti-inflammatory and protective effects 
      of PNS were analyzed in vitro and in dextran sulfate sodium (DSS)-induced colitis 
      mouse model. PNS inhibited the release of nitric oxide (NO), tumor necrosis 
      factor-[Formula: see text] (TNF-[Formula: see text], interleukin-6 (IL-6), and 
      monocyte chemoattractant protein-1 (MCP-1) in Pam3CSK4-induced RAW 264.7 
      macrophages. In the animal study, compared with DSS-induced mice, PNS reduced the 
      expression of pro-inflammatory cytokines (TNF-[Formula: see text], IL-6, and 
      MCP-1) in the colon tissues. Furthermore, PNS treatment led to a remarkable 
      reduction in the activation of the inhibitor of nuclear factor kappa-B kinase 
      [Formula: see text]/[Formula: see text] (IKK[Formula: see text]/[Formula: see 
      text], I[Formula: see text]B[Formula: see text] and p65 induced by DSS. On the 
      other hand, PNS inhibited the phosphorylation of c-Jun N-terminal kinase (JNK), 
      p38, and extracellular regulated protein kinase 1/2 (ERK1/2). Taken together, our 
      results suggested that PNS conferred profound protection for colitis mice through 
      the downregulation of mitogen-activated protein kinase (MAPK) and NF-[Formula: 
      see text]B signaling pathways, which were associated with reducing inflammatory 
      responses, alleviating tissue damage, and maintaining of intestinal integrity and 
      functionality.
FAU - Luo, Hua
AU  - Luo H
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Vong, Chi Teng
AU  - Vong CT
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Tan, Dechao
AU  - Tan D
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Zhang, Jinming
AU  - Zhang J
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      610000, P. R. China.
FAU - Yu, Hua
AU  - Yu H
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Yang, Lin
AU  - Yang L
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Zhang, Chen
AU  - Zhang C
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 
      610000, P. R. China.
FAU - Luo, Chun
AU  - Luo C
AD  - The First Affiliated Hospital of Guangxi Medical University, Guangxi 530000, P. 
      R. China.
FAU - Zhong, Zhangfeng
AU  - Zhong Z
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
FAU - Wang, Yitao
AU  - Wang Y
AD  - Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research 
      in Chinese Medicine, University of Macau, Macao 999078, P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20210407
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
RN  - 0 (NF-kappa B)
RN  - 0 (Saponins)
RN  - 0 (Toll-Like Receptors)
RN  - EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Disease Models, Animal
MH  - Inflammation/*drug therapy
MH  - Irritable Bowel Syndrome/*drug therapy
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mitogen-Activated Protein Kinase Kinases/*metabolism
MH  - NF-kappa B/*metabolism
MH  - *Panax notoginseng
MH  - RAW 264.7 Cells
MH  - Saponins/*pharmacology
MH  - Toll-Like Receptors/*metabolism
OTO - NOTNLM
OT  - Dextran Sulfate Sodium
OT  - Inflammatory Bowel Disease
OT  - MAPK
OT  - NF-[Formula: see text]B Signaling Pathways
OT  - Panax notoginseng Saponins
EDAT- 2021/04/09 06:00
MHDA- 2021/09/25 06:00
CRDT- 2021/04/08 12:24
PHST- 2021/04/09 06:00 [pubmed]
PHST- 2021/09/25 06:00 [medline]
PHST- 2021/04/08 12:24 [entrez]
AID - 10.1142/S0192415X21500440 [doi]
PST - ppublish
SO  - Am J Chin Med. 2021;49(4):925-939. doi: 10.1142/S0192415X21500440. Epub 2021 Apr 
      7.