PMID- 33831864
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220531
IS  - 1423-0275 (Electronic)
IS  - 0301-1569 (Linking)
VI  - 83
IP  - 6
DP  - 2021
TI  - Long Noncoding RNA NEAT1: A Potential Biomarker in the Progression of Laryngeal 
      Squamous Cell Carcinoma.
PG  - 464-470
LID - 10.1159/000515228 [doi]
AB  - INTRODUCTION: Laryngeal squamous cell carcinoma (LSCC) is diverse in its natural 
      history and responsiveness to treatments. There is an urgent need to generate 
      candidate biomarkers for the stratification and individualization of treatment to 
      avoid overtreatment or inadequate treatment. Long noncoding RNA nuclear 
      paraspeckle assembly transcript 1 (NEAT1) has been identified as an oncogenic 
      gene in multiple human tumors entitles, and dysregulation of NEAT1 was tightly 
      linked to carcinogenesis and cancer progression. METHODS: One hundred two 
      paraffin samples of LSCC patients were collected. Furthermore, in situ 
      hybridization (ISH), Kaplan-Meier, and MTT were used to analyze the relationship 
      between NEAT1 and the progress of LSCC. RESULTS: In this study, ISH revealed that 
      NEAT1 was strongly expressed in the nucleus. The increased expression of NEAT1 
      was correlated with T grade, neck nodal metastasis, clinical stage, drinking 
      history, or smoking history of LSCC. The Kaplan-Meier analysis indicated that 
      patients with higher NEAT1 expression had a worse overall survival in LSCC 
      patients. In addition, NEAT1 knockdown significantly inhibited the growth of LSCC 
      cells. CONCLUSION: Together, these results suggested that NEAT1 involved in the 
      progress of LSCC and might act as a tumor oncogenic gene. This study provides a 
      potential new marker and target for gene therapy in the treatment of LSCC.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Wang, Peng
AU  - Wang P
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, 150086, Harbin, China.
FAU - Li, Qiu-Ying
AU  - Li QY
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, 150086, Harbin, China.
FAU - Sun, Ya-Nan
AU  - Sun YN
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, 150086, Harbin, China.
FAU - Wang, Jing-Ting
AU  - Wang JT
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, 150086, Harbin, China.
FAU - Liu, Ming
AU  - Liu M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated 
      Hospital, Harbin Medical University, 150086, Harbin, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210408
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (NEAT1 long non-coding RNA, human)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Biomarkers, Tumor/genetics
MH  - Cell Proliferation
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Laryngeal Neoplasms/pathology
MH  - Prognosis
MH  - *RNA, Long Noncoding/genetics
MH  - *Squamous Cell Carcinoma of Head and Neck/genetics
OTO - NOTNLM
OT  - Laryngeal squamous cell cancer
OT  - Prognosis
OT  - lncRNA NEAT1
EDAT- 2021/04/09 06:00
MHDA- 2022/03/01 06:00
CRDT- 2021/04/08 20:34
PHST- 2020/05/06 00:00 [received]
PHST- 2021/02/12 00:00 [accepted]
PHST- 2021/04/09 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/04/08 20:34 [entrez]
AID - 000515228 [pii]
AID - 10.1159/000515228 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 2021;83(6):464-470. doi: 10.1159/000515228. 
      Epub 2021 Apr 8.