PMID- 33832303
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 2224-5839 (Electronic)
IS  - 2224-5820 (Linking)
VI  - 10
IP  - 12
DP  - 2021 Dec
TI  - Efficacy and safety of traditional Chinese medicine on treating oligomenorrhea: a 
      systematic review and meta-analysis.
PG  - 12955-12968
LID - 10.21037/apm-20-825 [doi]
AB  - BACKGROUND: Oligomenorrhea is one of the most frequent gynecologic complaints 
      that interferes with women's life quality. Treatment using traditional Chinese 
      medicine (TCM) is a preferred alternative therapy for oligomenorrhea. However, 
      systematic reviews (SRs) evaluating the efficacy of TCM treatments for 
      oligomenorrhea remain absent. The present SR and meta-analysis aimed to evaluate 
      the efficacy and safety of TCM treatment for oligomenorrhea. METHODS: Randomized 
      controlled trials (RCTs) published in English and Chinese were retrieved by 
      searching in the databases in October 2019, including PubMed, Cochrane Library, 
      EMBASE, Sinomed, CNKI, VIP, and WanFang databases. Quantitative analyses and 
      quality assessments were then conducted based on abstracted data. This study 
      protocol is registered PROSPERO, number CRD42018095660. RESULTS: A total of 26 
      eligible RCTs involving 2,389 patients were included in our analysis. Overall, we 
      observed an effect of increasing menstrual blood volumes owing to using TCM 
      treatments plus bio-medicine (BM) (n=649; MD, 12.05; 95% CI: 5.23 to 18.87; 
      P<0.00001; I2=96%). Besides, TCM combined with BM yielded a significant 
      prolongation in menstrual periods (MD, 1.20; 95% CI: 0.78 to 1.62; P<0.00001; 
      I2=76%), and had potential improvements on enhancing effectiveness rates, 
      increasing endometrial thickness, and raising the levels of estradiol (E2) and 
      progesterone (P). Concerning adverse events (AEs), no significant difference was 
      found in either group. The quality of evidence was relatively low. CONCLUSIONS: 
      This study seems to support the potential effect of TCM on treating 
      oligomenorrhea. However, the relatively low quality of prior studies calls for 
      future RCTs to further assess the efficacy of TCM on treating oligomenorrhea 
      using rigorous designs.
FAU - Li, Yannan
AU  - Li Y
AD  - Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 
      China; School of Chinese Medicine, Shandong University of Traditional Chinese 
      Medicine, Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Zhao, Guozhen
AU  - Zhao G
AD  - Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 
      China; Department of Emergency Medicine, Beijing Hospital of Traditional Chinese 
      Medicine, Capital Medical University, Beijing, China.
FAU - Shi, Wei
AU  - Shi W
AD  - Department of Gynecology, Affiliated Hospital of Shandong University of Chinese 
      Medicine, Jinan, China.
FAU - Zhang, Yin
AU  - Zhang Y
AD  - Insititue of Basic Research in Clinical Medicine, China Academy of Chinese 
      Medical Sciences, Beijing, China.
FAU - Diao, Hanlin
AU  - Diao H
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Ding, Nan
AU  - Ding N
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Li, Panpan
AU  - Li P
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Zhang, Fang
AU  - Zhang F
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Yang, Lei
AU  - Yang L
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Sun, Mengyao
AU  - Sun M
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Yu, Hang
AU  - Yu H
AD  - School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, 
      Jinan, China; Department of Gynecology, Affiliated Hospital of Shandong 
      University of Chinese Medicine, Jinan, China.
FAU - Li, Bo
AU  - Li B
AD  - Clinical Medical College of Traditional Chinese Medicine, Capital Medical 
      University, Beijing, China; Beijing Institute of Traditional Chinese Medicine, 
      Beijing, China.
FAU - Xu, Li
AU  - Xu L
AD  - Department of Traditional Chinese Medicine, Shandong Provincial Hospital 
      Affiliated to Shandong University, Jinan, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210324
PL  - China
TA  - Ann Palliat Med
JT  - Annals of palliative medicine
JID - 101585484
SB  - IM
MH  - Female
MH  - Humans
MH  - *Medicine, Chinese Traditional
MH  - *Oligomenorrhea
MH  - Quality of Life
OTO - NOTNLM
OT  - Chinese medicine therapy
OT  - meta-analysis
OT  - oligomenorrhea
OT  - randomized controlled clinical trial
OT  - systematic evaluation
EDAT- 2021/04/10 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/04/09 05:24
PHST- 2020/04/07 00:00 [received]
PHST- 2020/12/01 00:00 [accepted]
PHST- 2021/04/10 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/04/09 05:24 [entrez]
AID - apm-20-825 [pii]
AID - 10.21037/apm-20-825 [doi]
PST - ppublish
SO  - Ann Palliat Med. 2021 Dec;10(12):12955-12968. doi: 10.21037/apm-20-825. Epub 2021 
      Mar 24.