PMID- 33833794
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210410
IS  - 1687-6121 (Print)
IS  - 1687-630X (Electronic)
IS  - 1687-6121 (Linking)
VI  - 2021
DP  - 2021
TI  - Prognostic Value of Inflammatory and Tumour Markers in Small-Duct Subtype 
      Intrahepatic Cholangiocarcinoma after Curative-Intent Resection.
PG  - 6616062
LID - 10.1155/2021/6616062 [doi]
LID - 6616062
AB  - Intrahepatic cholangiocarcinoma (ICC) is characterised by heterogeneity, and it 
      can be subdivided into small-duct and large-duct types. Inflammatory and tumour 
      markers could effectively predict prognosis in many cancers, but no similar 
      studies have been conducted in the histological subtypes of ICC. A total of 102 
      and 72 patients with ICC undergoing curative-intent resection were 
      retrospectively subclassified into large-duct and small-duct types by chemical 
      staining, respectively. The prognostic value of inflammatory and tumour markers 
      was studied for the first time in histological subtypes of ICC by using a Cox 
      regression model. A novel predictor named prognostic inflammatory index (PII) was 
      proposed and defined as neutrophil x monocyte/lymphocyte count (10(9)/L). 
      Survival analysis showed that PII, neutrophil-to-lymphocyte ratio (NLR), 
      lymphocyte-to-monocyte ratio (LMR), carcinoembryonic antigen (CEA), carbohydrate 
      antigen 19-9 (CA19-9), CA242, and ferritin were all predictors of DFS and OS in 
      patients with ICC (P < 0.040). Subgroup analysis showed that PII, CA19-9, and 
      ferritin were risk predictors of disease-free survival (DFS) and overall survival 
      (OS) in small-duct type ICC (P < 0.015). In addition, in small-duct type ICC, NLR 
      and LMR were correlated with OS (P < 0.025), whilst CEA and CA242 were correlated 
      with DFS (P </= 0.010). In conclusion, PII is a convenient and efficient 
      inflammatory predictor of DFS and OS in ICCs and their small-duct type. NLR and 
      LMR, rather than platelet-to-lymphocyte ratio, were correlated with OS in 
      small-duct type ICC. In addition, ferritin may be a supplement to CA19-9 in 
      stratifying the survival outcome of patients with small-duct type ICC.
CI  - Copyright (c) 2021 Bingqi Ma et al.
FAU - Ma, Bingqi
AU  - Ma B
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Meng, Huijuan
AU  - Meng H
AD  - Department of Dermatology, Affiliated Hospital of Weifang Medical University, 
      Weifang 261031, China.
FAU - Shen, An
AU  - Shen A
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Ma, Yuwen
AU  - Ma Y
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Zhao, Dianpeng
AU  - Zhao D
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Liu, Guiling
AU  - Liu G
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Zheng, Shujuan
AU  - Zheng S
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
FAU - Tian, Ye
AU  - Tian Y
AD  - Tianjin Medical University Cancer Institute and Hospital, National Clinical 
      Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, 
      Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, China.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute 
      and Hospital, National Clinical Research Center for Cancer, Key Laboratory of 
      Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for 
      Cancer, Tianjin 300060, China.
FAU - Li, Qiang
AU  - Li Q
AD  - Department of Hepatobiliary Surgery, Tianjin Medical University Cancer Institute 
      and Hospital, National Clinical Research Center for Cancer, Key Laboratory of 
      Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for 
      Cancer, Tianjin 300060, China.
FAU - Li, Shiping
AU  - Li S
AUID- ORCID: 0000-0001-9144-0180
AD  - Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang 
      Medical University, Weifang 261031, China.
LA  - eng
PT  - Journal Article
DEP - 20210326
PL  - Egypt
TA  - Gastroenterol Res Pract
JT  - Gastroenterology research and practice
JID - 101475557
PMC - PMC8018878
COIS- The authors declare that they have no competing interests.
EDAT- 2021/04/10 06:00
MHDA- 2021/04/10 06:01
PMCR- 2021/03/26
CRDT- 2021/04/09 06:26
PHST- 2020/11/10 00:00 [received]
PHST- 2021/03/16 00:00 [revised]
PHST- 2021/03/22 00:00 [accepted]
PHST- 2021/04/09 06:26 [entrez]
PHST- 2021/04/10 06:00 [pubmed]
PHST- 2021/04/10 06:01 [medline]
PHST- 2021/03/26 00:00 [pmc-release]
AID - 10.1155/2021/6616062 [doi]
PST - epublish
SO  - Gastroenterol Res Pract. 2021 Mar 26;2021:6616062. doi: 10.1155/2021/6616062. 
      eCollection 2021.