PMID- 33837779
OWN - NLM
STAT- MEDLINE
DCOM- 20211116
LR  - 20211116
IS  - 1945-7197 (Electronic)
IS  - 0021-972X (Linking)
VI  - 106
IP  - 10
DP  - 2021 Sep 27
TI  - Predictive Value of Serum Lipid for Intravenous Immunoglobulin Resistance and 
      Coronary Artery Lesion in Kawasaki Disease.
PG  - e4210-e4220
LID - 10.1210/clinem/dgab230 [doi]
AB  - CONTEXT: Intravenous immunoglobulin (IVIG) resistance and coronary artery lesions 
      (CALs) prediction are pivotal topic of interests in Kawasaki disease (KD). 
      However, data on the predictive value of lipid profile for both IVIG resistance 
      and CALs are limited. PURPOSE: To investigate the predictive validity of lipid 
      profile for IVIG resistance and CALs in KD. DESIGN: Prospective cohort study. 
      SETTING: West China Second University Hospital. PATIENTS: 363 KD patients were 
      divided into the initial IVIG-resistant group and initial IVIG-responsive group; 
      repeated IVIG-resistant group and repeated IVIG-responsive group; CAL+ group and 
      CAL- group. MAIN OUTCOME MEASURES: Validity of lipid profile in predicting IVIG 
      resistance and CALs. RESULTS: Triglycerides were significantly higher whereas 
      total cholesterol (TC), high-densisty lipoprotein cholesterol (HDL-C), 
      low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A (Apo A) were 
      significantly lower in initial IVIG-resistant subjects, with cut-off values of 
      1.625 mmol/L, 3.255 mmol/L, 0.475 mmol/L, 1.965 mmol/L, and 0.665 g/L, yielding 
      sensitivities of 52%, 70%, 52%, 61%, and 50% and specificities of 68%, 53%, 78%, 
      71%, and 81%, respectively. TC, LDL-C, and Apo A levels were significantly lower 
      in repeated IVIG-resistant subjects, with cut-off values of 3.20 mmol/L, 1.78 
      mmol/L, and 0.605 g/L, producing sensitivities of 91%, 70%, and 57% and 
      specificities of 55%, 67%, and 70%, respectively. Apo A level was significantly 
      lower in the CAL+ group, with cut-off value of 0.805 g/L, yielding sensitivity of 
      66% and specificity of 54%. CONCLUSIONS: Lipid profiles were significantly 
      dysregulated in KD patients suffering IVIG resistance and CALs. Some of them, 
      such as LDL-C and Apo A, could serve as complementary laboratory markers for 
      predicting both IVIG resistance and CALs.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Endocrine Society. All rights reserved. For permissions, please e-mail: 
      journals.permissions@oup.com.
FAU - Shao, Shuran
AU  - Shao S
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - West China Medical School of Sichuan University, Chengdu, Sichuan, China.
FAU - Zhou, Kaiyu
AU  - Zhou K
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
AD  - Key Laboratory of Development and Diseases of Women and Children of Sichuan 
      Province, West China Second University Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Liu, Xiaoliang
AU  - Liu X
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Liu, Lei
AU  - Liu L
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - West China Medical School of Sichuan University, Chengdu, Sichuan, China.
FAU - Wu, Mei
AU  - Wu M
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
FAU - Deng, Yuxin
AU  - Deng Y
AD  - Wenzhou Medical University, Wenzhou, Zhejiang, China.
FAU - Duan, Hongyu
AU  - Duan H
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
AD  - Key Laboratory of Development and Diseases of Women and Children of Sichuan 
      Province, West China Second University Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Li, Yifei
AU  - Li Y
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
AD  - Key Laboratory of Development and Diseases of Women and Children of Sichuan 
      Province, West China Second University Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Hua, Yimin
AU  - Hua Y
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
AD  - Key Laboratory of Development and Diseases of Women and Children of Sichuan 
      Province, West China Second University Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
FAU - Wang, Chuan
AU  - Wang C
AUID- ORCID: 0000-0001-5165-8273
AD  - Department of Pediatric Cardiology, West China Second University Hospital, 
      Sichuan University, Chengdu, Sichuan, China.
AD  - The Cardiac development and early intervention unit, West China Institute of 
      Women and Children's Health, West China Second University Hospital, Sichuan 
      University, Chengdu, Sichuan, China.
AD  - Key Laboratory of Birth Defects and Related Diseases of Women and Children 
      (Sichuan University), Ministry of Education Chengdu, Sichuan, China.
AD  - Key Laboratory of Development and Diseases of Women and Children of Sichuan 
      Province, West China Second University Hospital, Sichuan University, Chengdu, 
      Sichuan, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Lipids)
SB  - IM
MH  - Biomarkers/blood
MH  - Child, Preschool
MH  - China
MH  - Coronary Artery Disease/*diagnosis/etiology
MH  - Coronary Vessels/pathology
MH  - Drug Resistance/*immunology
MH  - Female
MH  - Humans
MH  - *Immunoglobulins, Intravenous
MH  - Infant
MH  - Lipids/*blood
MH  - Male
MH  - Mucocutaneous Lymph Node Syndrome/*blood/complications/drug therapy
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reference Values
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Kawasaki disease
OT  - coronary artery lesions
OT  - immunoglobulin resistance
OT  - lipid profile
OT  - prediction
EDAT- 2021/04/11 06:00
MHDA- 2021/11/17 06:00
CRDT- 2021/04/10 12:07
PHST- 2020/09/23 00:00 [received]
PHST- 2021/04/11 06:00 [pubmed]
PHST- 2021/11/17 06:00 [medline]
PHST- 2021/04/10 12:07 [entrez]
AID - 6219846 [pii]
AID - 10.1210/clinem/dgab230 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2021 Sep 27;106(10):e4210-e4220. doi: 
      10.1210/clinem/dgab230.