PMID- 33838293
OWN - NLM
STAT- MEDLINE
DCOM- 20220120
LR  - 20220120
IS  - 1096-1186 (Electronic)
IS  - 1043-6618 (Linking)
VI  - 168
DP  - 2021 Jun
TI  - Role of dietary modifications in the management of type 2 diabetic complications.
PG  - 105602
LID - S1043-6618(21)00186-9 [pii]
LID - 10.1016/j.phrs.2021.105602 [doi]
AB  - Diabetes is a chronic metabolic disorder with a high rate of morbidity and 
      mortality. Insufficient insulin secretion and insulin action are two major causes 
      for the development of diabetes, which is characterized by a persistent increase 
      in blood glucose level. Diet and sedentary life style play pivotal role in 
      development of vascular complications in type 2 diabetes. Dietary modification is 
      associated with a reprogramming of nutrient intake, which are proven to be 
      effective for the management of diabetes and associated complications. Dietary 
      modifications modulate various molecular key players linked with the functions of 
      nutrient signalling, regulation of autophagy, and energy metabolism. It activates 
      silent mating type information regulation 2 homolog1 (SIRT1) and AMP-activated 
      protein kinase (AMPK). AMPK mainly acts as an energy sensor and inhibits 
      autophagy repressor Mammalian target of rapamycin (mTOR) under nutritional 
      deprivation. Under calorie restriction (CR), SIRT1 gets activated directly or 
      indirectly and plays a central role in autophagy via the regulation of protein 
      acetylation. Dietary modification is also effective in controlling inflammation 
      and apoptosis by decreasing the level of pro-inflammatory cytokines like nuclear 
      factor kappa- beta (NF-kbeta), tissue growth factor-beta (TGF-beta), tissue necrosis 
      factor-alpha (TNF-alpha) and interleukin-6 (IL-6). It also improves glucose 
      homeostasis and insulin secretion through beta cell regeneration. This indicates 
      calorie intake plays a crucial role in the pathogenesis of type 2 
      diabetes-associated complications. The present review, emphasizes the role of 
      dietary modifications in diabetes and associated complications.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Oza, Manisha J
AU  - Oza MJ
AD  - SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W), Mumbai 400056, 
      India.
FAU - Laddha, Ankit P
AU  - Laddha AP
AD  - Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's 
      NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India.
FAU - Gaikwad, Anil Bhanudas
AU  - Gaikwad AB
AD  - Laboratory of Molecular Pharmacology, Department of Pharmacy, Birla Institute of 
      Technology and Science Pilani, Pilani Campus, Rajasthan 333031, India.
FAU - Mulay, Shrikant R
AU  - Mulay SR
AD  - Division of Pharmacology, CSIR-Central Drug Research Institute, Lucknow 226031, 
      India.
FAU - Kulkarni, Yogesh A
AU  - Kulkarni YA
AD  - Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's 
      NMIMS, V.L. Mehta Road, Vile Parle (W), Mumbai 400056, India. Electronic address: 
      yogeshkulkarni101@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210408
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
SB  - IM
MH  - Animals
MH  - Caloric Restriction
MH  - Diabetes Complications/*diet therapy
MH  - Diabetes Mellitus, Type 2/complications/*diet therapy
MH  - Diabetic Cardiomyopathies/diet therapy
MH  - Diabetic Nephropathies/diet therapy
MH  - Diabetic Neuropathies/diet therapy
MH  - Diabetic Retinopathy/diet therapy
MH  - Humans
OTO - NOTNLM
OT  - Calorie restriction
OT  - Diabetic cardiomyopathy
OT  - Diabetic nephropathy
OT  - Diabetic neuropathy
OT  - Dietary modification
EDAT- 2021/04/11 06:00
MHDA- 2022/01/21 06:00
CRDT- 2021/04/10 20:09
PHST- 2021/02/24 00:00 [received]
PHST- 2021/03/31 00:00 [revised]
PHST- 2021/04/02 00:00 [accepted]
PHST- 2021/04/11 06:00 [pubmed]
PHST- 2022/01/21 06:00 [medline]
PHST- 2021/04/10 20:09 [entrez]
AID - S1043-6618(21)00186-9 [pii]
AID - 10.1016/j.phrs.2021.105602 [doi]
PST - ppublish
SO  - Pharmacol Res. 2021 Jun;168:105602. doi: 10.1016/j.phrs.2021.105602. Epub 2021 
      Apr 8.