PMID- 33838996
OWN - NLM
STAT- MEDLINE
DCOM- 20210628
LR  - 20210628
IS  - 1590-3729 (Electronic)
IS  - 0939-4753 (Linking)
VI  - 31
IP  - 6
DP  - 2021 Jun 7
TI  - Effect of dietary sodium restriction on blood pressure in type 2 diabetes: A 
      meta-analysis of randomized controlled trials.
PG  - 1653-1661
LID - S0939-4753(21)00090-9 [pii]
LID - 10.1016/j.numecd.2021.02.019 [doi]
AB  - AIMS: Although current guidelines recommend reduction of salt intake in patients 
      with diabetes, the benefits of reducing salt intake in people with type 2 
      diabetes mellitus (T2DM) lack clear evidence. Therefore, we performed a 
      meta-analysis of available randomized controlled trials (RCTs) of sodium 
      restriction and blood pressure (BP) in patients with T2DM. DATA SYNTHESIS: We 
      performed a systematic search of the online databases that evaluated the effect 
      of dietary sodium restriction on BP in patients with T2DM. Sodium intake was 
      expressed by 24 h urinary sodium excretion (UNaV). Q statistics and I(2) were 
      used to explore between-study heterogeneity. A random-effects model was used in 
      the presence of significant heterogeneity; otherwise, a fixed-effects model was 
      applied. Eight RCTs with 10 trials (7 cross-over and 3 parallel designs) were 
      included in the meta-analysis. Compared with ordinary sodium intake, dietary 
      sodium restriction significantly decreased UNaV (weighted mean difference, WMD: 
      -38.430 mmol/24 h; 95% CI: -41.665 mmol/24 h to -35.194 mmol/24 h). Sodium 
      restriction significantly lowered systolic BP (WMD: -5.574 mm Hg; 95% CI: -8.314 
      to -2.834 mm Hg; I(2) = 0.0%) and diastolic BP (WMD: -1.675 mm Hg; 95% CI: -3.199 
      to -0.150 mm Hg; I(2) = 0.0%) with low heterogeneity among the studies. No 
      publication bias was found from Begg's and Egger's tests. CONCLUSIONS: Sodium 
      restriction significantly reduces SBP and DBP in patients with T2DM.
CI  - Copyright (c) 2021 The Italian Diabetes Society, the Italian Society for the Study 
      of Atherosclerosis, the Italian Society of Human Nutrition and the Department of 
      Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. 
      All rights reserved.
FAU - Ren, Jingyi
AU  - Ren J
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, China.
FAU - Qin, Liqiang
AU  - Qin L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Soochow 
      University, Suzhou, China.
FAU - Li, Xiang
AU  - Li X
AD  - Undergraduate of College of Public Health, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Zhao, Ran
AU  - Zhao R
AD  - Undergraduate of College of Basic Medicine, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Wu, Zhixing
AU  - Wu Z
AD  - Undergraduate of College of Basic Medicine, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Ma, Yuxia
AU  - Ma Y
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical 
      University, Hebei Province Key Laboratory of Environment and Human Health, 
      Shijiazhuang, China. Electronic address: mayuxia@hebmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210226
PL  - Netherlands
TA  - Nutr Metab Cardiovasc Dis
JT  - Nutrition, metabolism, and cardiovascular diseases : NMCD
JID - 9111474
RN  - 0 (Sodium, Dietary)
SB  - IM
MH  - Aged
MH  - *Blood Pressure
MH  - Diabetes Mellitus, Type 2/diagnosis/*diet therapy/physiopathology
MH  - *Diet, Sodium-Restricted
MH  - Female
MH  - Humans
MH  - Hypertension/diagnosis/*diet therapy/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Randomized Controlled Trials as Topic
MH  - Sodium, Dietary/*adverse effects
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Blood pressure
OT  - Dietary salt restriction
OT  - Meta-analysis
OT  - Randomized controlled trial
OT  - Type 2 diabetes
COIS- Declaration of competing interest All authors declare no conflicts of interest.
EDAT- 2021/04/12 06:00
MHDA- 2021/06/29 06:00
CRDT- 2021/04/11 20:25
PHST- 2020/09/22 00:00 [received]
PHST- 2021/02/17 00:00 [revised]
PHST- 2021/02/19 00:00 [accepted]
PHST- 2021/04/12 06:00 [pubmed]
PHST- 2021/06/29 06:00 [medline]
PHST- 2021/04/11 20:25 [entrez]
AID - S0939-4753(21)00090-9 [pii]
AID - 10.1016/j.numecd.2021.02.019 [doi]
PST - ppublish
SO  - Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1653-1661. doi: 
      10.1016/j.numecd.2021.02.019. Epub 2021 Feb 26.