PMID- 33839551
OWN - NLM
STAT- MEDLINE
DCOM- 20210702
LR  - 20210702
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 153
DP  - 2021 Aug
TI  - Exposure to multiple metals and the risk of hypertension in adults: A prospective 
      cohort study in a local area on the Yangtze River, China.
PG  - 106538
LID - S0160-4120(21)00163-X [pii]
LID - 10.1016/j.envint.2021.106538 [doi]
AB  - BACKGROUND: Exposure to multiple metals is recognized as a common and real 
      scenario in daily life. However, limited prospective studies have assessed 
      associations between multiple metals exposure and hypertension. METHODS: In 
      total, 2625 adults in a local area on the Yangtze River were investigated at 
      baseline from 2014 to 2015 and followed up in 2019. We measured baseline urine 
      levels of 22 metals and used multivariate logistic analysis and Bayesian kernel 
      machine regression (BKMR) to explore associations between multiple metals 
      exposure and the risk of hypertension. RESULTS: A total of 385 individuals 
      (29.6%) were diagnosed with hypertension. Five metals (cadmium, copper, 
      magnesium, molybdenum and zinc) were positively associated with hypertension in 
      single-metal models. Cadmium and zinc remained significantly positive 
      associations after adjusting for these five metals, with the odds ratio (OR) in 
      the highest quartiles of 1.49 (95% CI: 1.01, 2.21; p-trend = 0.05) and 1.60 (95% 
      CI: 1.08, 2.38; p-trend = 0.02), respectively. BKMR analysis showed a significant 
      joint effect of multiple metals on hypertension when the concentrations of five 
      metals were at or above their 55th percentile compared with their median values. 
      A potential interaction between cadmium and zinc in increasing the risk of 
      hypertension was observed with the OR(int) of 1.41 (95%CI: 1.05, 1.89). 
      CONCLUSIONS: We identified the joint effect of multiple metals on hypertension 
      and observed a significant interaction between cadmium and zinc. Further cohort 
      studies are needed to clarify the health effects of multiple metals exposure in a 
      larger population.
CI  - Copyright (c) 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.
FAU - Zhong, Qi
AU  - Zhong Q
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Wu, Hua-Bing
AU  - Wu HB
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Niu, Qin-Shan
AU  - Niu QS
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Jia, Ping-Ping
AU  - Jia PP
AD  - JC School of Public Health and Primary Care, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Qin, Qi-Rong
AU  - Qin QR
AD  - Ma(,)anshan Center for Disease Control and Provention, Ma(,)anshan, Anhui, China.
FAU - Wang, Xiao-Dong
AU  - Wang XD
AD  - Yian Center for Disease Control and Provention, Tongling, Anhui, China.
FAU - He, Jia-Liu
AU  - He JL
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Yang, Wan-Jun
AU  - Yang WJ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China.
FAU - Huang, Fen
AU  - Huang F
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Anhui 
      Medical University, 81 Meishan Road, Hefei, Anhui, China. Electronic address: 
      fenh@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210409
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
SB  - IM
MH  - Adult
MH  - Bayes Theorem
MH  - China/epidemiology
MH  - Humans
MH  - *Hypertension/chemically induced/epidemiology
MH  - Prospective Studies
MH  - *Rivers
OTO - NOTNLM
OT  - BKMR analysis
OT  - Hypertension
OT  - Multiple metals
OT  - Yangtze River
EDAT- 2021/04/12 06:00
MHDA- 2021/07/03 06:00
CRDT- 2021/04/11 20:43
PHST- 2020/09/01 00:00 [received]
PHST- 2021/02/28 00:00 [revised]
PHST- 2021/03/19 00:00 [accepted]
PHST- 2021/04/12 06:00 [pubmed]
PHST- 2021/07/03 06:00 [medline]
PHST- 2021/04/11 20:43 [entrez]
AID - S0160-4120(21)00163-X [pii]
AID - 10.1016/j.envint.2021.106538 [doi]
PST - ppublish
SO  - Environ Int. 2021 Aug;153:106538. doi: 10.1016/j.envint.2021.106538. Epub 2021 
      Apr 9.