PMID- 33839729
OWN - NLM
STAT- MEDLINE
DCOM- 20210920
LR  - 20210920
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 182
IP  - 7
DP  - 2021
TI  - Relevance of Major Allergens in Weed Pollen Allergy.
PG  - 637-641
LID - 10.1159/000514719 [doi]
AB  - INTRODUCTION: Weed pollen allergy is an important and in prevalence increasing 
      cause of pollinosis in Europe and across the world. In this study we focus on the 
      value of common diagnostic tools for detection of a sensitization to mugwort and 
      English plantain, especially with regard to the clinical relevance of the 
      sensitization. METHODS: Eighty weed pollen sensitized patients (41 to mugwort and 
      39 to English plantain) were assessed retrospectively regarding their clinical 
      anamnesis, in-vivo tests (skin prick test [SPT] and allergen specific 
      provocation) and in-vitro tests (immunoglobulin E [IgE] reactivity to purified 
      natural allergen extract and specific allergen components in serum). RESULTS: 85% 
      of mugwort and 83% of English plantain sensitizations could be diagnosed by SPT 
      alone. Distinction between allergic and non-allergic patients could be made with 
      clinical challenges solely. IgE serology revealed IgE antibodies against the 
      native pollen extracts for mugwort in 98% and for English plantain in 90% of 
      patients. Detection of major allergens nArt v 1, nArt v 3 and Pla l 1 did not add 
      accuracy to the diagnosis. A vast majority of the weed pollen allergic patients 
      was sensitized to >1 allergen. Minor allergens were found to be of less 
      importance. CONCLUSION: The exact diagnosis of weed pollen allergy can be 
      challenging due to confounding components in anamnesis and diagnostic tests. 
      IgE-serology does not delineate allergic from sensitized patients. Component 
      resolved diagnostics (CRD) can confirm, but not replace, extract based diagnostic 
      methods, such as SPT, provocation tests or serology to native extracts. Hence, 
      these are the gold standard diagnostic tools in weed pollen allergy up to now.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - San Nicolo, Marion
AU  - San Nicolo M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, 
      Ludwig-Maximilians-University of Munich, Munich, Germany.
FAU - Hogerle, Catalina
AU  - Hogerle C
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, 
      Ludwig-Maximilians-University of Munich, Munich, Germany.
FAU - Gellrich, Donata
AU  - Gellrich D
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, 
      Ludwig-Maximilians-University of Munich, Munich, Germany.
FAU - Groger, Moritz
AU  - Groger M
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, 
      Ludwig-Maximilians-University of Munich, Munich, Germany.
LA  - eng
PT  - Journal Article
DEP - 20210409
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Allergens)
RN  - 0 (Antigens, Plant)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - Antigens, Plant/immunology
MH  - Humans
MH  - Immunization
MH  - Immunoglobulin E/blood/immunology
MH  - Plant Weeds/*adverse effects
MH  - Pollen/*immunology
MH  - Rhinitis, Allergic, Seasonal/diagnosis/*epidemiology/*immunology
MH  - Skin Tests
OTO - NOTNLM
OT  - Component resolved diagnostics
OT  - English plantain
OT  - Mugwort
OT  - Recombinant allergens
EDAT- 2021/04/12 06:00
MHDA- 2021/09/21 06:00
CRDT- 2021/04/11 20:49
PHST- 2021/01/11 00:00 [received]
PHST- 2021/01/25 00:00 [accepted]
PHST- 2021/04/12 06:00 [pubmed]
PHST- 2021/09/21 06:00 [medline]
PHST- 2021/04/11 20:49 [entrez]
AID - 000514719 [pii]
AID - 10.1159/000514719 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2021;182(7):637-641. doi: 10.1159/000514719. Epub 2021 
      Apr 9.