PMID- 33841009
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 1226-8453 (Print)
IS  - 2093-4947 (Electronic)
IS  - 1226-8453 (Linking)
VI  - 45
IP  - 2
DP  - 2021 Mar
TI  - Ginsenoside Rb(1) inhibits monoiodoacetate-induced osteoarthritis in 
      postmenopausal rats through prevention of cartilage degradation.
PG  - 287-294
LID - 10.1016/j.jgr.2020.01.004 [doi]
AB  - BACKGROUND: Ginsenoside Rb1 (G-Rb1), one of the major active compounds in Panax 
      ginseng, has already been shown to reduce inflammation in various diseases. 
      Osteoarthritis (OA) has traditionally been considered a degenerative disease with 
      degradation of joint articular cartilage. However, recent studies have shown the 
      association of inflammation with OA. In the present study, we investigated 
      whether Rb1 had an antiinflammatory effect on monoiodoacetate (MIA)-induced OA in 
      ovariectomized rats as a model of postmenopausal arthritis. METHODS: G-Rb1 at a 
      dosage of 3 and 10 mug/kg body weight was administered every 3 days 
      intraarticularly for a period of 4 weeks to observe antiarthritic effects. 
      Diclofenac (10 mg/kg) served as a positive control. RESULTS: The administration 
      of Rb1 significantly ameliorated OA inflammatory symptoms and reduced serum 
      levels of inflammatory cytokines. Furthermore, G-Rb1 administration considerably 
      enhanced the expression of bone morphogenetic protein-2 and collagen 2A and 
      reduced the levels of matrix metalloproteinase-13 genes, indicating a 
      chondroprotective effect of G-Rb1. G-Rb1 also significantly reduced the 
      expression of several inflammatory cytokines/chemokines (interferon gamma 
      (IFN-gamma), monocyte chemoattractant protein-1 (MCP-1)/CCL-2, interleukin [IL]-1beta, 
      and IL-6). Histological analysis demonstrated that G-Rb1 significantly attenuated 
      the pathological changes in MIA-induced OA in ovariectomized rats. Safranin O and 
      toluidine blue staining further demonstrated that G-Rb1 effectively prevented the 
      degradation of cartilage and glycosaminoglycans, respectively. CONCLUSION: 
      Overall, our results suggest that G-Rb1 exerts cartilage protective effect on 
      MIA-induced ovariectomized OA rats, by inhibiting inflammatory mediators such as 
      IL-6, IL-1beta, MCP-1/CCL-2, cyclooxygenase-2 (COX-2), and prostaglandin E(2) 
      (PGE2). These results shed a light on possible therapeutic application of G-Rb1 
      in OA.
CI  - (c) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V.
FAU - Aravinthan, Adithan
AU  - Aravinthan A
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
FAU - Hossain, Mohammad Amjad
AU  - Hossain MA
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
FAU - Kim, Bumseok
AU  - Kim B
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
FAU - Kang, Chang-Won
AU  - Kang CW
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
FAU - Kim, Nam Soo
AU  - Kim NS
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
FAU - Hwang, Ki-Chul
AU  - Hwang KC
AD  - Department of Medicine, College of Medicine, Catholic Kwandong University, 
      Gangneung, Republic of Korea.
FAU - Kim, Jong-Hoon
AU  - Kim JH
AD  - College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National 
      University, Iksan-city, Jeollabuk-Do, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20200121
PL  - Korea (South)
TA  - J Ginseng Res
JT  - Journal of ginseng research
JID - 100890690
PMC - PMC8020294
OTO - NOTNLM
OT  - Ginsenoside-Rb1
OT  - Hstological analysis
OT  - Monoiodoacetate
OT  - Osteoarthritis
OT  - Ovariectomy
COIS- None of the authors have conflicts of interest to declare.
EDAT- 2021/04/13 06:00
MHDA- 2021/04/13 06:01
PMCR- 2020/01/21
CRDT- 2021/04/12 06:14
PHST- 2019/11/19 00:00 [received]
PHST- 2019/12/23 00:00 [revised]
PHST- 2020/01/14 00:00 [accepted]
PHST- 2021/04/12 06:14 [entrez]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/04/13 06:01 [medline]
PHST- 2020/01/21 00:00 [pmc-release]
AID - S1226-8453(19)30345-8 [pii]
AID - 10.1016/j.jgr.2020.01.004 [doi]
PST - ppublish
SO  - J Ginseng Res. 2021 Mar;45(2):287-294. doi: 10.1016/j.jgr.2020.01.004. Epub 2020 
      Jan 21.