PMID- 33842599
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 5
DP  - 2021 Mar
TI  - Developing and validating a novel nomogram used a competing-risks model for 
      predicting the prognosis of primary fallopian tube carcinoma: a retrospective 
      study based on the SEER database.
PG  - 378
LID - 10.21037/atm-20-5398 [doi]
LID - 378
AB  - BACKGROUND: The current prognostic methods for primary fallopian tube carcinoma 
      (PFTC) are inadequate. This study is the first to use a competing-risks model to 
      perform an accurate analysis of the prognostic factors for PFTC cause-specific 
      death (CSD). We used the model to established a nomogram for the 3-, 5-, and 
      8-year CSD rates based on the identified prognostic factors. METHODS: This study 
      selected 1,924 patients from the SEER (Surveillance, Epidemiology, and End 
      Results) database. The cumulative incidence function (CIF) was used in univariate 
      analyses, and Gray's test was used to determine the intergroup difference in the 
      CIF. We then used the subdistribution proportional hazards model in a 
      multivariate analysis. We finally used the prognostic factors identified in the 
      analysis of the competing-risks model to construct a 3-, 5-, and 8-year CSD 
      nomogram for PFTC patients. The concordance index (C-index) and calibration plots 
      were used to evaluate the discrimination ability and consistency of the model. 
      RESULTS: The subdistribution proportional hazards model showed that age, 
      histological type, FIGO stage, and the log of the ratio between the numbers of 
      positive and negative lymph nodes (LODDS) were independent prognostic factors for 
      CSD. The 3-, 5-, and 8-year C-indexes were 0.744, 0.744, and 0.733 in the 
      training cohort, and 0.737, 0.748, and 0.721 in the validation cohort. In the 
      calibration plots, the forecast lines were very close to the reference lines. 
      CONCLUSIONS: This study is the first to analyze the prognostic factors for PFTC 
      based on a competing-risks model. This model indicates that age, histological 
      type, FIGO stage, and LODDS are significant prognostic factors affecting CSD in 
      PFTC patients. We have also constructed the first 3-, 5-, and 8-year CSD nomogram 
      for PFTC patients. This nomogram exhibits good discrimination ability and 
      accuracy and can help clinicians to provide individualized prognostic analysis 
      for PFTC patients.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Li, Chengzhuo
AU  - Li C
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Li, Junyuan
AU  - Li J
AD  - Medical Centre of Stomatology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, China.
FAU - Huang, Qiao
AU  - Huang Q
AD  - Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan 
      University, Wuhan, China.
FAU - Feng, Xiaojie
AU  - Feng X
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Zhao, Fanfan
AU  - Zhao F
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Xu, Fengshuo
AU  - Xu F
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Han, Didi
AU  - Han D
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
FAU - Lyu, Jun
AU  - Lyu J
AD  - Department of Clinical Research, The First Affiliated Hospital of Jinan 
      University, Guangzhou, China.
AD  - School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC8033332
OTO - NOTNLM
OT  - Primary fallopian tube carcinoma (PFTC)
OT  - SEER
OT  - cancer-specific death
OT  - competing risk model
OT  - nomogram
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-5398). All authors report 
      grants from National Social Science Foundation of China (grant No. 16BGL183), 
      during the conduct of the study.
EDAT- 2021/04/13 06:00
MHDA- 2021/04/13 06:01
PMCR- 2021/03/01
CRDT- 2021/04/12 06:25
PHST- 2021/04/12 06:25 [entrez]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/04/13 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - atm-09-05-378 [pii]
AID - 10.21037/atm-20-5398 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Mar;9(5):378. doi: 10.21037/atm-20-5398.