PMID- 33842662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210413
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 9
IP  - 5
DP  - 2021 Mar
TI  - Pruritus in autoimmune connective tissue diseases.
PG  - 441
LID - 10.21037/atm-20-4894 [doi]
LID - 441
AB  - Pruritus is one of the most common and bothersome symptoms of skin disorders, and 
      its clinical characteristics and related pathomechanisms have been well described 
      in certain dermatologic conditions, such as atopic dermatitis and urticaria. 
      Although pruritus is believed to be as common in cutaneous autoimmune connective 
      tissue diseases (ACTDs) as in other inflammatory skin disorders, its true 
      characteristics have not been elucidated either qualitatively or quantitatively. 
      Pruritus is present in ACTDs with various prevalence rates, characteristics, and 
      mechanisms depending on the disease types. Pruritus most frequently and severely 
      affects the patients with dermatomyositis, in which itch is strongly correlated 
      with disease activity and severity, thus increased itch could also indicate a 
      disease flare. Patients with other ACTDs, including lupus erythematosus (LE), 
      Sjogren syndrome (SS), morphea, and systemic sclerosis (SSc), also suffer from 
      their fair share of pruritus. Unfortunately, the currently available treatments 
      for ACTDs seem to have only limited and unsatisfactory effects to control 
      pruritus. The extensive impact of pruritus on the patients' quality of life (QOL) 
      and functioning warrants more targeted and individualized approaches against 
      pruritus in ACTDs. This review will address the prevalence, suggested 
      pathogenesis based on currently available evidences, and potential treatment 
      options of pruritus in various ACTDs of the skin.
CI  - 2021 Annals of Translational Medicine. All rights reserved.
FAU - Kim, Hee Joo
AU  - Kim HJ
AD  - Department of Dermatology, Gachon Gil Medical Center, Gachon University College 
      of Medicine, Incheon, South Korea.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC8033328
OTO - NOTNLM
OT  - Autoimmune connective tissue disease (ACTD)
OT  - itch
OT  - pathogenesis
OT  - pruritus
COIS- Conflicts of Interest: The author has completed the ICMJE uniform disclosure form 
      (available at http://dx.doi.org/10.21037/atm-20-4894). The series "Rheumatologic 
      Skin Disease" was commissioned by the editorial office without any funding or 
      sponsorship. The author has no other conflicts of interest to declare.
EDAT- 2021/04/13 06:00
MHDA- 2021/04/13 06:01
PMCR- 2021/03/01
CRDT- 2021/04/12 06:25
PHST- 2021/04/12 06:25 [entrez]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/04/13 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - atm-09-05-441 [pii]
AID - 10.21037/atm-20-4894 [doi]
PST - ppublish
SO  - Ann Transl Med. 2021 Mar;9(5):441. doi: 10.21037/atm-20-4894.