PMID- 33842915
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210413
IS  - 2667-2421 (Electronic)
IS  - 2667-2421 (Linking)
VI  - 10
DP  - 2021 Jun
TI  - Genistein enhances expression of extracellular regulated kinases (ERK) 1/2, and 
      learning and memory of mouse.
PG  - 90-95
LID - 10.1016/j.ibneur.2021.01.005 [doi]
AB  - Genistein (GEN) is a well known phytoestrogen. It acts through estrogen receptor 
      (ER) and performs plethora of functions in the brain. ERK1/2 is an activated 
      kinase which involves in neuron differentiation, adult neurogenesis and several 
      brain functions including learning and memory. However, GEN dependent expression 
      of ERK1/2 and its effect in learning and memory of mice are unknown. In this 
      study, Swiss albino male mice of 25weeks weighing 30 g were used for the 
      experiments. Mice were placed in two groups- control (C) and genistein treated 
      (GEN). Treated group received GEN dissolved in sesame oil (1 mg/kg/day) whereas 
      the control group received sesame oil only. To study the effects of GEN on 
      learning and memory, open-field (OF) test and novel object recognition (NOR) test 
      were performed. Moreover, immunoblotting (IB) was performed to check the 
      expression of ERK1/2 in the mouse brain of both groups. In the OF test, no 
      significant change was observed in motor activity and anxiety in GEN treated mice 
      as compared to control. Moreover, NOR test suggested that entry towards the 
      dissimilar object was higher in case of GEN treated mice as compared to control. 
      These findings suggest higher learning and memory of GEN treated mice than of 
      control. IB showed that the expression of ERK1/2 was significantly high in GEN 
      treated mouse brain as compared to control. Such study may be helpful to 
      understand GEN mediated learning and memory involving ERK1/2.
CI  - (c) 2021 Published by Elsevier Ltd on behalf of International Brain Research 
      Organization.
FAU - Khuleshwari, Kurrey
AU  - Khuleshwari K
AD  - Cellular and Molecular Neurobiology & Drug Targeting Laboratory, Department of 
      Zoology, Indira Gandhi National Tribal University, Amarkantak, MP-484 887, India.
FAU - Vijay, Paramanik
AU  - Vijay P
AD  - Cellular and Molecular Neurobiology & Drug Targeting Laboratory, Department of 
      Zoology, Indira Gandhi National Tribal University, Amarkantak, MP-484 887, India.
LA  - eng
PT  - Journal Article
DEP - 20210129
PL  - Netherlands
TA  - IBRO Neurosci Rep
JT  - IBRO neuroscience reports
JID - 101775148
PMC - PMC8019993
OTO - NOTNLM
OT  - Brain
OT  - ERK1/2
OT  - Genistein
OT  - Immunoblotting
OT  - Learning and memory
OT  - Novel Object Recognition
OT  - Open field
EDAT- 2021/04/13 06:00
MHDA- 2021/04/13 06:01
PMCR- 2021/01/29
CRDT- 2021/04/12 06:30
PHST- 2020/09/13 00:00 [received]
PHST- 2021/01/20 00:00 [accepted]
PHST- 2021/04/12 06:30 [entrez]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/04/13 06:01 [medline]
PHST- 2021/01/29 00:00 [pmc-release]
AID - S2667-2421(21)00006-3 [pii]
AID - 10.1016/j.ibneur.2021.01.005 [doi]
PST - epublish
SO  - IBRO Neurosci Rep. 2021 Jan 29;10:90-95. doi: 10.1016/j.ibneur.2021.01.005. 
      eCollection 2021 Jun.