PMID- 33842975
OWN - NLM
STAT- MEDLINE
DCOM- 20211110
LR  - 20211110
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 60
IP  - 4
DP  - 2021 Oct 22
TI  - Surgical outcomes of infective endocarditis in children: should we delay surgery 
      for infective endocarditis?
PG  - 920-927
LID - 10.1093/ejcts/ezab149 [doi]
AB  - OBJECTIVES: We compared the surgical outcomes of infective endocarditis (IE) 
      between early surgery and non-early surgery groups in children. METHODS: From 
      January 2000 to April 2020, we retrospectively reviewed 50 patients <18years of 
      age who underwent first surgery for IE. Early surgery was defined as that 
      performed within 2 days for left-sided IE and 7 days for right-sided IE after 
      diagnosis. RESULTS: The median age and body weight at operation were 7.7 years 
      [interquartile range (IQR), 2.3-13.2] and 23.7 kg (IQR, 10.3-40.7), respectively. 
      The median follow-up duration was 9.5 years (IQR, 4.0-14.5). In 28 patients with 
      native valve endocarditis, the native valve was preserved in 23 (82.1%). The most 
      common causative microorganism was Streptococcus viridans (32.0%). The operative 
      mortality was 2.0%, and 13 (26.0%) patients required reoperation most commonly 
      for prosthesis failure (n = 7). There were no significant differences in patient 
      characteristics and perioperative data between early surgery (n = 9) and 
      non-early surgery (n = 36) groups, except for the interval between diagnosis and 
      surgery (early surgery < non-early surgery, P < 0.001) and preoperative negative 
      blood culture conversion (early surgery < non-early surgery, P = 0.025). There 
      were no significant differences in overall survival, recurrent IE, and 
      reoperation rate between the groups. Early surgery and preoperative negative 
      blood culture conversion were not found as significant factors for surgical 
      adverse outcomes. CONCLUSIONS: Surgical outcomes for IE in children were 
      acceptable irrespective of the time of surgery. Our results suggest that it may 
      not be required to delay surgery for IE and the potential benefit of early 
      surgery could be expected in children.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      European Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Lee, Jae Hong
AU  - Lee JH
AUID- ORCID: 0000-0002-9259-1391
AD  - Department of Thoracic and Cardiovascular Surgery, Seoul National University, 
      College of Medicine, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
FAU - Kwak, Jae Gun
AU  - Kwak JG
AUID- ORCID: 0000-0002-6375-1210
AD  - Department of Thoracic and Cardiovascular Surgery, Seoul National University, 
      College of Medicine, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
FAU - Cho, Sungkyu
AU  - Cho S
AUID- ORCID: 0000-0003-0492-2814
AD  - Department of Thoracic and Cardiovascular Surgery, Seoul National University, 
      College of Medicine, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
FAU - Kim, Woong-Han
AU  - Kim WH
AUID- ORCID: 0000-0003-2837-7929
AD  - Department of Thoracic and Cardiovascular Surgery, Seoul National University, 
      College of Medicine, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
FAU - Lee, Jeong Ryul
AU  - Lee JR
AD  - Department of Thoracic and Cardiovascular Surgery, Seoul National University, 
      College of Medicine, Seoul National University Children's Hospital, Seoul, 
      Republic of Korea.
FAU - Kwon, Hye Won
AU  - Kwon HW
AUID- ORCID: 0000-0002-4949-9688
AD  - Department of Pediatrics, Seoul National University, College of Medicine, Seoul 
      National University Children's Hospital, Seoul, Republic of Korea.
FAU - Song, Mi Kyoung
AU  - Song MK
AD  - Department of Pediatrics, Seoul National University, College of Medicine, Seoul 
      National University Children's Hospital, Seoul, Republic of Korea.
FAU - Lee, Sang-Yun
AU  - Lee SY
AUID- ORCID: 0000-0002-3071-2661
AD  - Department of Pediatrics, Seoul National University, College of Medicine, Seoul 
      National University Children's Hospital, Seoul, Republic of Korea.
FAU - Kim, Gi Beom
AU  - Kim GB
AUID- ORCID: 0000-0002-7880-280X
AD  - Department of Pediatrics, Seoul National University, College of Medicine, Seoul 
      National University Children's Hospital, Seoul, Republic of Korea.
FAU - Bae, Eun Jung
AU  - Bae EJ
AUID- ORCID: 0000-0003-2134-151X
AD  - Department of Pediatrics, Seoul National University, College of Medicine, Seoul 
      National University Children's Hospital, Seoul, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European 
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
CIN - Eur J Cardiothorac Surg. 2021 May 21;:. PMID: 34021305
MH  - Child
MH  - *Endocarditis/surgery
MH  - *Endocarditis, Bacterial/surgery
MH  - *Heart Valve Prosthesis
MH  - Humans
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Children
OT  - Early surgery
OT  - Infective endocarditis
EDAT- 2021/04/13 06:00
MHDA- 2021/11/11 06:00
CRDT- 2021/04/12 06:32
PHST- 2020/10/01 00:00 [received]
PHST- 2021/02/18 00:00 [revised]
PHST- 2021/02/25 00:00 [accepted]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/11/11 06:00 [medline]
PHST- 2021/04/12 06:32 [entrez]
AID - 6220442 [pii]
AID - 10.1093/ejcts/ezab149 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2021 Oct 22;60(4):920-927. doi: 10.1093/ejcts/ezab149.