PMID- 33845081
OWN - NLM
STAT- MEDLINE
DCOM- 20210707
LR  - 20210707
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 335
DP  - 2021 Jul 15
TI  - His-purkinje system pacing upgrade improve the heart performances in patients 
      suffering from pacing-induced cardiomyopathy with or without permanent atrial 
      fibrillation.
PG  - 47-51
LID - S0167-5273(21)00648-3 [pii]
LID - 10.1016/j.ijcard.2021.04.012 [doi]
AB  - INTRODUCTION: The efficacy and safety of his-purkinje system pacing (HPSP) 
      upgrades in patients with pacing-induced cardiomyopathy (PICM) and atrial 
      fibrillation (AF) are still unknown. METHODS AND RESULTS: Patients with PICM were 
      continuously enrolled from January 2018 to March 2020. All patients were further 
      divided into AF subgroup and sinus rhythm subgroup. Clinical data including 
      echocardiographic examination parameters, electrocardiogram (ECG) measurements, 
      and New York Heart Association (NYHA) classification, were assessed before and 
      after the procedure. The HPSP upgrades, including his bundle pacing (HBP) and 
      left bundle branch pacing (LBBP) were completed in 34 of 36 (94%) patients, 
      Complications including electrode dislodged, perforation, infection or thrombosis 
      were not observed in the perioperative period. During a mean of 11.52 +/- 5.40 
      months of follow-up. The left ventricular ejection fraction (LVEF) increased 
      significantly (33.76 +/- 7.54 vs 40.41 +/- 9.06, P < 0.001), and the QRS duration 
      decreased (184.22 +/- 23.76 ms vs 120.52 +/- 16.67 ms, P < 0.001) after the upgrades. 
      LVEDD reversed from 59.29 +/- 7.74 mm to 53.91 +/- 5.92 mm (P < 0.001), and the NYHA 
      functional class also improved to 2.00 +/- 0.76 from 2.55 +/- 0.91 at the first 
      follow-up (P < 0.001). The left atrium (LA) size also slightly decreased compared 
      to the initial state (47.44 +/- 7.14 mm VS 45.56 +/- 7.78, P = 0.010). BNP 
      significantly decreased from a median value of 458.06(256.35-755.10) to 
      172.31(92.69-552.14) (P = 0.004). The threshold did not increase significantly 
      (1.18 +/- 0.76 mv@0.4 ms vs 1.26 +/- 0.91mv @ 0.4 ms, P = 0.581). These improvements 
      in patients with AF were similar with those in patients without AF (P > 0.05). 
      CONCLUSIONS: HPSP upgrades improved the heart performance and reversed the left 
      ventricular remodeling in patients suffering from PICM with or without AF, and it 
      should be a promising choice in these patients.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Yang, Yi-Heng
AU  - Yang YH
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Wang, Ke-Xin
AU  - Wang KX
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Ma, Pei-Pei
AU  - Ma PP
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Zhang, Rong-Feng
AU  - Zhang RF
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Waleed, Khalid Bin
AU  - Waleed KB
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China; Department of cardiology, Fuwai Hospital Chinese Academy of 
      Medical Sciences Shenzhen, Shenzhen, Guangdong, China.
FAU - Yin, Xiaomeng
AU  - Yin X
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Gao, Lian-Jun
AU  - Gao LJ
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China.
FAU - Xia, Yun-Long
AU  - Xia YL
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China. Electronic address: yunlong_xia@126.com.
FAU - Dong, Ying-Xue
AU  - Dong YX
AD  - Department of Cardiology, First Affiliated Hospital of Dalian Medical University, 
      Dalian, China. Electronic address: dlsusan@126.com.
LA  - eng
PT  - Journal Article
DEP - 20210415
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - *Atrial Fibrillation/diagnosis/therapy
MH  - Bundle of His
MH  - Cardiac Pacing, Artificial
MH  - *Cardiomyopathies
MH  - Humans
MH  - Stroke Volume
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac function
OT  - His-Purkinje system pacing
OT  - Pacing-induced cardiomyopathy
EDAT- 2021/04/13 06:00
MHDA- 2021/07/08 06:00
CRDT- 2021/04/12 20:12
PHST- 2021/01/21 00:00 [received]
PHST- 2021/04/01 00:00 [revised]
PHST- 2021/04/06 00:00 [accepted]
PHST- 2021/04/13 06:00 [pubmed]
PHST- 2021/07/08 06:00 [medline]
PHST- 2021/04/12 20:12 [entrez]
AID - S0167-5273(21)00648-3 [pii]
AID - 10.1016/j.ijcard.2021.04.012 [doi]
PST - ppublish
SO  - Int J Cardiol. 2021 Jul 15;335:47-51. doi: 10.1016/j.ijcard.2021.04.012. Epub 
      2021 Apr 15.