PMID- 33845846
OWN - NLM
STAT- MEDLINE
DCOM- 20211111
LR  - 20211111
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 20
IP  - 1
DP  - 2021 Apr 12
TI  - Gender differences in risk factors for high plasma homocysteine levels based on a 
      retrospective checkup cohort using a generalized estimating equation analysis.
PG  - 31
LID - 10.1186/s12944-021-01459-z [doi]
LID - 31
AB  - BACKGROUND: Hyperhomocysteinemia (HHcy) is associated with various health 
      problems, but less is known about the gender differences in risk factors for high 
      plasma homocysteine (Hcy) levels. METHODS: In this study, a retrospective study 
      was carried out on 14,911 participants (7838 males and 7073 females) aged 
      16-102 years who underwent routine checkups between January 2012 and December 
      2017 in the Health Management Department of Xuanwu Hospital, China. 
      Anthropometric measurements, including body mass index (BMI) and waist-to-hip 
      ratio, were collected. Fasting blood samples were collected to measure the 
      biochemical indexes. The outcome variable was Hcy level, and a generalized 
      estimating equation (GEE) analysis was used to identify the associations of 
      interest based on gender. RESULTS: Males exhibited increased Hcy levels 
      (16.37 +/- 9.66 vs 11.22 +/- 4.76 mumol/L) and prevalence of HHcy (37.0% vs 11.3%) 
      compared with females. Hcy levels and HHcy prevalence increased with age in both 
      genders, except for the 16- to 29-year-old group. GEE analysis indicated that 
      irrespective of gender, aspartate aminotransferase, creatinine, uric acid, 
      low-density lipoprotein cholesterol and high-density lipoprotein cholesterol 
      levels were positively correlated with Hcy levels, and alanine aminotransferase, 
      total cholesterol and glucose were negatively correlated with Hcy levels. 
      However, age, BMI and triglycerides (TGs) were positively correlated with Hcy 
      levels exclusively in females. CONCLUSIONS: Gender differences in risk factors 
      for high plasma Hcy levels were noted. Although common correlational factors 
      existed in both genders, age, BMI and TGs were independent risk factors for Hcy 
      levels specifically in females.
FAU - Zhao, Jing
AU  - Zhao J
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing, 100053, China.
FAU - Li, Zhihua
AU  - Li Z
AD  - Information Center, Xuanwu Hospital, Capital Medical University, Beijing, China.
FAU - Hou, Chengbei
AU  - Hou C
AD  - Department of Evidence-based Medicine, Xuanwu Hospital, Capital Medical 
      University, Beijing, China.
FAU - Sun, Fei
AU  - Sun F
AD  - Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, 
      No. 45 Changchun Street, Xicheng District, Beijing, 100053, China.
FAU - Dong, Jing
AU  - Dong J
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing, 100053, China.
FAU - Chu, Xi
AU  - Chu X
AD  - Health Management Department, Xuanwu Hospital, Capital Medical University, No. 45 
      Changchun Street, Xicheng District, Beijing, 100053, China. cissy9007@163.com.
FAU - Guo, Yansu
AU  - Guo Y
AUID- ORCID: 0000-0002-4367-5353
AD  - Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, 
      No. 45 Changchun Street, Xicheng District, Beijing, 100053, China. 
      gys188@163.com.
LA  - eng
GR  - 81971200/National Natural Science Foundation of China/
PT  - Journal Article
DEP - 20210412
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Aged, 80 and over
MH  - China/epidemiology
MH  - Factor Analysis, Statistical
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Models, Biological
MH  - Prevalence
MH  - Retrospective Studies
MH  - Risk Factors
MH  - *Sex Characteristics
MH  - Young Adult
PMC - PMC8042914
OTO - NOTNLM
OT  - Aging
OT  - Body mass index
OT  - Gender difference
OT  - Homocysteine
OT  - Hyperhomocysteinemia
OT  - Risk factor
OT  - Triglycerides
COIS- The authors declare that they have no competing interests.
EDAT- 2021/04/14 06:00
MHDA- 2021/11/12 06:00
PMCR- 2021/04/12
CRDT- 2021/04/13 05:35
PHST- 2021/02/14 00:00 [received]
PHST- 2021/03/30 00:00 [accepted]
PHST- 2021/04/13 05:35 [entrez]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/11/12 06:00 [medline]
PHST- 2021/04/12 00:00 [pmc-release]
AID - 10.1186/s12944-021-01459-z [pii]
AID - 1459 [pii]
AID - 10.1186/s12944-021-01459-z [doi]
PST - epublish
SO  - Lipids Health Dis. 2021 Apr 12;20(1):31. doi: 10.1186/s12944-021-01459-z.