PMID- 33846922
OWN - NLM
STAT- MEDLINE
DCOM- 20210813
LR  - 20210813
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 28
IP  - 32
DP  - 2021 Aug
TI  - Dissipation behavior, residue distribution, and dietary risk assessment of 
      fluopimomide and dimethomorph in taro using HPLC-MS/MS.
PG  - 43956-43969
LID - 10.1007/s11356-021-13713-z [doi]
AB  - Dimethomorph is a morpholine broad-spectrum fungicide and effectively controls 
      taro blight, cucumber downy mildew, rice blast disease, and others. Fluopimomide 
      is a newly developed broad-spectrum fungicide to primarily control oomycetes and 
      rhizoctonia diseases. Taro, one of the earliest cultivated crops, is a staple 
      food in Africa, Oceania, and Asia. Recently, a commercial suspension concentrate 
      formulation containing 15% fluopimomide and 25% dimethomorph has been registered 
      in China, the second largest taro producer in the world. The objective of this 
      study was to develop a high-performance liquid chromatography tandem mass 
      spectrometry method to detect the residues of fluopimomide and dimethomorph 
      concurrently in taro samples. The results showed that the average recoveries of 
      fluopimomide and dimethomorph ranged from 83 to 108%, and relative standard 
      deviations (RSD) ranged from 1 to 11%. The limit of quantitation (LOQ) was 0.01 
      mg kg(-1) for the two compounds. The dissipation results demonstrated that both 
      fluopimomide and dimethomorph in taro degraded rapidly in taro fields, and the 
      residues of the two fungicides were below the LOQ within 14 days 
      post-application. The final residue levels of fluopimomide and dimethomorph in 
      taro were lower than 0.066 mg kg(-1) 28 days post-application. For dietary risk 
      assessments, the dietary structure of different genders and age of people in 
      China exposure risk assessment and whole diet exposure risk assessment shows that 
      the risk quotient (RQ) values were substantially lower than 100%, suggesting that 
      the long-term risks of fluopimomide/dimethomorph mixed formulation in taro at the 
      recommended dosage were negligible. In summary, our combined results from the 
      dissipation behaviors, terminal residues, and dietary risk assessments provide 
      the critical empirical data for the establishment of the maximum residue levels 
      (MRLs) of the two broad-spectrum fungicides in taro, a traditional food for 
      African, Oceanic, and South Asian cultures.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Yang, Lihua
AU  - Yang L
AUID- ORCID: 0000-0002-5900-6373
AD  - College of Resources and Environment, Hunan Agricultural University, Changsha, 
      410128, China.
FAU - Zhou, Xuguo
AU  - Zhou X
AD  - Department of Entomology, University of Kentucky, Lexington, KY, 40546, USA.
FAU - Deng, Yaocheng
AU  - Deng Y
AD  - College of Resources and Environment, Hunan Agricultural University, Changsha, 
      410128, China.
FAU - Gong, Daoxin
AU  - Gong D
AD  - College of Resources and Environment, Hunan Agricultural University, Changsha, 
      410128, China. gdx4910@163.com.
FAU - Luo, Haifeng
AU  - Luo H
AD  - College of Mechanical and Electrical Engineering, Hunan Agricultural University, 
      Changsha, 410128, China. luohaifeng@hunau.edu.cn.
FAU - Zhu, Ping
AU  - Zhu P
AD  - College of Resources and Environment, Hunan Agricultural University, Changsha, 
      410128, China.
LA  - eng
GR  - 19C0919/the Scientific Research Project of Hunan Provincial Department of 
      Education China/
GR  - 2018041/the Agricultural Pesticide Residue Project of the Ministry of Agriculture 
      China/
PT  - Journal Article
DEP - 20210412
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Fungicides, Industrial)
RN  - 0 (Morpholines)
RN  - 0 (Pesticide Residues)
RN  - 3EXL2158GV (dimethomorph)
SB  - IM
MH  - China
MH  - Chromatography, High Pressure Liquid
MH  - *Colocasia
MH  - Diet
MH  - Female
MH  - *Fungicides, Industrial/analysis
MH  - Half-Life
MH  - Humans
MH  - Male
MH  - Morpholines/analysis
MH  - *Pesticide Residues/analysis
MH  - Risk Assessment
MH  - Tandem Mass Spectrometry
OTO - NOTNLM
OT  - Dietary risk assessment
OT  - Dimethomorph
OT  - Fluopimomide
OT  - HPLC-MS/MS
OT  - Residue
OT  - Taro
EDAT- 2021/04/14 06:00
MHDA- 2021/08/14 06:00
CRDT- 2021/04/13 06:38
PHST- 2020/12/14 00:00 [received]
PHST- 2021/03/25 00:00 [accepted]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/08/14 06:00 [medline]
PHST- 2021/04/13 06:38 [entrez]
AID - 10.1007/s11356-021-13713-z [pii]
AID - 10.1007/s11356-021-13713-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2021 Aug;28(32):43956-43969. doi: 
      10.1007/s11356-021-13713-z. Epub 2021 Apr 12.