PMID- 33847516
OWN - NLM
STAT- MEDLINE
DCOM- 20210805
LR  - 20220922
IS  - 1527-1315 (Electronic)
IS  - 0033-8419 (Print)
IS  - 0033-8419 (Linking)
VI  - 299
IP  - 3
DP  - 2021 Jun
TI  - Quantitative Three-dimensional Assessment of Knee Joint Space Width from 
      Weight-bearing CT.
PG  - 649-659
LID - 10.1148/radiol.2021203928 [doi]
AB  - Background Imaging of structural disease in osteoarthritis has traditionally 
      relied on MRI and radiography. Joint space mapping (JSM) can be used to 
      quantitatively map joint space width (JSW) in three dimensions from CT images. 
      Purpose To demonstrate the reproducibility, repeatability, and feasibility of JSM 
      of the knee using weight-bearing CT images. Materials and Methods Two convenience 
      samples of weight-bearing CT images of left and right knees with radiographic 
      Kellgren-Lawrence grades (KLGs) less than or equal to 2 were acquired from 2014 
      to 2018 and were analyzed retrospectively with JSM to deliver three-dimensional 
      JSW maps. For reproducibility, images of three sets of knees were used for novice 
      training, and then the JSM output was compared against an expert's assessment. 
      JSM was also performed on 2-week follow-up images in the second cohort, yielding 
      three-dimensional JSW difference maps for repeatability. Statistical parametric 
      mapping was performed on all knee imaging data (KLG, 0-4) to show the feasibility 
      of a surface-based analysis in three dimensions. Results Reproducibility (in 20 
      individuals; mean age, 58 years +/- 7 [standard deviation]; mean body mass index, 
      28 kg/m(2) +/- 6; 14 women) and repeatability (in nine individuals; mean age, 53 
      years +/- 6; mean body mass index, 26 kg/m(2) +/- 4; seven women) reached their 
      lowest performance at a smallest detectable difference less than +/-0.1 mm in the 
      central medial tibiofemoral joint space for individuals without radiographically 
      demonstrated disease. The average root mean square coefficient of variation was 
      less than 5% across all groups. Statistical parametric mapping (33 individuals; 
      mean age, 57 years +/- 7; mean body mass index, 27 kg/m(2) +/- 6; 23 women) showed 
      that the central-to-posterior medial joint space was significantly narrower by 
      0.5 mm for each incremental increase in the KLG (threshold P < .05). One knee 
      (KLG, 2) demonstrated a baseline versus 24-month change in its three-dimensional 
      JSW distribution that was beyond the smallest detectable difference across the 
      lateral joint space. Conclusion Joint space mapping of the knee using 
      weight-bearing CT images is feasible, demonstrating a relationship between the 
      three-dimensional joint space width distribution and structural joint disease. It 
      is reliably learned by novice users, can be personalized for disease phenotypes, 
      and can be used to achieve a smallest detectable difference that is at least 50% 
      smaller than that reported to be achieved at the highest performance level in 
      radiography. (c) RSNA, 2021 Online supplemental material is available for this 
      article. See also the editorial by Roemer in this issue.
FAU - Turmezei, Tom D
AU  - Turmezei TD
AUID- ORCID: 0000-0003-0365-8054
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - B Low, Samantha
AU  - B Low S
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Rupret, Simon
AU  - Rupret S
AUID- ORCID: 0000-0003-4643-5555
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Treece, Graham M
AU  - Treece GM
AUID- ORCID: 0000-0003-0047-6845
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Gee, Andrew H
AU  - Gee AH
AUID- ORCID: 0000-0001-8467-3023
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - MacKay, James W
AU  - MacKay JW
AUID- ORCID: 0000-0001-7558-3800
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Lynch, John A
AU  - Lynch JA
AUID- ORCID: 0000-0003-3624-2741
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Poole, Kenneth E S
AU  - Poole KES
AUID- ORCID: 0000-0003-4546-7352
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
FAU - Segal, Neil A
AU  - Segal NA
AUID- ORCID: 0000-0002-8294-080X
AD  - From the Department of Radiology, Norfolk and Norwich University Hospitals NHS 
      Foundation Trust, Colney Lane, Norwich NR4 7UY, England (T.D.T., J.W.M.); Norwich 
      Medical School, University of East Anglia, Norwich, England (T.D.T., J.W.M.); 
      Royal Liverpool University Hospital, Liverpool, England (S.B.L.); Department of 
      Radiology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, 
      England (S.R.); Departments of Engineering (G.M.T., A.H.G.) and Medicine 
      (K.E.S.P.), University of Cambridge, Cambridge, England; Department of 
      Epidemiology and Biostatistics, University of California-San Francisco, San 
      Francisco, Calif (J.A.L.); and Department of Physical Medicine and 
      Rehabilitation, Kansas University Medical Center, Kansas City, Kan (N.A.S.).
LA  - eng
GR  - 20109/VAC_/Versus Arthritis/United Kingdom
GR  - R01 AR071648/AR/NIAMS NIH HHS/United States
GR  - U01 AG018832/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20210413
PL  - United States
TA  - Radiology
JT  - Radiology
JID - 0401260
SB  - IM
CIN - Radiology. 2021 Apr 13;:210357. PMID: 33851885
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Imaging, Three-Dimensional/*methods
MH  - Male
MH  - Middle Aged
MH  - Osteoarthritis, Knee/*diagnostic imaging
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Tomography, X-Ray Computed/*methods
MH  - *Weight-Bearing
PMC - PMC9490554
MID - NIHMS1831148
EDAT- 2021/04/14 06:00
MHDA- 2021/08/06 06:00
PMCR- 2022/09/21
CRDT- 2021/04/13 12:09
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/08/06 06:00 [medline]
PHST- 2021/04/13 12:09 [entrez]
PHST- 2022/09/21 00:00 [pmc-release]
AID - 10.1148/radiol.2021203928 [doi]
PST - ppublish
SO  - Radiology. 2021 Jun;299(3):649-659. doi: 10.1148/radiol.2021203928. Epub 2021 Apr 
      13.