PMID- 33847643
OWN - NLM
STAT- MEDLINE
DCOM- 20210428
LR  - 20230103
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 100
IP  - 15
DP  - 2021 Apr 16
TI  - Correlation analysis of IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 2 diabetes 
      mellitus complicated with hypothyroidism.
PG  - e25432
LID - 10.1097/MD.0000000000025432 [doi]
LID - e25432
AB  - To analyze the correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and type 
      2 diabetes mellitus (T2DM) complicated with hypothyroidism.Fifty-five patients 
      with type-2 diabetes who were admitted to our hospital from August 2018 to 
      February 2020 were selected as the control group, and 55 patients with type 2 
      diabetes combined with hypothyroidism who were admitted to the hospital at the 
      same period were selected as the combined group, and 56 patients who came to our 
      hospital for physical examination at the same period were selected as the healthy 
      group. The general clinical data and relevant laboratory indexes of all patients 
      in the three groups were collected and statistically analyzed. Besides, the 
      correlation between IGF-1, ZAG, nesfatin-1, HbA1c levels, and T2DM complicated 
      with hypothyroidism was analyzed.Levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, 
      TgAb, and HOMA-IR in the diabetes group and combined group were all significantly 
      higher than those in the healthy group, while HDL and T4 levels in the diabetes 
      group and combined group were lower than those in the healthy group (P < .05). 
      The levels of FPG, FINS, TC, TG, LDL, 2hPBG, TPOAb, and TgAb in the combined 
      group were significantly higher than those in the diabetes group (P < .05), and 
      the levels of HDL and T4 were lower than those in the diabetes group. In 
      addition, the IGF-1 level was positively correlated with ZAG, nesfatin-1, and 
      HbA1c levels in the combined group (P < .05), and IGF-1 (OR: 0.964, 95% CI: 
      0.943-0.983, P = .001), ZAG (OR: 1.298, 95% CI: 1.121-1.401, P = .005), 
      nesfatin-1 (OR: 0.876, 95% CI: 0.751-0.901, P = .002), and HbA1c (OR: 1.321, 95% 
      CI: 1.121-1.401, P = .012) were independent risk factors for T2DM complicated 
      with hypothyroidism.Regular detection of IGF-1, ZAG, nesfatin-1, and HbA1c levels 
      are of great value for the diagnosis and treatment of patients with T2DM 
      complicated with hypothyroidism.
CI  - Copyright (c) 2021 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - He, Shuangling
AU  - He S
AUID- ORCID: 0000-0002-7876-9683
AD  - Department of Endocrinology, Affiliated Hospital of Jilin Medical University, 
      Jilin, China.
FAU - He, Ying
AU  - He Y
FAU - Jin, Fenghua
AU  - Jin F
FAU - Liu, Yanjie
AU  - Liu Y
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (NUCB2 protein, human)
RN  - 0 (Nucleobindins)
RN  - 0 (Seminal Plasma Proteins)
RN  - 0 (Zn-Alpha-2-Glycoprotein)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Blood Glucose
MH  - Body Mass Index
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Health Behavior
MH  - Humans
MH  - Hypothyroidism/*epidemiology
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Male
MH  - Middle Aged
MH  - Nucleobindins/*blood
MH  - Risk Factors
MH  - Seminal Plasma Proteins/*blood
MH  - Sex Factors
MH  - Zn-Alpha-2-Glycoprotein
PMC - PMC8052084
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2021/04/14 06:00
MHDA- 2021/04/29 06:00
PMCR- 2021/04/16
CRDT- 2021/04/13 12:12
PHST- 2020/10/18 00:00 [received]
PHST- 2021/03/13 00:00 [accepted]
PHST- 2021/04/13 12:12 [entrez]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/04/29 06:00 [medline]
PHST- 2021/04/16 00:00 [pmc-release]
AID - 00005792-202104160-00039 [pii]
AID - MD-D-20-10158 [pii]
AID - 10.1097/MD.0000000000025432 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2021 Apr 16;100(15):e25432. doi: 
      10.1097/MD.0000000000025432.