PMID- 33848259
OWN - NLM
STAT- MEDLINE
DCOM- 20211215
LR  - 20211215
IS  - 2332-7812 (Electronic)
IS  - 2332-7812 (Linking)
VI  - 8
IP  - 3
DP  - 2021 May
TI  - Clinical and Prognostic Value of Immunogenetic Characteristics in Anti-LGI1 
      Encephalitis.
LID - 10.1212/NXI.0000000000000974 [doi]
LID - e974
AB  - OBJECTIVE: Antibodies against leucine-rich glioma-inactivated 1 (LGI1-Abs) 
      characterize a limbic encephalitis (LE) strongly associated with HLA-DRB1*07:01, 
      although some patients lack LGI1-Abs in CSF or do not carry this allele. Whether 
      they represent a different subtype of disease or have different prognoses is 
      unclear. METHODS: Retrospective analysis of clinical features, IgG isotypes, and 
      outcome according to LGI1-Ab CSF positivity and DRB1*07:01 in a cohort of 
      anti-LGI1 LE patients. RESULTS: Patients with LGI1-Abs detected in both CSF and 
      serum (105/134, 78%) were compared with those who were CSF negative (29/134, 
      22%). Both groups had similar clinical features and serum levels, but 
      CSF-positive patients had shorter diagnostic delay, more frequently hyponatremia, 
      inflammatory CSF, and abnormal MRI (p < 0.05). Human leukocyte antigen (HLA) 
      genotyping was performed in 72/134 (54%) patients and 63/72 (88%) carried 
      DRB1*07:01. Noncarriers (9/72, 12%) were younger, more commonly women, and had 
      less frequently psychiatric and frontal symptoms (p < 0.05). No difference in IgG 
      isotypes according to CSF positivity or HLA was found (p > 0.05). HLA and IgG 
      isotypes were not associated with poor outcome (mRS >2 at last follow-up) in 
      univariate analyses; CSF positivity was only identified as a poor outcome 
      predictor in the multivariate analysis including the complete follow-up, whereas 
      age and female sex also remained when just the first year was considered. 
      CONCLUSIONS: LE without CSF LGI1-Abs is clinically indistinguishable and likely 
      reflects just a lesser LGI1-Ab production. HLA association is sex and age biased 
      and presents clinical particularities, suggesting subtle differences in the 
      immune response. Long-term outcome depends mostly on demographic characteristics 
      and the intensity of the intrathecal synthesis.
CI  - Copyright (c) 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the American Academy of Neurology.
FAU - Muniz-Castrillo, Sergio
AU  - Muniz-Castrillo S
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Haesebaert, Julie
AU  - Haesebaert J
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Thomas, Laure
AU  - Thomas L
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Vogrig, Alberto
AU  - Vogrig A
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Pinto, Anne-Laurie
AU  - Pinto AL
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Picard, Geraldine
AU  - Picard G
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Blanc, Charlotte
AU  - Blanc C
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Do, Le-Duy
AU  - Do LD
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Joubert, Bastien
AU  - Joubert B
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Berzero, Giulia
AU  - Berzero G
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Psimaras, Dimitri
AU  - Psimaras D
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Alentorn, Agusti
AU  - Alentorn A
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Rogemond, Veronique
AU  - Rogemond V
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Dubois, Valerie
AU  - Dubois V
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Ambati, Aditya
AU  - Ambati A
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Tamouza, Ryad
AU  - Tamouza R
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Mignot, Emmanuel
AU  - Mignot E
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France.
FAU - Honnorat, Jerome
AU  - Honnorat J
AD  - From the French Reference Center on Paraneoplastic Neurological Syndromes and 
      Autoimmune Encephalitis (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., 
      V.R., J. Honnorat), Hospices Civils de Lyon, Hopital Neurologique, Bron, France; 
      SynatAc Team (S.M.-C., L.T., A.V., A.-L.P., G.P., C.B., L.-D.D., B.J., V.R., J. 
      Honnorat), Institut NeuroMyoGene, INSERM U1217/CNRS UMR 5310, Universite de Lyon, 
      Universite Claude Bernard Lyon 1, France; Clinic Research and Epidemiology 
      Department (J. Haesebaert), Hospices Civils de Lyon, Lyon, France, HESPER Team, 
      EA 7425, Medicine School, Universite Claude Bernard Lyon 1, France; Neurology 
      Department 2-Mazarin (G.B., D.P., A. Alentorn), Hopitaux Universitaires La Pitie 
      Salpetriere-Charles Foix, APHP; Brain and Spinal Cord Institute (G.B., D.P., A. 
      Alentorn), INSERM U1127/CNRS UMR 7255, Universite Pierre-et-Marie-Curie, 
      Universites Sorbonnes, Paris, France; HLA Laboratory (V.D.), French Blood 
      Service, EFS Auvergne-Rhone-Alpes, Lyon, France; Stanford University Center for 
      Sleep Sciences and Medicine (A. Ambati, E.M.), Palo Alto, CA; and Department of 
      Psychiatry (R.T.), Hopitaux Universitaires Henri Mondor, Creteil, France, Mondor 
      Institute for Biomedical Research, INSERM U955, Universite de Paris-Est-Creteil, 
      France. jerome.honnorat@chu-lyon.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210305
PL  - United States
TA  - Neurol Neuroimmunol Neuroinflamm
JT  - Neurology(R) neuroimmunology & neuroinflammation
JID - 101636388
RN  - 0 (Autoantibodies)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (LGI1 protein, human)
RN  - 0 (anti-leucine-rich glioma-inactivated 1 autoantibody)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Animals
MH  - Autoantibodies/blood/cerebrospinal fluid
MH  - Cohort Studies
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Immunogenetics
MH  - Immunoglobulin G/blood/cerebrospinal fluid
MH  - Intracellular Signaling Peptides and Proteins
MH  - Limbic Encephalitis/*genetics/*immunology/therapy
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Rats
MH  - Retrospective Studies
PMC - PMC7938443
EDAT- 2021/04/14 06:00
MHDA- 2021/12/16 06:00
PMCR- 2021/03/05
CRDT- 2021/04/13 17:12
PHST- 2020/09/08 00:00 [received]
PHST- 2021/01/04 00:00 [accepted]
PHST- 2021/04/13 17:12 [entrez]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/12/16 06:00 [medline]
PHST- 2021/03/05 00:00 [pmc-release]
AID - 8/3/e974 [pii]
AID - NEURIMMINFL2020035568 [pii]
AID - 10.1212/NXI.0000000000000974 [doi]
PST - epublish
SO  - Neurol Neuroimmunol Neuroinflamm. 2021 Mar 5;8(3):e974. doi: 
      10.1212/NXI.0000000000000974. Print 2021 May.