PMID- 33848668
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20220207
IS  - 2210-741X (Electronic)
IS  - 2210-7401 (Linking)
VI  - 45
IP  - 3
DP  - 2021 May
TI  - Palliation of malignant esophageal obstruction using an anti-migration 
      self-expandable metal stent: Results of a prospective multicenter study.
PG  - 101683
LID - S2210-7401(21)00062-0 [pii]
LID - 10.1016/j.clinre.2021.101683 [doi]
AB  - BACKGROUND: Self-expanding metal stents (SEMS) placement is primarily indicated 
      to palliate dysphagia for patients with expected short-term survival. We aimed to 
      assess the migration rate and other stent-related adverse events (AEs) of a fully 
      covered SEMS with an anti-migration system (FCSEMS-AMS) for palliation of 
      malignant dysphagia. METHODS: This is a prospective study including patients with 
      inoperable esophageal cancer that received a FCSEMS-AMS (Taewoong, Niti-S Beta), 
      in five tertiary-care endoscopic centers from January 2014 to February 2016. 
      RESULTS: Fifty-three consecutive patients were enrolled. Tumor location was 
      proximal, mid and distal esophagus+/-esophago-gastric junction (EGJ) in 6, 14, and 
      33 cases, respectively. Overall, non-severe AEs were reported in 18 patients 
      (34.0%), 13 of them required an additional endoscopic procedure. Migration 
      occurred in 7 patients (13.2%): 3 from the upper and 4 from the lower esophagus 
      and EGJ. Stent retrieval was necessary in one patient due to intolerable pain. 
      Food bolus impaction and tumor overgrowth occurred in 2 patients (3.8%) and 4 
      (7.5%) patients respectively. Four patients complained of gastroesophageal reflux 
      as late AEs. Median follow-up was 19.3 months. Dysphagia significantly improved 
      until 3 and 6 months from stent insertion (median score before FCSEMS-AMS: 3, vs 
      median score: 1). Median dysphagia-free time was 10 months. CONCLUSIONS: 
      Placement of the Taewoong, Niti-S Beta stent appeared to be a safe and effective 
      treatment of malignant dysphagia. The anti-migration system reduced the overall 
      migration rate, although it remained high in strictures located in the upper 
      esophagus and when the stent was placed across the EGJ.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - Conio, Massimo
AU  - Conio M
AD  - Department of Gastroenterology, General Hospital, Sanremo (IM), Italy; Department 
      of Gastroenterology, Santa Corona General Hospital, Pietra Ligure (SV), Italy. 
      Electronic address: mxconio@tim.it.
FAU - Savarese, Maria Flavia
AU  - Savarese MF
AD  - Department of Gastroenterology, General Hospital, Sanremo (IM), Italy.
FAU - Filiberti, Rosa Angela
AU  - Filiberti RA
AD  - IRCCS Ospedale Policlinico San Martino, Clinical Epidemiology, Genova, Italy.
FAU - Baron, Todd Huntley
AU  - Baron TH
AD  - Division of Gastroenterology and Hepatology, University of North Carolina, Chapel 
      Hill, NC, USA.
FAU - Caruso, Angelo
AU  - Caruso A
AD  - Gastroenterology and Digestive Endoscopy Department, Azienda Ospedaliera 
      Universitaria di Modena, Sant'Agostino Estense Hospital, Baggiovara (MO), Italy.
FAU - Manta, Raffaele
AU  - Manta R
AD  - Gastroenterology and Digestive Endoscopy, General Hospital, 06129 Perugia, Italy.
FAU - Marini, Mario
AU  - Marini M
AD  - Gastroenterology and Operative Endoscopy Unit, Santa Maria Alle Scotte Hospital, 
      Siena, Italy.
FAU - De Luca, Luca
AU  - De Luca L
AD  - Gastroenterology and Digestive Endoscopy Unit, Ospedali Riuniti Marche Nord, 
      Pesaro, Italy.
FAU - De Ceglie, Antonella
AU  - De Ceglie A
AD  - Department of Gastroenterology, General Hospital, Sanremo (IM), Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20210410
PL  - France
TA  - Clin Res Hepatol Gastroenterol
JT  - Clinics and research in hepatology and gastroenterology
JID - 101553659
SB  - IM
MH  - *Deglutition Disorders/etiology/therapy
MH  - *Esophageal Neoplasms/complications
MH  - *Esophageal Stenosis/etiology/surgery
MH  - Humans
MH  - Palliative Care
MH  - Prospective Studies
MH  - *Self Expandable Metallic Stents
MH  - Stents
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Malignant esophageal obstruction
OT  - Metal stent
OT  - Palliation
EDAT- 2021/04/14 06:00
MHDA- 2022/02/08 06:00
CRDT- 2021/04/13 20:14
PHST- 2020/11/01 00:00 [received]
PHST- 2021/01/23 00:00 [revised]
PHST- 2021/03/07 00:00 [accepted]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/04/13 20:14 [entrez]
AID - S2210-7401(21)00062-0 [pii]
AID - 10.1016/j.clinre.2021.101683 [doi]
PST - ppublish
SO  - Clin Res Hepatol Gastroenterol. 2021 May;45(3):101683. doi: 
      10.1016/j.clinre.2021.101683. Epub 2021 Apr 10.