PMID- 33848734
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240222
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 216
DP  - 2021 Apr 10
TI  - Immune response and susceptibility of Nile tilapia fish to Aeromonas hydrophila 
      infection following the exposure to Bifenthrin and/or supplementation with 
      Petroselinum crispum essential oil.
PG  - 112205
LID - S0147-6513(21)00316-X [pii]
LID - 10.1016/j.ecoenv.2021.112205 [doi]
AB  - Bifenthrin (BF) is a widely used 3rd generation type I pyrethroid with a 
      potential toxic effect in fish. Nevertheless, its effect on the immune system 
      remains unclear. In the present study, Oreochromis niloticus was exposed to BF at 
      0.68 mug/L for 60 days, followed by evaluating the hematological, biochemical, and 
      immunological responses. Additionally, the potential of parsley (Petroselinum 
      crispum) essential oil (PEO) to ameliorate the BF-induced toxic insults was 
      explored. Our data have shown reductions in the growth performance with 
      alterations observed in the hematological variables, protein profile and serum 
      biomarkers of stress. DNA oxidative damage was evidenced by elevation of serum 
      8-hydroxy-2-deoxyguanosine (8-OHdG) content. BF-exposed fish presented also 
      decline in serum lysozyme activity and levels of immunoglobulins (IgG and IgM) 
      and nitric oxide (NO), with diminished resistance to Aeromonas hydrophila 
      challenge. Furthermore, the RT-PCR analysis showed an upregulated expression 
      pattern of immune -related genes including interleukin 1beta (IL-1beta), interferon - gamma 
      (IFN-gamma) and tumor necrosis factor - alpha (TNF-alpha) genes in the liver tissue. Dietary 
      co-supplementation of PEO at 1 or 2 mL/kg diet with concomitant BF exposure, 
      alleviated the adverse effects of the insecticide in a dose-dependent manner. The 
      observations from this study demonstrate the immunomodulation by BF and provide 
      further insight into the protective properties of PEO and strengthen its 
      applicability as a promising feed supplement to fish.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Farag, Mayada R
AU  - Farag MR
AD  - Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt.
FAU - Alagawany, Mahmoud
AU  - Alagawany M
AD  - Poultry Department, Agriculture Faculty, Zagazig University, Zagazig 44519, 
      Egypt.
FAU - Taha, Heba S A
AU  - Taha HSA
AD  - Genetic Department, Faculty of Agriculture, Zagazig University, Zagazig 44519, 
      Egypt.
FAU - Ismail, Tamer Ahmed
AU  - Ismail TA
AD  - Department of Clinical Laboratory Sciences, Turabah University College, Taif 
      University, P.O. Box 11099, Taif 21944, Saudi Arabia.
FAU - Khalil, Samah R
AU  - Khalil SR
AD  - Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, 
      Zagazig University, Zagazig 44519, Egypt. Electronic address: 
      dr_samahkhalil@yahoo.com.
FAU - Abou-Zeid, Shimaa M
AU  - Abou-Zeid SM
AD  - Forensic Medicine and Toxicology Department, Faculty of Veterinary Medicine, 
      University of Sadat City, 32897, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20210410
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
SB  - IM
OTO - NOTNLM
OT  - 8-hydroxy-2-deoxyguanosine
OT  - Bifenthrin
OT  - Immunity
OT  - Oreochromis niloticus
OT  - Petroselinum crispum
EDAT- 2021/04/14 06:00
MHDA- 2021/04/14 06:01
CRDT- 2021/04/13 20:17
PHST- 2021/01/26 00:00 [received]
PHST- 2021/03/23 00:00 [revised]
PHST- 2021/03/29 00:00 [accepted]
PHST- 2021/04/14 06:01 [medline]
PHST- 2021/04/14 06:00 [pubmed]
PHST- 2021/04/13 20:17 [entrez]
AID - S0147-6513(21)00316-X [pii]
AID - 10.1016/j.ecoenv.2021.112205 [doi]
PST - aheadofprint
SO  - Ecotoxicol Environ Saf. 2021 Apr 10;216:112205. doi: 
      10.1016/j.ecoenv.2021.112205.