PMID- 33849815
OWN - NLM
STAT- MEDLINE
DCOM- 20211015
LR  - 20211015
IS  - 1878-0210 (Electronic)
IS  - 1878-0210 (Linking)
VI  - 15
IP  - 4
DP  - 2021 Aug
TI  - Association between serum uric acid levels and cardiovascular events in 
      hospitalized patients with type 2 diabetes.
PG  - 682-687
LID - S1751-9918(21)00043-7 [pii]
LID - 10.1016/j.pcd.2021.03.003 [doi]
AB  - AIMS: This study aimed to determine the association between serum uric acid (UA) 
      levels and cardiovascular events in hospitalized patients with type 2 diabetes 
      mellitus (T2DM). METHODS: A retrospective cohort study was conducted in 2227 
      hospitalized patients with T2DM. Cox proportional hazards regression was used to 
      assess the association between serum UA and cardiovascular events, including 
      cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, heart 
      failure, unstable angina, and arrhythmias requiring hospitalization. RESULTS: 
      Among 1314 men, 143 (10.9%) experienced cardiovascular events. Serum UA level was 
      not associated with the risk of cardiovascular events (hazard ratio [HR] per 100 
      mumol/L increase in serum UA: 1.12, 95% confidence interval [CI]: 0.90-1.40). 
      Among 913 women, 96 (10.5%) experienced cardiovascular events. For every 100 
      mumol/L increase in serum UA level, the risk of experiencing a cardiovascular 
      event increased by 27% (HR: 1.27, 95% CI: 1.02-1.57). CONCLUSIONS: In 
      hospitalized patients with T2DM, baseline serum UA levels were positively 
      associated with cardiovascular events in women, but not in men. Serum UA levels 
      may be a significant independent risk factor for cardiovascular events in women 
      with T2DM.
CI  - Copyright (c) 2021. Published by Elsevier Ltd.
FAU - Chang, Zhan
AU  - Chang Z
AD  - Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen 
      South Street, Xicheng District, Beijing, 100044, China; Department of 
      Endocrinology, Second Hospital of Shijiazhuang, 53 Huaxi Road, Shijiazhuang, 
      Hebei, 050000, China.
FAU - Zhou, Xiang-Hai
AU  - Zhou XH
AD  - Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen 
      South Street, Xicheng District, Beijing, 100044, China. Electronic address: 
      xianghaizhou1@163.c.
FAU - Wen, Xin
AU  - Wen X
AD  - Department of Endocrinology, Peking University People's Hospital, 11 Xizhimen 
      South Street, Xicheng District, Beijing, 100044, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210410
PL  - England
TA  - Prim Care Diabetes
JT  - Primary care diabetes
JID - 101463825
RN  - 268B43MJ25 (Uric Acid)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/diagnosis/epidemiology
MH  - Female
MH  - *Heart Failure
MH  - Humans
MH  - Male
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Uric Acid
OTO - NOTNLM
OT  - Antioxidant
OT  - Cardiovascular events
OT  - Oxidant
OT  - Type 2 diabetes mellitus
OT  - Uric acid
EDAT- 2021/04/15 06:00
MHDA- 2021/10/16 06:00
CRDT- 2021/04/14 05:50
PHST- 2020/02/09 00:00 [received]
PHST- 2021/03/09 00:00 [revised]
PHST- 2021/03/14 00:00 [accepted]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2021/10/16 06:00 [medline]
PHST- 2021/04/14 05:50 [entrez]
AID - S1751-9918(21)00043-7 [pii]
AID - 10.1016/j.pcd.2021.03.003 [doi]
PST - ppublish
SO  - Prim Care Diabetes. 2021 Aug;15(4):682-687. doi: 10.1016/j.pcd.2021.03.003. Epub 
      2021 Apr 10.