PMID- 33850400
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220422
IS  - 0976-237X (Print)
IS  - 0976-2361 (Electronic)
IS  - 0976-2361 (Linking)
VI  - 11
IP  - 4
DP  - 2020 Oct-Dec
TI  - Comparative Evaluation of Serum Tumor Necrosis Factor alpha in Health and Chronic 
      Periodontitis: A Case-Control Study.
PG  - 342-349
LID - 10.4103/ccd.ccd_97_18 [doi]
AB  - BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha), a " major inflammatory 
      cytokine," not only plays an important role in periodontal destruction but also 
      is extremely toxic to the host. Till date, there are not many studies comparing 
      the levels of TNF-alpha in serum and its relationship to periodontal disease. AIM: 
      Our study aimed to compare the serum TNF-alpha among the two study groups, namely, 
      healthy controls and chronic periodontitis patients and establish a correlation 
      between serum TNF-alpha and various clinical parameters. Hence, an attempt is made to 
      estimate the level of TNF-alpha in serum, its relationship to periodontal disease and 
      to explore the possibility of using the level of TNF-alpha in serum as a biochemical 
      " marker" of periodontal disease. MATERIALS AND METHODS: Forty individuals 
      participated in the study and were grouped into two subgroups. Group A - 20 
      systemically and periodontally healthy controls. Group B - twenty patients with 
      generalized chronic periodontitis. The serum samples were assayed for TNF-alpha 
      levels by enzyme-linked immunosorbent assay method. RESULTS: The mean serum TNF-alpha 
      cytokines for Group B Generalized chronic periodontitis (GCP) was 2.977 +/- 1.011, 
      and Group A (healthy) was 0.867 +/- 0.865. The range of serum TNF-alpha was from (0.867 
      to 2.977). Serum TNF-alpha cytokines had highly significant correlation with all 
      clinical parameters (plaque index, probing pocket depth, clinical attachment 
      loss, and gingival index) among all study participants (P = 0.001). CONCLUSION: 
      These observations suggest a positive association between periodontal disease and 
      increased levels of TNF-alpha in serum. It can be concluded that there is a prospect 
      of using the estimation of TNF-alpha in serum as a "marker" of periodontal disease in 
      future. However, it remains a possibility that the absence or low levels of TNF-alpha 
      in serum might indicate a stable lesion and elevated levels might indicate an 
      active site but only longitudinal studies taking into account, the disease 
      "activity" and "inactivity" could suggest the possibility of using TNF-alpha in serum 
      as an "Indicator" of periodontal disease.
CI  - Copyright: (c) 2020 Contemporary Clinical Dentistry.
FAU - Jain, Prince
AU  - Jain P
AD  - Consultant Periodontist and Implantologist, Vidisha, India.
FAU - Ved, Aditi
AU  - Ved A
AD  - Dental Surgeon, Dental Planet Clinic, Vidisha, India.
FAU - Dubey, Rajat
AU  - Dubey R
AD  - Department of Dentistry, Government Hospital, Ratlam, India.
FAU - Singh, Neha
AU  - Singh N
AD  - Consultant Periodontist, Bhopal, India.
FAU - Parihar, Anuj Singh
AU  - Parihar AS
AD  - People's Dental Academy, Bhopal Madhya Pradesh, India.
FAU - Maytreyee, Rochira
AU  - Maytreyee R
AD  - Dental Surgeon, Apollo Hospital, New Delhi, India.
LA  - eng
PT  - Journal Article
DEP - 20201220
PL  - India
TA  - Contemp Clin Dent
JT  - Contemporary clinical dentistry
JID - 101552967
PMC - PMC8035841
OTO - NOTNLM
OT  - Generalized chronic periodontitis
OT  - Inflammation
OT  - Tumor necrosis factor alpha
COIS- There are no conflicts of interest.
EDAT- 2021/04/15 06:00
MHDA- 2021/04/15 06:01
PMCR- 2020/10/01
CRDT- 2021/04/14 06:31
PHST- 2018/02/16 00:00 [received]
PHST- 2020/04/08 00:00 [accepted]
PHST- 2021/04/14 06:31 [entrez]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2021/04/15 06:01 [medline]
PHST- 2020/10/01 00:00 [pmc-release]
AID - CCD-11-342 [pii]
AID - 10.4103/ccd.ccd_97_18 [doi]
PST - ppublish
SO  - Contemp Clin Dent. 2020 Oct-Dec;11(4):342-349. doi: 10.4103/ccd.ccd_97_18. Epub 
      2020 Dec 20.