PMID- 33850676
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210416
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 3
DP  - 2021 Mar 11
TI  - Consequences of Diabetes Mellitus in Bone Health: Traditional Review.
PG  - e13820
LID - 10.7759/cureus.13820 [doi]
LID - e13820
AB  - The diabetes mellitus (DM) pandemic was mostly related to the growing incidence 
      of osteoporosis worldwide. Thus, DM-induced bone fragility was recently reported 
      as a diabetic complication. This disorder needs to be identified and diagnosed 
      early and adequately to avoid more symptoms and impairments. Bone weight is 
      lowered and the risk of fractures rises in type 1 diabetes mellitus (T1DM). 
      However, type 2 diabetes mellitus (T2DM) will increase bone density per se 
      because of the elevated chance of fracturing. This indicates that bone 
      consistency plays an important part in the pathogenesis of diseases. This 
      research is aimed at defining the function of advanced glycation end-products 
      (AGEs), micro-architectural changes, and altered bone turnover. The risk of 
      fracture can be varied by drugs used for treating DM. Thiazolidinedione 
      exacerbates bone degradation, for example, which raises the risk of fractures, 
      particularly in older females. In contrast, metformin and sulfonylureas appeared 
      to have no adverse effects on bone health and could guard against fragility. 
      Evaluating bone mineral density (BMD) and other risk factors may aid in 
      developing tailor-made recovery plans as part of the diagnostic process. 
      Increased osteoporosis awareness is important, considering the increasing and 
      older population of DM patients.
CI  - Copyright (c) 2021, Kumari et al.
FAU - Kumari, Cheena
AU  - Kumari C
AD  - Internal Medicine, California Institute of Behavioral Neurosciences and 
      Psychology, Fairfield, USA.
FAU - Yagoub, Ghozlan
AU  - Yagoub G
AD  - Internal Medicine, California Institute of Behavioral Neurosciences and 
      Psychology, Fairfield, USA.
FAU - Ashfaque, Mariam
AU  - Ashfaque M
AD  - Internal Medicine, California Institute of Behavioral Neurosciences and 
      Psychology, Fairfield, USA.
FAU - Jawed, Sobia
AU  - Jawed S
AD  - Internal Medicine, California Institute of Behavioral Neurosciences and 
      Psychology, Fairfield, USA.
FAU - Hamid, Pousette
AU  - Hamid P
AD  - Neurology, California Institute of Behavioral Neurosciences and Psychology, 
      Fairfield, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210311
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8035852
OTO - NOTNLM
OT  - diabetes mellitus
OT  - fracture
OT  - osteoporosis
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/04/15 06:00
MHDA- 2021/04/15 06:01
PMCR- 2021/03/11
CRDT- 2021/04/14 06:34
PHST- 2021/04/14 06:34 [entrez]
PHST- 2021/04/15 06:00 [pubmed]
PHST- 2021/04/15 06:01 [medline]
PHST- 2021/03/11 00:00 [pmc-release]
AID - 10.7759/cureus.13820 [doi]
PST - epublish
SO  - Cureus. 2021 Mar 11;13(3):e13820. doi: 10.7759/cureus.13820.